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Abnormal telomere morphology

MedGen UID:
1626627
Concept ID:
C4531139
Cell or Molecular Dysfunction
HPO: HP:0031412

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal telomere morphology

Professional guidelines

PubMed

de Coo IFM, Jesse S, Le TL, Sala C; European Phelan-McDermid syndrome consortium
Eur J Med Genet 2023 Jun;66(6):104746. Epub 2023 Mar 24 doi: 10.1016/j.ejmg.2023.104746. PMID: 36967043
Pompili L, Leonetti C, Biroccio A, Salvati E
J Exp Clin Cancer Res 2017 Dec 22;36(1):189. doi: 10.1186/s13046-017-0657-3. PMID: 29273061Free PMC Article
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko JK, Daga A, Basta T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch'ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai WM, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder ER, Rump P, Schnur RE, Shiihara T, Sinha MD, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Callewaert B, van Tilbeurgh H, Zenker M, Antignac C, Hildebrandt F
Nat Genet 2017 Oct;49(10):1529-1538. Epub 2017 Aug 14 doi: 10.1038/ng.3933. PMID: 28805828Free PMC Article

Recent clinical studies

Etiology

Savage SA
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):637-648. doi: 10.1182/hematology.2022000394. PMID: 36485133Free PMC Article
Nix JS, Blakeley J, Rodriguez FJ
Acta Neuropathol 2020 Apr;139(4):625-641. Epub 2019 Apr 8 doi: 10.1007/s00401-019-02002-2. PMID: 30963251Free PMC Article
Boddu PC, Kadia TM
Eur J Haematol 2019 Feb;102(2):103-110. Epub 2018 Dec 18 doi: 10.1111/ejh.13182. PMID: 30380171
Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR, O'Brien T, Martincorena I, Tarpey P, Angelopoulos N, Yates LR, Butler AP, Raine K, Stewart GD, Challacombe B, Fernando A, Lopez JI, Hazell S, Chandra A, Chowdhury S, Rudman S, Soultati A, Stamp G, Fotiadis N, Pickering L, Au L, Spain L, Lynch J, Stares M, Teague J, Maura F, Wedge DC, Horswell S, Chambers T, Litchfield K, Xu H, Stewart A, Elaidi R, Oudard S, McGranahan N, Csabai I, Gore M, Futreal PA, Larkin J, Lynch AG, Szallasi Z, Swanton C, Campbell PJ; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):611-623.e17. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.02.020. PMID: 29656891Free PMC Article
Savage SA, Alter BP
Hematol Oncol Clin North Am 2009 Apr;23(2):215-31. doi: 10.1016/j.hoc.2009.01.003. PMID: 19327580Free PMC Article

Diagnosis

Özdek Ş, Özdemir Zeydanlı E, Baumal C, Hoyek S, Patel N, Berrocal A, Lopez-Cañizares A, Al-Khersan H, Kusaka S, Mano F, Jalali S, Lepore D, Akar S
Turk J Ophthalmol 2023 Feb 24;53(1):44-57. doi: 10.4274/tjo.galenos.2022.76436. PMID: 36847634Free PMC Article
Dong S, Chen C, Zhang J, Gao Y, Zeng X, Zhang X
Front Endocrinol (Lausanne) 2022;13:1012119. Epub 2022 Oct 13 doi: 10.3389/fendo.2022.1012119. PMID: 36313743Free PMC Article
Alder JK, Armanios M
Physiol Rev 2022 Oct 1;102(4):1703-1720. Epub 2022 May 9 doi: 10.1152/physrev.00046.2021. PMID: 35532056Free PMC Article
Nix JS, Blakeley J, Rodriguez FJ
Acta Neuropathol 2020 Apr;139(4):625-641. Epub 2019 Apr 8 doi: 10.1007/s00401-019-02002-2. PMID: 30963251Free PMC Article
Shallis RM, Ahmad R, Zeidan AM
Eur J Haematol 2018 Dec;101(6):711-720. Epub 2018 Oct 10 doi: 10.1111/ejh.13153. PMID: 30055055

Therapy

Chen S, Gan D, Lin S, Zhong Y, Chen M, Zou X, Shao Z, Xiao G
Theranostics 2022;12(6):2722-2740. Epub 2022 Mar 6 doi: 10.7150/thno.71360. PMID: 35401820Free PMC Article
Akter J, Kamijo T
Biomolecules 2021 Jul 28;11(8) doi: 10.3390/biom11081112. PMID: 34439779Free PMC Article
Frank Y
Pediatr Neurol 2021 Sep;122:59-64. Epub 2021 Jun 16 doi: 10.1016/j.pediatrneurol.2021.06.002. PMID: 34325981
Bhaumik P, Bhattacharya M, Ghosh P, Ghosh S, Kumar Dey S
Mech Ageing Dev 2017 Jun;164:20-26. Epub 2017 Mar 19 doi: 10.1016/j.mad.2017.03.006. PMID: 28327364
Carracedo J, Ramírez R, Madueño JA, Soriano S, Rodríguez-Benot A, Rodríguez M, Martín-Malo A, Aljama P
Kidney Int Suppl 2002 May;(80):89-93. doi: 10.1046/j.1523-1755.61.s80.17.x. PMID: 11982820

