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Abnormal mitral valve annulus morphology

MedGen UID:
1625860
•Concept ID:
C4531096
•
Anatomical Abnormality
HPO: HP:0031478

Definition

Any structural anomaly of the annulus of the mitral valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal mitral valve annulus morphology

Professional guidelines

PubMed

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ
Eur Heart J 2018 Apr 14;39(15):1269-1277. doi: 10.1093/eurheartj/ehx505. PMID: 29020406Free PMC Article
Cardiovascular characteristics in Marfan syndrome and their relation to the genotype.
De Backer J
Verh K Acad Geneeskd Belg 2009;71(6):335-71. PMID: 20232788
Recent developments in the diagnosis and management of mitral valve prolapse.
Devereux RB
Curr Opin Cardiol 1995 Mar;10(2):107-16. doi: 10.1097/00001573-199503000-00003. PMID: 7787275

Recent clinical studies

Etiology

Infant Mitral Valve Replacement: Current State of the Art.
Overman DM, Moga FX, Stephens EH, Dearani JA, MacIver RH
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2023;26:75-80. Epub 2023 Jan 16 doi: 10.1053/j.pcsu.2023.01.001. PMID: 36842801
Mitral Valve Prolapse and Sudden Cardiac Death in Athletes at High Risk.
Vriz O, Landi I, Eltayeb A, Limongelli G, Mos L, Delise P, Bossone E, D Andrea A
Curr Cardiol Rev 2023;19(3):e201222212066. doi: 10.2174/1573403X19666221220163431. PMID: 36545732Free PMC Article
Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death.
Basso C, Iliceto S, Thiene G, Perazzolo Marra M
Circulation 2019 Sep 10;140(11):952-964. Epub 2019 Sep 9 doi: 10.1161/CIRCULATIONAHA.118.034075. PMID: 31498700
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Borderline left ventricle.
Corno AF
Eur J Cardiothorac Surg 2005 Jan;27(1):67-73. doi: 10.1016/j.ejcts.2004.10.034. PMID: 15621473

Diagnosis

New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ
Eur Heart J 2018 Apr 14;39(15):1269-1277. doi: 10.1093/eurheartj/ehx505. PMID: 29020406Free PMC Article
Mitral Annulus Calcification.
Abramowitz Y, Jilaihawi H, Chakravarty T, Mack MJ, Makkar RR
J Am Coll Cardiol 2015 Oct 27;66(17):1934-41. doi: 10.1016/j.jacc.2015.08.872. PMID: 26493666
Pitfalls in repair of conotruncal anomalies.
Raisky O, Vouhé PR
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2013;16(1):7-12. doi: 10.1053/j.pcsu.2013.02.001. PMID: 23561812
Contemporary imaging of normal mitral valve anatomy and function.
Debonnaire P, Palmen M, Marsan NA, Delgado V
Curr Opin Cardiol 2012 Sep;27(5):455-64. doi: 10.1097/HCO.0b013e328354d7b5. PMID: 22820102
Recent developments in the diagnosis and management of mitral valve prolapse.
Devereux RB
Curr Opin Cardiol 1995 Mar;10(2):107-16. doi: 10.1097/00001573-199503000-00003. PMID: 7787275

Therapy

Short-term results in infants with multiple left heart obstructive lesions.
Steele JM, Komarlu R, Worley S, Alsaied T, Statile C, Erenberg FG
Congenit Heart Dis 2019 Nov;14(6):1193-1198. Epub 2019 Sep 6 doi: 10.1111/chd.12829. PMID: 31489778
Pitfalls in repair of conotruncal anomalies.
Raisky O, Vouhé PR
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2013;16(1):7-12. doi: 10.1053/j.pcsu.2013.02.001. PMID: 23561812
Principles of aortic valve repair.
El Khoury G, de Kerchove L
J Thorac Cardiovasc Surg 2013 Mar;145(3 Suppl):S26-9. Epub 2012 Dec 20 doi: 10.1016/j.jtcvs.2012.11.071. PMID: 23260436
Outcomes of aortic valve repair according to valve morphology and surgical techniques.
Fattouch K, Murana G, Castrovinci S, Nasso G, Mossuto C, Corrado E, Ruvolo G, Speziale G
Interact Cardiovasc Thorac Surg 2012 Oct;15(4):644-50. Epub 2012 Jul 3 doi: 10.1093/icvts/ivs195. PMID: 22761124Free PMC Article
Outcomes and associated risk factors for mitral valve replacement in children.
Alsoufi B, Manlhiot C, Al-Ahmadi M, McCrindle BW, Kalloghlian A, Siblini G, Bulbul Z, Al-Halees Z
Eur J Cardiothorac Surg 2011 Sep;40(3):543-51. Epub 2011 Feb 25 doi: 10.1016/j.ejcts.2010.12.060. PMID: 21353791

