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Abnormal ventricular myocardium morphology

MedGen UID:
1617610
•Concept ID:
C4531205
•
Anatomical Abnormality
HPO: HP:0031316

Definition

A structural anomaly of the muscle layer of the heart wall of a cardiac ventricle. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal ventricular myocardium morphology

Professional guidelines

PubMed

Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Presentation, diagnosis, and medical management of heart failure in children: Canadian Cardiovascular Society guidelines.
Kantor PF, Lougheed J, Dancea A, McGillion M, Barbosa N, Chan C, Dillenburg R, Atallah J, Buchholz H, Chant-Gambacort C, Conway J, Gardin L, George K, Greenway S, Human DG, Jeewa A, Price JF, Ross RD, Roche SL, Ryerson L, Soni R, Wilson J, Wong K; Children's Heart Failure Study Group
Can J Cardiol 2013 Dec;29(12):1535-52. doi: 10.1016/j.cjca.2013.08.008. PMID: 24267800
Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria.
Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W
Eur Heart J 2010 Apr;31(7):806-14. Epub 2010 Feb 19 doi: 10.1093/eurheartj/ehq025. PMID: 20172912Free PMC Article

Recent clinical studies

Etiology

Cardiomyopathies in children: An overview.
Tsatsopoulou A, Protonotarios I, Xylouri Z, Papagiannis I, Anastasakis A, Germanakis I, Patrianakos A, Nyktari E, Gavras C, Papadopoulos G, Meditskou S, Lazarou E, Miliou A, Lazaros G
Hellenic J Cardiol 2023 Jul-Aug;72:43-56. Epub 2023 Mar 3 doi: 10.1016/j.hjc.2023.02.007. PMID: 36870438
The Keystones of Right Ventricular Arrhythmogenic Cardiomyopathy-Induced Morphological Disarrangement.
Avagimyan A, Kakturskiy L, Gogiashvili L, Aznauryan A
Curr Probl Cardiol 2022 May;47(5):101133. Epub 2022 Jan 31 doi: 10.1016/j.cpcardiol.2022.101133. PMID: 35114294
Hypertrabeculation; a phenotype with Heterogeneous etiology.
Adabifirouzjaei F, Igata S, DeMaria AN
Prog Cardiovasc Dis 2021 Sep-Oct;68:60-69. Epub 2021 Jul 13 doi: 10.1016/j.pcad.2021.07.007. PMID: 34265334
Reevaluation of genetic variants previously associated with arrhythmogenic right ventricular cardiomyopathy integrating population-based cohorts and proteomics data.
Ye JZ, Delmar M, Lundby A, Olesen MS
Clin Genet 2019 Dec;96(6):506-514. Epub 2019 Aug 19 doi: 10.1111/cge.13621. PMID: 31402444
Recent advances in cirrhotic cardiomyopathy.
Karagiannakis DS, Papatheodoridis G, Vlachogiannakos J
Dig Dis Sci 2015 May;60(5):1141-51. Epub 2014 Nov 18 doi: 10.1007/s10620-014-3432-8. PMID: 25404411

Diagnosis

The Keystones of Right Ventricular Arrhythmogenic Cardiomyopathy-Induced Morphological Disarrangement.
Avagimyan A, Kakturskiy L, Gogiashvili L, Aznauryan A
Curr Probl Cardiol 2022 May;47(5):101133. Epub 2022 Jan 31 doi: 10.1016/j.cpcardiol.2022.101133. PMID: 35114294
Cardiac imaging in Ebstein anomaly.
Qureshi MY, O'Leary PW, Connolly HM
Trends Cardiovasc Med 2018 Aug;28(6):403-409. Epub 2018 Jan 12 doi: 10.1016/j.tcm.2018.01.002. PMID: 29409687
Recent advances in cirrhotic cardiomyopathy.
Karagiannakis DS, Papatheodoridis G, Vlachogiannakos J
Dig Dis Sci 2015 May;60(5):1141-51. Epub 2014 Nov 18 doi: 10.1007/s10620-014-3432-8. PMID: 25404411
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D).
Iyer VR, Chin AJ
Am J Med Genet C Semin Med Genet 2013 Aug;163C(3):185-97. Epub 2013 Jul 3 doi: 10.1002/ajmg.c.31368. PMID: 23824749
Left ventricular hypertrabeculation/noncompaction.
Stöllberger C, Finsterer J
J Am Soc Echocardiogr 2004 Jan;17(1):91-100. doi: 10.1016/S0894-7317(03)00514-5. PMID: 14712196

Therapy

Diagnosis and Treatment of Acute Myocarditis: A Review.
Ammirati E, Moslehi JJ
JAMA 2023 Apr 4;329(13):1098-1113. doi: 10.1001/jama.2023.3371. PMID: 37014337
Impact of peroxisome proliferator-activated receptor-α on diabetic cardiomyopathy.
Wang L, Cai Y, Jian L, Cheung CW, Zhang L, Xia Z
Cardiovasc Diabetol 2021 Jan 4;20(1):2. doi: 10.1186/s12933-020-01188-0. PMID: 33397369Free PMC Article
The effects of endurance exercise on the heart: panacea or poison?
Parry-Williams G, Sharma S
Nat Rev Cardiol 2020 Jul;17(7):402-412. Epub 2020 Mar 9 doi: 10.1038/s41569-020-0354-3. PMID: 32152528
Arrhythmogenic Cardiomyopathy.
Corrado D, Basso C, Judge DP
Circ Res 2017 Sep 15;121(7):784-802. doi: 10.1161/CIRCRESAHA.117.309345. PMID: 28912183
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE
Science 2016 Feb 5;351(6273):617-21. doi: 10.1126/science.aad3456. PMID: 26912705Free PMC Article