Prognosis

Rolles B, Caballero-Oteyza A, Proietti M, Goldacker S, Warnatz K, Camacho-Ordonez N, Prader S, Schmid JP, Vieri M, Isfort S, Meyer R, Kirschner M, Brümmendorf TH, Beier F, Grimbacher B
Clin Immunol 2023 Dec;257:109837. Epub 2023 Nov 8 doi: 10.1016/j.clim.2023.109837. PMID: 37944684
Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Nonavinkere Srivatsan S, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, Walter MJ, Westervelt P, DiPersio JF, Ley TJ, Link DC
Blood Adv 2023 Aug 22;7(16):4586-4598. doi: 10.1182/bloodadvances.2023010156. PMID: 37339484Free PMC Article
Alder JK, Armanios M
Physiol Rev 2022 Oct 1;102(4):1703-1720. Epub 2022 May 9 doi: 10.1152/physrev.00046.2021. PMID: 35532056Free PMC Article
Ji J, Shen J, Xu Y, Xie M, Qian Q, Qiu T, Shi W, Ren D, Ma J, Liu W, Liu B
Cell Death Dis 2022 May 7;13(5):442. doi: 10.1038/s41419-022-04892-9. PMID: 35525855Free PMC Article
Karremann M, Neumaier-Probst E, Schlichtenbrede F, Beier F, Brümmendorf TH, Cremer FW, Bader P, Dürken M
Orphanet J Rare Dis 2020 Oct 23;15(1):299. doi: 10.1186/s13023-020-01553-y. PMID: 33097095Free PMC Article

Clinical prediction guides

Sidali S, Borie R, Sicre de Fontbrune F, El Husseini K, Rautou PE, Lainey E, Goria O, Crestani B, Cadranel J, Cottin V, Bunel V, Dumortier J, Jacquemin E, Reboux N, Hirschi S, Bourdin A, Meszaros M, Dharancy S, Hilaire S, Mallet V, Reynaud-Gaubert M, Terriou L, Gottrand F, Abou Chahla W, Khan JE, Carrier P, Saliba F, Rubbia-Brandt L, Aubert JD, Elkrief L, de Lédinghen V, Abergel A, Olivier T, Houssel P, Jouneau S, Wemeau L, Bergeron A, Leblanc T, Ollivier-Hourmand I, Nguyen Khac E, Morisse-Pradier H, Ba I, Boileau C, Roudot-Thoraval F, Vilgrain V, Bureau C, Nunes H, Naccache JM, Durand F, Francoz C, Roulot D, Valla D, Paradis V, Kannengiesser C, Plessier A
Hepatology 2024 Jun 1;79(6):1365-1380. Epub 2023 Nov 6 doi: 10.1097/HEP.0000000000000667. PMID: 37934624
Gentiluomo M, Luddi A, Cingolani A, Fornili M, Governini L, Lucenteforte E, Baglietto L, Piomboni P, Campa D
Int J Mol Sci 2021 Apr 12;22(8) doi: 10.3390/ijms22083959. PMID: 33921254Free PMC Article
Akincilar SC, Chan CHT, Ng QF, Fidan K, Tergaonkar V
Cell Mol Life Sci 2021 May;78(9):4235-4257. Epub 2021 Feb 18 doi: 10.1007/s00018-021-03783-0. PMID: 33599797Free PMC Article
Alter BP, Giri N, Savage SA, Rosenberg PS
Blood 2009 Jun 25;113(26):6549-57. Epub 2009 Mar 12 doi: 10.1182/blood-2008-12-192880. PMID: 19282459Free PMC Article
Vulliamy T, Dokal I
Semin Hematol 2006 Jul;43(3):157-66. doi: 10.1053/j.seminhematol.2006.04.001. PMID: 16822458

Recent systematic reviews

Yamashita H, Arakawa Y, Terada Y, Takeuchi Y, Mineharu Y, Sumiyoshi S, Tokunaga S, Nakajima K, Kawabata N, Tanaka K, Tanji M, Umeda K, Minamiguchi S, Ogawa S, Haga H, Takita J, Miyamoto S
Brain Tumor Pathol 2022 Oct;39(4):232-239. Epub 2022 Jun 24 doi: 10.1007/s10014-022-00440-7. PMID: 35750988
Wang P, Xu Z
BMC Pulm Med 2021 Sep 3;21(1):279. doi: 10.1186/s12890-021-01645-w. PMID: 34479523Free PMC Article
Mitz AR, Philyaw TJ, Boccuto L, Shcheglovitov A, Sarasua SM, Kaufmann WE, Thurm A
Eur J Hum Genet 2018 Mar;26(3):293-302. Epub 2018 Jan 22 doi: 10.1038/s41431-017-0042-x. PMID: 29358616Free PMC Article
Barbaro P, Vedi A
Biol Blood Marrow Transplant 2016 Jul;22(7):1152-1158. Epub 2016 Mar 8 doi: 10.1016/j.bbmt.2016.03.001. PMID: 26968789
Gunes S, Hekim GN, Arslan MA, Asci R
J Assist Reprod Genet 2016 Apr;33(4):441-54. Epub 2016 Feb 11 doi: 10.1007/s10815-016-0663-y. PMID: 26867640Free PMC Article

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