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Abnormal nasal mucus secretion

MedGen UID:
1622043
•Concept ID:
C4531028
•
Finding
HPO: HP:0031416

Definition

Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal nasal mucus secretion

Professional guidelines

PubMed

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients.
Zhao X, Ge H, Xu W, Cheng C, Zhou W, Xu Y, Fan J, Liu Y, Tian X, Xu KF, Zhang X
Front Med 2023 Dec;17(6):1236-1249. Epub 2023 Sep 19 doi: 10.1007/s11684-023-0997-7. PMID: 37725231
Aspirin-induced asthma: clinical aspects, pathogenesis and management.
Hamad AM, Sutcliffe AM, Knox AJ
Drugs 2004;64(21):2417-32. doi: 10.2165/00003495-200464210-00004. PMID: 15482000
Medical treatment of sinusitis.
Baroody FM
J Med Liban 1994;42(4):190-5. PMID: 8558575

Recent clinical studies

Etiology

Differential Chloride Secretory Capacity in Transepithelial Ion Transport Properties in Chronic Rhinosinusitis.
McCormick J, Hoffman K, Thompson H, Skinner D, Zhang S, Grayson J, Illek B, Cho DY, Woodworth BA
Am J Rhinol Allergy 2020 Nov;34(6):830-837. Epub 2020 Jun 23 doi: 10.1177/1945892420930975. PMID: 32576027Free PMC Article
Mucins, Mucus, and Goblet Cells.
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Two holes syndrome (THS) is present in more than half of the postnasal drip patients?
Mladina R, Skitarelić N, Casale M
Acta Otolaryngol 2010 Nov;130(11):1274-7. doi: 10.3109/00016489.2010.480983. PMID: 20450396
Impaired mucosal healing and infection associated with Staphylococcus aureus after endoscopic sinus surgery.
Jervis-Bardy J, Foreman A, Field J, Wormald PJ
Am J Rhinol Allergy 2009 Sep-Oct;23(5):549-52. doi: 10.2500/ajra.2009.23.3366. PMID: 19807992
Ectodermal dysplasia: the otolaryngologic manifestations and management.
Siegel MB, Potsic WP
Int J Pediatr Otorhinolaryngol 1990 Aug;19(3):265-71. doi: 10.1016/0165-5876(90)90006-d. PMID: 2210953

Diagnosis

Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients.
Zhao X, Ge H, Xu W, Cheng C, Zhou W, Xu Y, Fan J, Liu Y, Tian X, Xu KF, Zhang X
Front Med 2023 Dec;17(6):1236-1249. Epub 2023 Sep 19 doi: 10.1007/s11684-023-0997-7. PMID: 37725231
Impaired mucosal healing and infection associated with Staphylococcus aureus after endoscopic sinus surgery.
Jervis-Bardy J, Foreman A, Field J, Wormald PJ
Am J Rhinol Allergy 2009 Sep-Oct;23(5):549-52. doi: 10.2500/ajra.2009.23.3366. PMID: 19807992
Sinusitis--inspecting the causes and treatment.
Yonkers AJ
Ear Nose Throat J 1992 Jun;71(6):258-62. PMID: 1451672
Nasal mucus clearance.
Golhar S
J Laryngol Otol 1986 May;100(5):533-8. doi: 10.1017/s0022215100099631. PMID: 3486240
Nasal obstruction.
Paisner HM
Postgrad Med 1972 Aug;52(2):88-92. doi: 10.1080/00325481.1972.11713207. PMID: 4403046

Therapy

Aspirin-induced asthma: clinical aspects, pathogenesis and management.
Hamad AM, Sutcliffe AM, Knox AJ
Drugs 2004;64(21):2417-32. doi: 10.2165/00003495-200464210-00004. PMID: 15482000
Medical treatment of sinusitis.
Baroody FM
J Med Liban 1994;42(4):190-5. PMID: 8558575
Abnormalities of taste and smell in Sjogren's syndrome.
Henkin RI, Talal N, Larson AL, Mattern CF
Ann Intern Med 1972 Mar;76(3):375-83. doi: 10.7326/0003-4819-76-3-375. PMID: 5015912
Nasal obstruction.
Paisner HM
Postgrad Med 1972 Aug;52(2):88-92. doi: 10.1080/00325481.1972.11713207. PMID: 4403046
Sinusitis in children with cleft lip and palate.
Jaffe BF, DeBlanc CB
Arch Otolaryngol 1971 May;93(5):479-82. doi: 10.1001/archotol.1971.00770060725007. PMID: 5554882

Prognosis

Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex.
Olbrich H, Cremers C, Loges NT, Werner C, Nielsen KG, Marthin JK, Philipsen M, Wallmeier J, Pennekamp P, Menchen T, Edelbusch C, Dougherty GW, Schwartz O, Thiele H, Altmüller J, Rommelmann F, Omran H
Am J Hum Genet 2015 Oct 1;97(4):546-54. Epub 2015 Sep 17 doi: 10.1016/j.ajhg.2015.08.012. PMID: 26387594Free PMC Article
Two holes syndrome (THS) is present in more than half of the postnasal drip patients?
Mladina R, Skitarelić N, Casale M
Acta Otolaryngol 2010 Nov;130(11):1274-7. doi: 10.3109/00016489.2010.480983. PMID: 20450396
Impaired mucosal healing and infection associated with Staphylococcus aureus after endoscopic sinus surgery.
Jervis-Bardy J, Foreman A, Field J, Wormald PJ
Am J Rhinol Allergy 2009 Sep-Oct;23(5):549-52. doi: 10.2500/ajra.2009.23.3366. PMID: 19807992
Nasal mucus clearance.
Golhar S
J Laryngol Otol 1986 May;100(5):533-8. doi: 10.1017/s0022215100099631. PMID: 3486240
Bronchopulmonary symptoms in primary ciliary dyskinesia. A clinical study of 27 patients.
Pedersen M, Stafanger G
Eur J Respir Dis Suppl 1983;127:118-28. PMID: 6604644

Clinical prediction guides

Mucus composition abnormalities in sinonasal mucosa of chronic rhinosinusitis with and without nasal polyps.
Tu Y, Liu J, Li T, Zhou X, Tan KS, Ong HH, Sun K, Ouyang Y, Liang X, Ong YK, Thong M, Shi L, Wang DY
Inflammation 2021 Oct;44(5):1937-1948. Epub 2021 May 17 doi: 10.1007/s10753-021-01471-6. PMID: 33999330
Mucins, Mucus, and Goblet Cells.
Ma J, Rubin BK, Voynow JA
Chest 2018 Jul;154(1):169-176. Epub 2017 Nov 21 doi: 10.1016/j.chest.2017.11.008. PMID: 29170036
Impaired mucosal healing and infection associated with Staphylococcus aureus after endoscopic sinus surgery.
Jervis-Bardy J, Foreman A, Field J, Wormald PJ
Am J Rhinol Allergy 2009 Sep-Oct;23(5):549-52. doi: 10.2500/ajra.2009.23.3366. PMID: 19807992
The CF salt controversy: in vivo observations and therapeutic approaches.
Tarran R, Grubb BR, Parsons D, Picher M, Hirsh AJ, Davis CW, Boucher RC
Mol Cell 2001 Jul;8(1):149-58. doi: 10.1016/s1097-2765(01)00286-6. PMID: 11511368
Experimental infection of human nasal mucosal explants with Neisseria meningitidis.
Read RC, Fox A, Miller K, Gray T, Jones N, Borrows R, Jones DM, Finch RG
J Med Microbiol 1995 May;42(5):353-61. doi: 10.1099/00222615-42-5-353. PMID: 7752215

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