Prognosis

Arrhythmogenic right ventricular cardiomyopathy in dogs.
Cunningham SM, Dos Santos L
J Vet Cardiol 2022 Apr;40:156-169. Epub 2021 Jul 23 doi: 10.1016/j.jvc.2021.07.001. PMID: 34503916
Cardiac imaging in Ebstein anomaly.
Qureshi MY, O'Leary PW, Connolly HM
Trends Cardiovasc Med 2018 Aug;28(6):403-409. Epub 2018 Jan 12 doi: 10.1016/j.tcm.2018.01.002. PMID: 29409687
Pediatric Cardiomyopathies.
Lee TM, Hsu DT, Kantor P, Towbin JA, Ware SM, Colan SD, Chung WK, Jefferies JL, Rossano JW, Castleberry CD, Addonizio LJ, Lal AK, Lamour JM, Miller EM, Thrush PT, Czachor JD, Razoky H, Hill A, Lipshultz SE
Circ Res 2017 Sep 15;121(7):855-873. doi: 10.1161/CIRCRESAHA.116.309386. PMID: 28912187Free PMC Article
Arrhythmogenic Cardiomyopathy.
Corrado D, Basso C, Judge DP
Circ Res 2017 Sep 15;121(7):784-802. doi: 10.1161/CIRCRESAHA.117.309345. PMID: 28912183
Cirrhotic cardiomyopathy.
Ruiz-del-Árbol L, Serradilla R
World J Gastroenterol 2015 Nov 7;21(41):11502-21. doi: 10.3748/wjg.v21.i41.11502. PMID: 26556983Free PMC Article

Clinical prediction guides

Morphology of Mitral Annular Disjunction in Mitral Valve Prolapse.
Faletra FF, Leo LA, Paiocchi VL, Schlossbauer SA, Pavon AG, Ho SY, Maisano F
J Am Soc Echocardiogr 2022 Feb;35(2):176-186. Epub 2021 Sep 8 doi: 10.1016/j.echo.2021.09.002. PMID: 34508838
Hypertrabeculation; a phenotype with Heterogeneous etiology.
Adabifirouzjaei F, Igata S, DeMaria AN
Prog Cardiovasc Dis 2021 Sep-Oct;68:60-69. Epub 2021 Jul 13 doi: 10.1016/j.pcad.2021.07.007. PMID: 34265334
Cardiac imaging in Ebstein anomaly.
Qureshi MY, O'Leary PW, Connolly HM
Trends Cardiovasc Med 2018 Aug;28(6):403-409. Epub 2018 Jan 12 doi: 10.1016/j.tcm.2018.01.002. PMID: 29409687
Arrhythmogenic Cardiomyopathy.
Corrado D, Basso C, Judge DP
Circ Res 2017 Sep 15;121(7):784-802. doi: 10.1161/CIRCRESAHA.117.309345. PMID: 28912183
Arrhythmogenic right ventricular dysplasia/cardiomyopathy.
El Masry HZ, Yadav AV
Expert Rev Cardiovasc Ther 2008 Feb;6(2):249-60. doi: 10.1586/14779072.6.2.249. PMID: 18248278

Recent systematic reviews

Arrhythmogenic Right Ventricular Cardiomyopathy Post-Mortem Assessment: A Systematic Review.
Cianci V, Forzese E, Sapienza D, Cianci A, Ieni A, Germanà A, Guerrera MC, Omero F, Speranza D, Cracò A, Asmundo A, Gualniera P, Mondello C
Int J Mol Sci 2024 Feb 20;25(5) doi: 10.3390/ijms25052467. PMID: 38473714Free PMC Article
Electroanatomic voltage mapping for tissue characterization beyond arrhythmia definition: A systematic review.
Zoppo F, Gagno G, Perazza L, Cocciolo A, Mugnai G, Vaccari D, Calzolari V
Pacing Clin Electrophysiol 2021 Aug;44(8):1432-1448. Epub 2021 Jun 23 doi: 10.1111/pace.14288. PMID: 34096635
Myocardial bridges: A meta-analysis.
Roberts W, Charles SM, Ang C, Holda MK, Walocha J, Lachman N, Tubbs RS, Loukas M
Clin Anat 2021 Jul;34(5):685-709. Epub 2021 Feb 22 doi: 10.1002/ca.23697. PMID: 33078444
The efficacy and safety of electroanatomic mapping-guided endomyocardial biopsy: a systematic review.
Vaidya VR, Abudan AA, Vasudevan K, Shantha G, Cooper LT, Kapa S, Noseworthy PA, Cha YM, Asirvatham SJ, Deshmukh AJ
J Interv Card Electrophysiol 2018 Oct;53(1):63-71. Epub 2018 Jul 12 doi: 10.1007/s10840-018-0410-7. PMID: 30003460
Sudden cardiac death owing to arrhythmogenic right ventricular cardiomyopathy: Two case reports and systematic literature review.
Mu J, Zhang G, Xue D, Xi M, Qi J, Dong H
Medicine (Baltimore) 2017 Nov;96(47):e8808. doi: 10.1097/MD.0000000000008808. PMID: 29381985Free PMC Article

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