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Reduced granulocyte surface marker level

MedGen UID:
1616688
•Concept ID:
C4531047
•
Finding
HPO: HP:0031553

Definition

Reduced level of a protein that is normally present on the granulocyte surface as assessed by flow cytometry. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced granulocyte surface marker level

Professional guidelines

PubMed

Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media.
Khomtchouk KM, Joseph LI, Khomtchouk BB, Kouhi A, Massa S, Xia A, Koliesnik I, Pletzer D, Bollyky PL, Santa Maria PL
NPJ Biofilms Microbiomes 2021 Apr 6;7(1):31. doi: 10.1038/s41522-021-00200-z. PMID: 33824337Free PMC Article
Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis.
Lingblom C, Albinsson S, Johansson L, Larsson H, Wennerås C
Dig Dis Sci 2021 May;66(5):1556-1564. Epub 2020 Jun 3 doi: 10.1007/s10620-020-06368-2. PMID: 32495256Free PMC Article
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.
Ndlovu LN, Peetluk L, Moodley S, Nhamoyebonde S, Ngoepe AT, Mazibuko M, Khan K, Karim F, Pym AS, Maruri F, Moosa MS, van der Heijden YF, Sterling TR, Leslie A
Front Immunol 2020;11:1872. Epub 2020 Aug 28 doi: 10.3389/fimmu.2020.01872. PMID: 32983107Free PMC Article

Recent clinical studies

Etiology

Combinatorial macrophage induced innate immunotherapy against Ewing sarcoma: Turning "Two Keys" simultaneously.
Luo W, Hoang H, Miller KE, Zhu H, Xu S, Mo X, Garfinkle EAR, Costello H, Wijeratne S, Chemnitz W, Gandhi R, Liao Y, Ayello J, Gardenswartz A, Rosenblum JM, Cassady KA, Mardis ER, Lee DA, Cripe TP, Cairo MS
J Exp Clin Cancer Res 2024 Jul 11;43(1):193. doi: 10.1186/s13046-024-03093-w. PMID: 38992659Free PMC Article
Icosapent ethyl modulates circulating vascular regenerative cell content: The IPE-PREVENTION CardioLink-14 trial.
Bakbak E, Krishnaraj A, Bhatt DL, Quan A, Park B, Bakbak AI, Bari B, Terenzi KA, Pan Y, Fry EJ, Terenzi DC, Puar P, Khan TS, Rotstein OD, Mazer CD, Leiter LA, Teoh H, Hess DA, Verma S
Med 2024 Jul 12;5(7):718-734.e4. Epub 2024 Mar 28 doi: 10.1016/j.medj.2024.03.009. PMID: 38552629
E-cigarette vapor renders neutrophils dysfunctional due to filamentous actin accumulation.
Jasper AE, Faniyi AA, Davis LC, Grudzinska FS, Halston R, Hazeldine J, Parekh D, Sapey E, Thickett DR, Scott A
J Allergy Clin Immunol 2024 Jan;153(1):320-329.e8. Epub 2023 Sep 5 doi: 10.1016/j.jaci.2023.08.025. PMID: 37678576
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.
Ortiz-Espinosa S, Morales X, Senent Y, Alignani D, Tavira B, Macaya I, Ruiz B, Moreno H, Remírez A, Sainz C, Rodriguez-Pena A, Oyarbide A, Ariz M, Andueza MP, Valencia K, Teijeira A, Hoehlig K, Vater A, Rolfe B, Woodruff TM, Lopez-Picazo JM, Vicent S, Kochan G, Escors D, Gil-Bazo I, Perez-Gracia JL, Montuenga LM, Lambris JD, Ortiz de Solorzano C, Lecanda F, Ajona D, Pio R
Cancer Lett 2022 Mar 31;529:70-84. Epub 2021 Dec 28 doi: 10.1016/j.canlet.2021.12.027. PMID: 34971753
Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure.
Wu W, Sun S, Wang Y, Zhao R, Ren H, Li Z, Zhao H, Zhang Y, Sheng J, Chen Z, Shi Y
Front Immunol 2021;12:620365. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.620365. PMID: 33717119Free PMC Article

