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MEK Family Gene Mutation

MedGen UID:
1614864
Concept ID:
C4526668
Cell or Molecular Dysfunction
Synonyms: MAP2K Family Gene Mutation; MAPKK Family Gene Mutation; MEK Family Mutation; MEK Mutation; Mitogen-Activated Protein Kinase Kinase Family Gene Mutation; Mutant MEK; Mutant MEK Family Gene

Definition

A change in the nucleotide sequence in a MEK family gene. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Aaroe A, Kurzrock R, Goyal G, Goodman AM, Patel H, Ruan G, Ulaner G, Young J, Li Z, Dustin D, Go RS, Diamond EL, Janku F
Blood Adv 2023 Aug 8;7(15):3984-3992. doi: 10.1182/bloodadvances.2022009013. PMID: 36857436Free PMC Article
Read J
Australas J Dermatol 2013 Aug;54(3):163-72. Epub 2013 Jan 18 doi: 10.1111/ajd.12013. PMID: 23330781
Romano E, Schwartz GK, Chapman PB, Wolchock JD, Carvajal RD
Lancet Oncol 2011 Sep;12(9):913-22. Epub 2011 Feb 23 doi: 10.1016/S1470-2045(10)70274-6. PMID: 21349766

Recent clinical studies

Etiology

Chen J, Xu X, Chen S, Lu T, Zheng Y, Gan Z, Shen Z, Ma S, Wang D, Su L, He F, Shang X, Xu H, Chen D, Zhang L, Xiong F
Int J Oral Sci 2023 Sep 26;15(1):46. doi: 10.1038/s41368-023-00244-1. PMID: 37752101Free PMC Article
Wadensten E, Wessman S, Abel F, Diaz De Ståhl T, Tesi B, Orsmark Pietras C, Arvidsson L, Taylan F, Fransson S, Vogt H, Poluha A, Pradhananga S, Hellberg M, Lagerstedt-Robinson K, Raj Somarajan P, Samuelsson S, Orrsjö S, Maqbool K, Henning K, Strid T, Ek T, Fagman H, Olsson Bontell T, Martinsson T, Puls F, Kogner P, Wirta V, Pronk CJ, Wille J, Rosenquist R, Nistér M, Mertens F, Sabel M, Norén-Nyström U, Grillner P, Nordgren A, Ljungman G, Sandgren J, Gisselsson D; Genomic Medicine Sweden Childhood Cancer Working Group
JCO Precis Oncol 2023 Jun;7:e2300039. doi: 10.1200/PO.23.00039. PMID: 37384868Free PMC Article
Aaroe A, Kurzrock R, Goyal G, Goodman AM, Patel H, Ruan G, Ulaner G, Young J, Li Z, Dustin D, Go RS, Diamond EL, Janku F
Blood Adv 2023 Aug 8;7(15):3984-3992. doi: 10.1182/bloodadvances.2022009013. PMID: 36857436Free PMC Article
Mansouri S, Suppiah S, Mamatjan Y, Paganini I, Liu JC, Karimi S, Patil V, Nassiri F, Singh O, Sundaravadanam Y, Rath P, Sestini R, Gensini F, Agnihotri S, Blakeley J, Ostrow K, Largaespada D, Plotkin SR, Stemmer-Rachamimov A, Ferrer MM, Pugh TJ, Aldape KD, Papi L, Zadeh G
Acta Neuropathol 2021 Jan;141(1):101-116. Epub 2020 Oct 6 doi: 10.1007/s00401-020-02230-x. PMID: 33025139Free PMC Article
Niemeyer CM
Haematologica 2014 Nov;99(11):1653-62. doi: 10.3324/haematol.2014.114595. PMID: 25420281Free PMC Article

Diagnosis

Wadensten E, Wessman S, Abel F, Diaz De Ståhl T, Tesi B, Orsmark Pietras C, Arvidsson L, Taylan F, Fransson S, Vogt H, Poluha A, Pradhananga S, Hellberg M, Lagerstedt-Robinson K, Raj Somarajan P, Samuelsson S, Orrsjö S, Maqbool K, Henning K, Strid T, Ek T, Fagman H, Olsson Bontell T, Martinsson T, Puls F, Kogner P, Wirta V, Pronk CJ, Wille J, Rosenquist R, Nistér M, Mertens F, Sabel M, Norén-Nyström U, Grillner P, Nordgren A, Ljungman G, Sandgren J, Gisselsson D; Genomic Medicine Sweden Childhood Cancer Working Group
JCO Precis Oncol 2023 Jun;7:e2300039. doi: 10.1200/PO.23.00039. PMID: 37384868Free PMC Article
Aaroe A, Kurzrock R, Goyal G, Goodman AM, Patel H, Ruan G, Ulaner G, Young J, Li Z, Dustin D, Go RS, Diamond EL, Janku F
Blood Adv 2023 Aug 8;7(15):3984-3992. doi: 10.1182/bloodadvances.2022009013. PMID: 36857436Free PMC Article
Nowak JA
Surg Pathol Clin 2020 Sep;13(3):485-502. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.007. PMID: 32773196
Niemeyer CM
Haematologica 2014 Nov;99(11):1653-62. doi: 10.3324/haematol.2014.114595. PMID: 25420281Free PMC Article
Kirsammer G, Strizzi L, Margaryan NV, Gilgur A, Hyser M, Atkinson J, Kirschmann DA, Seftor EA, Hendrix MJ
Semin Cancer Biol 2014 Dec;29:40-50. Epub 2014 Jul 26 doi: 10.1016/j.semcancer.2014.07.007. PMID: 25073112Free PMC Article