Prognosis

Infant Mitral Valve Replacement: Current State of the Art.
Overman DM, Moga FX, Stephens EH, Dearani JA, MacIver RH
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2023;26:75-80. Epub 2023 Jan 16 doi: 10.1053/j.pcsu.2023.01.001. PMID: 36842801
Mitral Valve Prolapse and Sudden Cardiac Death in Athletes at High Risk.
Vriz O, Landi I, Eltayeb A, Limongelli G, Mos L, Delise P, Bossone E, D Andrea A
Curr Cardiol Rev 2023;19(3):e201222212066. doi: 10.2174/1573403X19666221220163431. PMID: 36545732Free PMC Article
Mitral Valve Prolapse, Ventricular Arrhythmias, and Sudden Death.
Basso C, Iliceto S, Thiene G, Perazzolo Marra M
Circulation 2019 Sep 10;140(11):952-964. Epub 2019 Sep 9 doi: 10.1161/CIRCULATIONAHA.118.034075. PMID: 31498700
New insights into mitral valve dystrophy: a Filamin-A genotype-phenotype and outcome study.
Le Tourneau T, Le Scouarnec S, Cueff C, Bernstein D, Aalberts JJJ, Lecointe S, Mérot J, Bernstein JA, Oomen T, Dina C, Karakachoff M, Desal H, Al Habash O, Delling FN, Capoulade R, Suurmeijer AJH, Milan D, Norris RA, Markwald R, Aikawa E, Slaugenhaupt SA, Jeunemaitre X, Hagège A, Roussel JC, Trochu JN, Levine RA, Kyndt F, Probst V, Le Marec H, Schott JJ
Eur Heart J 2018 Apr 14;39(15):1269-1277. doi: 10.1093/eurheartj/ehx505. PMID: 29020406Free PMC Article
Pitfalls in repair of conotruncal anomalies.
Raisky O, Vouhé PR
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2013;16(1):7-12. doi: 10.1053/j.pcsu.2013.02.001. PMID: 23561812

Clinical prediction guides

Morphology of the mural and commissural atrioventricular junction of the mitral valve.
Krawczyk-Ożóg A, Batko J, Zdzierak B, Dziewierz A, Tyrak K, Bolechała F, Kopacz P, Strona M, Gil K, Hołda J, Hołda MK
Heart 2024 Mar 12;110(7):517-522. doi: 10.1136/heartjnl-2023-322965. PMID: 37935571
Infant Mitral Valve Replacement: Current State of the Art.
Overman DM, Moga FX, Stephens EH, Dearani JA, MacIver RH
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2023;26:75-80. Epub 2023 Jan 16 doi: 10.1053/j.pcsu.2023.01.001. PMID: 36842801
Morphology of Mitral Annular Disjunction in Mitral Valve Prolapse.
Faletra FF, Leo LA, Paiocchi VL, Schlossbauer SA, Pavon AG, Ho SY, Maisano F
J Am Soc Echocardiogr 2022 Feb;35(2):176-186. Epub 2021 Sep 8 doi: 10.1016/j.echo.2021.09.002. PMID: 34508838
Aortic elasticity and the influence of valve morphology in children with bicuspid aortic valve.
Erolu E, Akalın F, Çetiner N, Şaylan BÇ
Cardiol Young 2018 Nov;28(11):1338-1344. Epub 2018 Aug 6 doi: 10.1017/S1047951118001348. PMID: 30079852
Morphologic variability of the mitral valve leaflets.
Krawczyk-Ożóg A, Hołda MK, Sorysz D, Koziej M, Siudak Z, Dudek D, Klimek-Piotrowska W
J Thorac Cardiovasc Surg 2017 Dec;154(6):1927-1935. Epub 2017 Aug 16 doi: 10.1016/j.jtcvs.2017.07.067. PMID: 28893395

Recent systematic reviews

Mitral annular disjunction: A systematic review of the literature.
Bennett S, Thamman R, Griffiths T, Oxley C, Khan JN, Phan T, Patwala A, Heatlie G, Kwok CS
Echocardiography 2019 Aug;36(8):1549-1558. Epub 2019 Aug 5 doi: 10.1111/echo.14437. PMID: 31385360

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