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Increased CD4:CD8 ratio

MedGen UID:
1614673
Concept ID:
C0920173
Finding
Synonyms: Increased CD4+/CD8+ ratio; Increased CD4+:CD8+ ratio
 
HPO: HP:0033221

Definition

An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CD4:CD8 ratio

Conditions with this feature

Autoimmune disease, multisystem, infantile-onset, 2
MedGen UID:
934735
Concept ID:
C4310768
Disease or Syndrome
Any autoimmune disease, multisystem, infantile-onset in which the cause of the disease is a mutation in the ZAP70 gene.
Proteasome-associated autoinflammatory syndrome 2
MedGen UID:
1648482
Concept ID:
C4747989
Disease or Syndrome
Proteasome-associated autoinflammatory syndrome-2 (PRAAS2) is an autosomal dominant disorder with onset in early infancy. Affected individuals develop severe inflammatory neutrophilic dermatitis, autoimmunity, and variable immunodeficiency (summary by Poli et al., 2018). For a discussion of genetic heterogeneity of PRAAS, see PRAAS1 (256040).

Professional guidelines

PubMed

Lv J, Qin M, Pang X, Chen L, Liao Y, Wang W, Liu Y, Li S, Wang Z, Wu W
Int J Biol Macromol 2024 Oct;278(Pt 1):134599. Epub 2024 Aug 8 doi: 10.1016/j.ijbiomac.2024.134599. PMID: 39127288
Zhong M, Li M, Qi M, Su Y, Yu N, Lv R, Ye Z, Zhang X, Xu X, Cheng C, Chen C, Wei H
Front Immunol 2022;13:1033098. Epub 2023 Jan 9 doi: 10.3389/fimmu.2022.1033098. PMID: 36700216Free PMC Article
Monsalvo M, Vallejo A, Fontecha M, Vivancos MJ, Vizcarra P, Casado JL
Int J STD AIDS 2019 Jun;30(7):656-662. Epub 2019 Apr 8 doi: 10.1177/0956462419834129. PMID: 30961467

Recent clinical studies

Etiology

Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH
J Acquir Immune Defic Syndr 2022 Jan 1;89(1):77-86. doi: 10.1097/QAI.0000000000002817. PMID: 34878437
Cui P, Li L, Zhang Y, Li Z
Allergol Immunopathol (Madr) 2022;50(1):60-67. Epub 2022 Jan 1 doi: 10.15586/aei.v50i1.498. PMID: 34873897
Li X, Xiao C, Qu K
Biosci Rep 2021 Mar 26;41(3) doi: 10.1042/BSR20204457. PMID: 33624761Free PMC Article
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Kovacikova L, Krasnanova V, Skrak P, Zahorec M, Kantorova A, Semberova J, Bacharova L
World J Pediatr Congenit Heart Surg 2017 Nov;8(6):672-682. doi: 10.1177/2150135117732529. PMID: 29187105

Diagnosis

Zahoor F, Junaid S, Afzal G
J Pak Med Assoc 2023 Nov;73(11):2260-2262. doi: 10.47391/JPMA.8348. PMID: 38013542
Crane JC, Gordon MJ, Basen-Engquist K, Ferrajoli A, Markofski MM, Lee CY, Fares S, Simpson RJ, LaVoy EC
Eur J Haematol 2023 Jun;110(6):732-742. Epub 2023 Mar 31 doi: 10.1111/ejh.13958. PMID: 36946440Free PMC Article
Wang B, He Z, Yu H, Ou Z, Chen J, Yang M, Fan X, Lin T, Huang J
Cancer Immunol Immunother 2022 Jun;71(6):1507-1517. Epub 2021 Oct 31 doi: 10.1007/s00262-021-03063-7. PMID: 34718847Free PMC Article
Miyoshi T, Otsuka F, Takeda M, Inagaki K, Otani H, Ogura T, Ichiki K, Amano T, Makino H
Endocr J 2007 Jun;54(3):425-30. Epub 2007 Apr 20 doi: 10.1507/endocrj.k06-161. PMID: 17446653
Yamauchi M, Inoue D, Fukunaga Y, Kakudo K, Koshiyama H
Thyroid 1997 Dec;7(6):901-3. doi: 10.1089/thy.1997.7.901. PMID: 9459635

