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Stillbirth

MedGen UID:
154536
•Concept ID:
C0595939
•
Finding
Synonym: Stillbirths
SNOMED CT: SB - Stillbirth (237364002); Stillbirth (237364002)
 
HPO: HP:0003826

Definition

Death of the fetus in utero after at least 22 weeks of gestation. [from HPO]

Professional guidelines

PubMed

Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction.
Stepan H, Galindo A, Hund M, Schlembach D, Sillman J, Surbek D, Vatish M
Ultrasound Obstet Gynecol 2023 Feb;61(2):168-180. doi: 10.1002/uog.26032. PMID: 35816445
Antepartum Fetal Surveillance: ACOG Practice Bulletin, Number 229.
Obstet Gynecol 2021 Jun 1;137(6):e116-e127. doi: 10.1097/AOG.0000000000004410. PMID: 34011889
FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal growth restriction.
Melamed N, Baschat A, Yinon Y, Athanasiadis A, Mecacci F, Figueras F, Berghella V, Nazareth A, Tahlak M, McIntyre HD, Da Silva Costa F, Kihara AB, Hadar E, McAuliffe F, Hanson M, Ma RC, Gooden R, Sheiner E, Kapur A, Divakar H, Ayres-de-Campos D, Hiersch L, Poon LC, Kingdom J, Romero R, Hod M
Int J Gynaecol Obstet 2021 Mar;152 Suppl 1(Suppl 1):3-57. doi: 10.1002/ijgo.13522. PMID: 33740264Free PMC Article

Recent clinical studies

Etiology

Adequacy of prenatal care and stillbirth.
Dayal S, Fogel J, Griggs R
Minerva Obstet Gynecol 2022 Feb;74(1):68-74. Epub 2021 Apr 20 doi: 10.23736/S2724-606X.21.04769-2. PMID: 33876906
Stillbirth: Evaluation and Follow-up.
Page JM, Silver RM
Obstet Gynecol Clin North Am 2020 Sep;47(3):439-451. doi: 10.1016/j.ogc.2020.04.008. PMID: 32762929
The psychological, social, and economic impact of stillbirth on families.
Murphy S, Cacciatore J
Semin Fetal Neonatal Med 2017 Jun;22(3):129-134. Epub 2017 Feb 14 doi: 10.1016/j.siny.2017.02.002. PMID: 28214156
Thrombophilias and stillbirth.
Werner EF, Lockwood CJ
Clin Obstet Gynecol 2010 Sep;53(3):617-27. doi: 10.1097/GRF.0b013e3181eb658c. PMID: 20661046
The epidemiology of stillbirth.
Cnattingius S, Stephansson O
Semin Perinatol 2002 Feb;26(1):25-30. doi: 10.1053/sper.2002.29841. PMID: 11876563

Diagnosis

Pregnancy complications and later life women's health.
McNestry C, Killeen SL, Crowley RK, McAuliffe FM
Acta Obstet Gynecol Scand 2023 May;102(5):523-531. Epub 2023 Feb 17 doi: 10.1111/aogs.14523. PMID: 36799269Free PMC Article
Monkeypox and pregnancy.
Carvajal A, Vigil-De Gracia P
Am J Obstet Gynecol MFM 2022 Nov;4(6):100746. Epub 2022 Sep 6 doi: 10.1016/j.ajogmf.2022.100746. PMID: 36084787Free PMC Article
Addressing preventable stillbirth and brain injury.
The Lancet
Lancet 2018 Nov 24;392(10161):2238. doi: 10.1016/S0140-6736(18)32972-6. PMID: 30496109
Complicated grief after perinatal loss.
Kersting A, Wagner B
Dialogues Clin Neurosci 2012 Jun;14(2):187-94. doi: 10.31887/DCNS.2012.14.2/akersting. PMID: 22754291Free PMC Article
Maternal medical disease and stillbirth.
Coletta J, Simpson LL
Clin Obstet Gynecol 2010 Sep;53(3):607-16. doi: 10.1097/GRF.0b013e3181eb2ca0. PMID: 20661045