Diagnosis

Improving Glucocorticoid Sensitivity of Brain-Homing CD4(+) T Helper Cells by Steroid Hormone Crosstalk.
Koetzier SC, van Langelaar J, Wierenga-Wolf AF, Melief MJ, Pol K, Musters S, Lubberts E, Dik WA, Smolders J, van Luijn MM
Front Immunol 2022;13:893702. Epub 2022 May 26 doi: 10.3389/fimmu.2022.893702. PMID: 35693770Free PMC Article
Circulating Neutrophil Dysfunction in HBV-Related Acute-on-Chronic Liver Failure.
Wu W, Sun S, Wang Y, Zhao R, Ren H, Li Z, Zhao H, Zhang Y, Sheng J, Chen Z, Shi Y
Front Immunol 2021;12:620365. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.620365. PMID: 33717119Free PMC Article
Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis.
Lingblom C, Albinsson S, Johansson L, Larsson H, Wennerås C
Dig Dis Sci 2021 May;66(5):1556-1564. Epub 2020 Jun 3 doi: 10.1007/s10620-020-06368-2. PMID: 32495256Free PMC Article
Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study.
Hampson P, Dinsdale RJ, Wearn CM, Bamford AL, Bishop JRB, Hazeldine J, Moiemen NS, Harrison P, Lord JM
Ann Surg 2017 Jun;265(6):1241-1249. doi: 10.1097/SLA.0000000000001807. PMID: 27232244
Granulocyte activation in humans is modulated by psychological stress and relaxation.
Keresztes M, Rudisch T, Tajti J, Ocsovszki I, Gardi J
Stress 2007 Aug;10(3):271-81. doi: 10.1080/10253890701248079. PMID: 17613941

Therapy

Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer.
Calì B, Troiani M, Bressan S, Attanasio G, Merler S, Moscarda V, Mosole S, Ricci E, Guo C, Yuan W, Gallagher L, Lundberg A, Bernett I, Figueiredo I, Arzola RA, Abreut EB, D'Ambrosio M, Bancaro N, Brina D, Zumerle S, Pasquini E, Maddalena M, Lai P, Colucci M, Pernigoni N, Rinaldi A, Minardi D, Morlacco A, Moro FD, Sabbadin M, Galuppini F, Fassan M, Rüschoff JH, Moch H, Rescigno P, Francini E, Saieva C, Modesti M, Theurillat JP, Gillessen S, Wilgenbus P, Graf C, Ruf W, de Bono J, Alimonti A
Cancer Cell 2024 Oct 14;42(10):1676-1692.e11. Epub 2024 Sep 19 doi: 10.1016/j.ccell.2024.08.018. PMID: 39303726
Icosapent ethyl modulates circulating vascular regenerative cell content: The IPE-PREVENTION CardioLink-14 trial.
Bakbak E, Krishnaraj A, Bhatt DL, Quan A, Park B, Bakbak AI, Bari B, Terenzi KA, Pan Y, Fry EJ, Terenzi DC, Puar P, Khan TS, Rotstein OD, Mazer CD, Leiter LA, Teoh H, Hess DA, Verma S
Med 2024 Jul 12;5(7):718-734.e4. Epub 2024 Mar 28 doi: 10.1016/j.medj.2024.03.009. PMID: 38552629
E-cigarette vapor renders neutrophils dysfunctional due to filamentous actin accumulation.
Jasper AE, Faniyi AA, Davis LC, Grudzinska FS, Halston R, Hazeldine J, Parekh D, Sapey E, Thickett DR, Scott A
J Allergy Clin Immunol 2024 Jan;153(1):320-329.e8. Epub 2023 Sep 5 doi: 10.1016/j.jaci.2023.08.025. PMID: 37678576
Oral and Blood Neutrophil Activation States during Experimental Gingivitis.
Wellappuli NC, Fine N, Lawrence HP, Goldberg M, Tenenbaum HC, Glogauer M
JDR Clin Trans Res 2018 Jan;3(1):65-75. Epub 2017 Nov 20 doi: 10.1177/2380084417742120. PMID: 30938653
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630

