Periorbital purpura

MedGen UID:: 1619276
•Concept ID:: C4531295
•: Finding

HPO:	HP:0025552

Definition

Multiple red/purple spots on the skin that surrounds the eyes that do not blanch (whiten) upon pressure. Purpura is caused by subcutaneous bleeding. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPeriorbital purpura

Phenotypic abnormality
- Abnormality of head or neck
  - Abnormality of the head
    - Abnormality of the face
      - Abnormality of the periorbital region
        Periorbital purpura

Professional guidelines

PubMed

Treatment of face veins with a cryogen spray variable pulse width 1064 nm Nd:YAG Laser: a prospective study of 17 patients.

Eremia S, Li CY
Dermatol Surg 2002 Mar;28(3):244-7. doi: 10.1046/j.1524-4725.2002.01217.x. PMID: 11896777

Treatment of vascular lesions with combined dynamic precooling, postcooling thermal quenching, and ND:YAG 1,064-nm laser.

Pham RT
Facial Plast Surg 2001 Aug;17(3):203-8. doi: 10.1055/s-2001-17968. PMID: 11673810

See all (2)

Recent clinical studies

Etiology

When to Suspect a Diagnosis of Amyloidosis.

Vaxman I, Gertz M
Acta Haematol 2020;143(4):304-311. Epub 2020 Apr 27 doi: 10.1159/000506617. PMID: 32340017

Amyloidosis as a Systemic Disease in Context.

Cuddy SAM, Falk RH
Can J Cardiol 2020 Mar;36(3):396-407. Epub 2020 Jan 17 doi: 10.1016/j.cjca.2019.12.033. PMID: 32145867

Sertraline-induced periorbital purpura: a case report.

Kayhan F, Eken ZE, Uguz F
Australas Psychiatry 2015 Aug;23(4):426-8. Epub 2015 May 11 doi: 10.1177/1039856215586138. PMID: 25964653

Imatinib-induced postoperative periorbital purpura: GASP (Gleevec-Associated Surgical Purpura) in a woman with imatinib-treated chronic myelogenous leukemia.

Anzalone CL, Cohen PR, Kurzrock R, Cortes JE
Dermatol Online J 2014 Jan 15;20(1):21242. PMID: 24456946

See all (4)

Diagnosis

Periorbital purpura of AL amyloidosis.

Chen-Xu M, Achilleos K
Rheumatology (Oxford) 2021 Mar 2;60(3):1165. doi: 10.1093/rheumatology/keaa545. PMID: 32944781

When to Suspect a Diagnosis of Amyloidosis.

Vaxman I, Gertz M
Acta Haematol 2020;143(4):304-311. Epub 2020 Apr 27 doi: 10.1159/000506617. PMID: 32340017

Amyloidosis as a Systemic Disease in Context.

Cuddy SAM, Falk RH
Can J Cardiol 2020 Mar;36(3):396-407. Epub 2020 Jan 17 doi: 10.1016/j.cjca.2019.12.033. PMID: 32145867

Acute Periorbital Rash.

Sil A, Bhanja DB, Panigrahi A, Chakraborty S
J Pediatr 2020 Feb;217:212. Epub 2019 Nov 1 doi: 10.1016/j.jpeds.2019.09.080. PMID: 31685229

Periorbital purpura (raccoon's eyes).

Pereira VG, Jacinto M, Santos J, de Abreu TT
BMJ Case Rep 2014 Aug 19;2014 doi: 10.1136/bcr-2013-201407. PMID: 25139913 Free PMC Article

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Therapy

A 64-year-old woman with raccoon eyes following kidney biopsy: a case report.

Mei S, Zhao Y, Li L, Mei C, Dai B
BMC Nephrol 2020 Apr 17;21(1):140. doi: 10.1186/s12882-020-01770-4. PMID: 32303194 Free PMC Article

Sertraline-induced periorbital purpura: a case report.

Kayhan F, Eken ZE, Uguz F
Australas Psychiatry 2015 Aug;23(4):426-8. Epub 2015 May 11 doi: 10.1177/1039856215586138. PMID: 25964653

Imatinib-induced postoperative periorbital purpura: GASP (Gleevec-Associated Surgical Purpura) in a woman with imatinib-treated chronic myelogenous leukemia.

Anzalone CL, Cohen PR, Kurzrock R, Cortes JE
Dermatol Online J 2014 Jan 15;20(1):21242. PMID: 24456946

Periorbital ecchymoses during general anesthesia in a patient with primary amyloidosis: a harbinger for bleeding?

Weingarten TN, Hall BA, Richardson BF, Hofer RE, Sprung J
Anesth Analg 2007 Dec;105(6):1561-3, table of contents. doi: 10.1213/01.ane.0000290304.02125.6e. PMID: 18042847

See all (4)