Therapy

Piha-Paul SA, Tseng C, Tran HT, Gao M, Karp DD, Subbiah V, Tsimberidou AM, Kawedia JD, Fu S, Pant S, Yap TA, Morris VK, Kee BK, Blum Murphy M, Lim J, Meric-Bernstam F
Cancer Chemother Pharmacol 2023 Aug;92(2):107-118. Epub 2023 Jun 14 doi: 10.1007/s00280-023-04545-4. PMID: 37314501Free PMC Article
Aaroe A, Kurzrock R, Goyal G, Goodman AM, Patel H, Ruan G, Ulaner G, Young J, Li Z, Dustin D, Go RS, Diamond EL, Janku F
Blood Adv 2023 Aug 8;7(15):3984-3992. doi: 10.1182/bloodadvances.2022009013. PMID: 36857436Free PMC Article
Pasupuleti SK, Chao K, Ramdas B, Kanumuri R, Palam LR, Liu S, Wan J, Annesley C, Loh ML, Stieglitz E, Burke MJ, Kapur R
Mol Ther 2023 Apr 5;31(4):986-1001. Epub 2023 Feb 3 doi: 10.1016/j.ymthe.2023.01.030. PMID: 36739480Free PMC Article
Song Y, Zhao M, Zhang H, Yu B
Pharmacol Ther 2022 Feb;230:107966. Epub 2021 Aug 14 doi: 10.1016/j.pharmthera.2021.107966. PMID: 34403682
Zhao Y, Adjei AA
Nat Rev Clin Oncol 2014 Jul;11(7):385-400. Epub 2014 May 20 doi: 10.1038/nrclinonc.2014.83. PMID: 24840079

Prognosis

Wadensten E, Wessman S, Abel F, Diaz De Ståhl T, Tesi B, Orsmark Pietras C, Arvidsson L, Taylan F, Fransson S, Vogt H, Poluha A, Pradhananga S, Hellberg M, Lagerstedt-Robinson K, Raj Somarajan P, Samuelsson S, Orrsjö S, Maqbool K, Henning K, Strid T, Ek T, Fagman H, Olsson Bontell T, Martinsson T, Puls F, Kogner P, Wirta V, Pronk CJ, Wille J, Rosenquist R, Nistér M, Mertens F, Sabel M, Norén-Nyström U, Grillner P, Nordgren A, Ljungman G, Sandgren J, Gisselsson D; Genomic Medicine Sweden Childhood Cancer Working Group
JCO Precis Oncol 2023 Jun;7:e2300039. doi: 10.1200/PO.23.00039. PMID: 37384868Free PMC Article
Winer H, Rodrigues GOL, Hixon JA, Aiello FB, Hsu TC, Wachter BT, Li W, Durum SK
Cytokine 2022 Dec;160:156049. Epub 2022 Oct 3 doi: 10.1016/j.cyto.2022.156049. PMID: 36201890
Nowak JA
Surg Pathol Clin 2020 Sep;13(3):485-502. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.007. PMID: 32773196
Niemeyer CM
Haematologica 2014 Nov;99(11):1653-62. doi: 10.3324/haematol.2014.114595. PMID: 25420281Free PMC Article
Zhao Y, Adjei AA
Nat Rev Clin Oncol 2014 Jul;11(7):385-400. Epub 2014 May 20 doi: 10.1038/nrclinonc.2014.83. PMID: 24840079

Clinical prediction guides

Pasupuleti SK, Chao K, Ramdas B, Kanumuri R, Palam LR, Liu S, Wan J, Annesley C, Loh ML, Stieglitz E, Burke MJ, Kapur R
Mol Ther 2023 Apr 5;31(4):986-1001. Epub 2023 Feb 3 doi: 10.1016/j.ymthe.2023.01.030. PMID: 36739480Free PMC Article
Winer H, Rodrigues GOL, Hixon JA, Aiello FB, Hsu TC, Wachter BT, Li W, Durum SK
Cytokine 2022 Dec;160:156049. Epub 2022 Oct 3 doi: 10.1016/j.cyto.2022.156049. PMID: 36201890
Nowak JA
Surg Pathol Clin 2020 Sep;13(3):485-502. Epub 2020 Jul 11 doi: 10.1016/j.path.2020.05.007. PMID: 32773196
Zhao Y, Adjei AA
Nat Rev Clin Oncol 2014 Jul;11(7):385-400. Epub 2014 May 20 doi: 10.1038/nrclinonc.2014.83. PMID: 24840079
Gu Y, Nelson DL
Cytogenet Genome Res 2003;100(1-4):129-39. doi: 10.1159/000072847. PMID: 14526173

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