Therapy

Muccini C, Gianotti N, Lolatto R, Nozza S, Diotallevi S, Castagna A
AIDS 2024 Nov 1;38(13):1890-1892. Epub 2024 Sep 26 doi: 10.1097/QAD.0000000000003984. PMID: 39325006
Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH
J Acquir Immune Defic Syndr 2022 Jan 1;89(1):77-86. doi: 10.1097/QAI.0000000000002817. PMID: 34878437
Li X, Xiao C, Qu K
Biosci Rep 2021 Mar 26;41(3) doi: 10.1042/BSR20204457. PMID: 33624761Free PMC Article
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Miyoshi T, Otsuka F, Takeda M, Inagaki K, Otani H, Ogura T, Ichiki K, Amano T, Makino H
Endocr J 2007 Jun;54(3):425-30. Epub 2007 Apr 20 doi: 10.1507/endocrj.k06-161. PMID: 17446653

Prognosis

Zhang H, Li Y, Liu YW, Liu YG, Chen X
Sci Rep 2024 Jun 4;14(1):12799. doi: 10.1038/s41598-024-61632-z. PMID: 38834662Free PMC Article
Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F, Luessi F
Mult Scler 2018 Apr;24(5):632-641. Epub 2017 Apr 24 doi: 10.1177/1352458517703799. PMID: 28436295
Montaudié H, Pradelli J, Passeron T, Lacour JP, Leroy S
Br J Dermatol 2017 Apr;176(4):1060-1063. Epub 2016 Dec 19 doi: 10.1111/bjd.14808. PMID: 27291635
Saber CN, Grønhøj Larsen C, Dalianis T, von Buchwald C
Oral Oncol 2016 Jul;58:8-13. Epub 2016 May 7 doi: 10.1016/j.oraloncology.2016.04.004. PMID: 27311396
Hu FJ, Ge MH, Li P, Wang CC, Ling YT, Mao WM, Ling ZQ
Clin Chim Acta 2012 Jan 18;413(1-2):213-8. Epub 2011 Sep 29 doi: 10.1016/j.cca.2011.09.026. PMID: 21983162

Clinical prediction guides

Muccini C, Gianotti N, Lolatto R, Nozza S, Diotallevi S, Castagna A
AIDS 2024 Nov 1;38(13):1890-1892. Epub 2024 Sep 26 doi: 10.1097/QAD.0000000000003984. PMID: 39325006
Meyer-Myklestad MH, Medhus AW, Stiksrud B, Lorvik KB, Seljeflot I, Hansen SH, Holm K, Hov JR, Kvale D, Dyrhol-Riise AM, Kummen M, Trøseid M, Reikvam DH
J Acquir Immune Defic Syndr 2022 Jan 1;89(1):77-86. doi: 10.1097/QAI.0000000000002817. PMID: 34878437
Torres B, Guardo AC, Squarcia M, Diaz A, Fabra A, Caballero M, Ugarte A, Leal L, Gatell JM, Plana M, Garcia F
HIV Med 2021 Sep;22(8):674-681. Epub 2021 Jul 20 doi: 10.1111/hiv.13114. PMID: 34288357
Zhabokritsky A, Szadkowski L, Cooper C, Loutfy M, Wong A, McClean A, Hogg RS, Walmsley SL; Canadian Observational Cohort (CANOC) Collaboration
J Antimicrob Chemother 2021 Feb 11;76(3):729-737. doi: 10.1093/jac/dkaa484. PMID: 33249444Free PMC Article
Rivera NV, Hagemann-Jensen M, Ferreira MAR, Kullberg S, Eklund A, Martin NG, Padyukov L, Grunewald J
Sci Rep 2017 Jul 17;7(1):5623. doi: 10.1038/s41598-017-05754-7. PMID: 28717140Free PMC Article

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