Prognosis

Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19.
Mairpady Shambat S, Gómez-Mejia A, Schweizer TA, Huemer M, Chang CC, Acevedo C, Bergada-Pijuan J, Vulin C, Hofmaenner DA, Scheier TC, Hertegonne S, Parietti E, Miroshnikova N, Wendel Garcia PD, Hilty MP, Buehler PK, Schuepbach RA, Brugger SD, Zinkernagel AS
PLoS Pathog 2022 Jan;18(1):e1010176. Epub 2022 Jan 10 doi: 10.1371/journal.ppat.1010176. PMID: 35007290Free PMC Article
Patient-Reported Outcomes and Blood-Based Parameters Identify Response to Treatment in Eosinophilic Esophagitis.
Lingblom C, Albinsson S, Johansson L, Larsson H, Wennerås C
Dig Dis Sci 2021 May;66(5):1556-1564. Epub 2020 Jun 3 doi: 10.1007/s10620-020-06368-2. PMID: 32495256Free PMC Article
Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study.
Hampson P, Dinsdale RJ, Wearn CM, Bamford AL, Bishop JRB, Hazeldine J, Moiemen NS, Harrison P, Lord JM
Ann Surg 2017 Jun;265(6):1241-1249. doi: 10.1097/SLA.0000000000001807. PMID: 27232244
CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia.
Bertoli S, Boutzen H, David L, Larrue C, Vergez F, Fernandez-Vidal A, Yuan L, Hospital MA, Tamburini J, Demur C, Delabesse E, Saland E, Sarry JE, Galcera MO, Mansat-De Mas V, Didier C, Dozier C, Récher C, Manenti S
Oncotarget 2015 Nov 10;6(35):38061-78. doi: 10.18632/oncotarget.5706. PMID: 26515730Free PMC Article
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630

Clinical prediction guides

Icosapent ethyl modulates circulating vascular regenerative cell content: The IPE-PREVENTION CardioLink-14 trial.
Bakbak E, Krishnaraj A, Bhatt DL, Quan A, Park B, Bakbak AI, Bari B, Terenzi KA, Pan Y, Fry EJ, Terenzi DC, Puar P, Khan TS, Rotstein OD, Mazer CD, Leiter LA, Teoh H, Hess DA, Verma S
Med 2024 Jul 12;5(7):718-734.e4. Epub 2024 Mar 28 doi: 10.1016/j.medj.2024.03.009. PMID: 38552629
Anti-PD-L1 therapy altered inflammation but not survival in a lethal murine hepatitis virus-1 pneumonia model.
Curran CS, Cui X, Li Y, Jeakle M, Sun J, Demirkale CY, Minkove S, Hoffmann V, Dhamapurkar R, Chumbris S, Bolyard C, Iheanacho A, Eichacker PQ, Torabi-Parizi P
Front Immunol 2023;14:1308358. Epub 2024 Jan 8 doi: 10.3389/fimmu.2023.1308358. PMID: 38259435Free PMC Article
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19.
Mairpady Shambat S, Gómez-Mejia A, Schweizer TA, Huemer M, Chang CC, Acevedo C, Bergada-Pijuan J, Vulin C, Hofmaenner DA, Scheier TC, Hertegonne S, Parietti E, Miroshnikova N, Wendel Garcia PD, Hilty MP, Buehler PK, Schuepbach RA, Brugger SD, Zinkernagel AS
PLoS Pathog 2022 Jan;18(1):e1010176. Epub 2022 Jan 10 doi: 10.1371/journal.ppat.1010176. PMID: 35007290Free PMC Article
Bacteriophages immunomodulate the response of monocytes.
Perea L, Rodríguez-Rubio L, Nieto JC, Zamora C, Cantó E, Soriano G, Poca M, Blanco-Picazo P, Navarro F, Muniesa M, Vidal S
Exp Biol Med (Maywood) 2021 Jun;246(11):1263-1268. Epub 2021 Feb 27 doi: 10.1177/1535370221995154. PMID: 33641443Free PMC Article
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630

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