Therapy

Late-Preterm Antenatal Steroids for Reduction of Neonatal Respiratory Complications: A Randomized Controlled Trial.
Yenuberi H, Ross B, Sasmita Tirkey R, Benjamin SJ, Rathore S, Karuppusami R, Lal A, Thomas N, Mathew JE
Obstet Gynecol 2024 Apr 1;143(4):468-474. Epub 2024 Feb 8 doi: 10.1097/AOG.0000000000005520. PMID: 38330411
Safety of Biologics for Atopic Diseases During Pregnancy.
Shakuntulla F, Chiarella SE
J Allergy Clin Immunol Pract 2022 Dec;10(12):3149-3155. Epub 2022 Aug 18 doi: 10.1016/j.jaip.2022.08.013. PMID: 35987486Free PMC Article
Prevention of preeclampsia with aspirin.
Rolnik DL, Nicolaides KH, Poon LC
Am J Obstet Gynecol 2022 Feb;226(2S):S1108-S1119. Epub 2020 Aug 21 doi: 10.1016/j.ajog.2020.08.045. PMID: 32835720
Ginger for nausea and vomiting of pregnancy.
Lindblad AJ, Koppula S
Can Fam Physician 2016 Feb;62(2):145. PMID: 26884528Free PMC Article
Complicated grief after perinatal loss.
Kersting A, Wagner B
Dialogues Clin Neurosci 2012 Jun;14(2):187-94. doi: 10.31887/DCNS.2012.14.2/akersting. PMID: 22754291Free PMC Article

Prognosis

Stillbirth: Evaluation and Follow-up.
Page JM, Silver RM
Obstet Gynecol Clin North Am 2020 Sep;47(3):439-451. doi: 10.1016/j.ogc.2020.04.008. PMID: 32762929
Injury-related maternal mortality.
Ray JG, Zipursky J, Park AL
Am J Obstet Gynecol 2018 Sep;219(3):307-308. Epub 2018 May 29 doi: 10.1016/j.ajog.2018.05.025. PMID: 29852158
Neuropathological protocol for the study of unexplained stillbirth.
Roncati L, Piscioli F, Pusiol T, Lavezzi AM
Folia Neuropathol 2017;55(2):79-85. doi: 10.5114/fn.2017.68576. PMID: 28677366
Survival of Infants Born at Periviable Gestational Ages.
Patel RM, Rysavy MA, Bell EF, Tyson JE
Clin Perinatol 2017 Jun;44(2):287-303. Epub 2017 Mar 22 doi: 10.1016/j.clp.2017.01.009. PMID: 28477661Free PMC Article
Diabetic-associated stillbirth: incidence, pathophysiology, and prevention.
Dudley DJ
Clin Perinatol 2007 Dec;34(4):611-26, vii. doi: 10.1016/j.clp.2007.09.003. PMID: 18063109

Clinical prediction guides

Risk prediction for stillbirth: Further to go.
Jardine J
BJOG 2023 Aug;130(9):1071. Epub 2023 Apr 11 doi: 10.1111/1471-0528.17469. PMID: 37430433
Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction.
Stepan H, Galindo A, Hund M, Schlembach D, Sillman J, Surbek D, Vatish M
Ultrasound Obstet Gynecol 2023 Feb;61(2):168-180. doi: 10.1002/uog.26032. PMID: 35816445
Clinical significance of cerebroplacental ratio.
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319
Opportunities and Challenges in Global Perinatal Research.
Duby J, Sharma R, Bhutta ZA
Neonatology 2018;114(2):93-102. Epub 2018 May 16 doi: 10.1159/000488310. PMID: 29768264
Usefulness of a biomarker to identify placental dysfunction in the context of malaria.
Gueneuc A, Deloron P, Bertin GI
Malar J 2017 Jan 3;16(1):11. doi: 10.1186/s12936-016-1664-0. PMID: 28049536Free PMC Article

Recent systematic reviews

Association of pre-/early pregnancy high blood pressure and pregnancy outcomes: a systemic review and meta-analysis.
Jin M, Liu X, Liu X, Wu Y, Zhang Y, Zhang L, Li Z, Ye R, Li N
J Matern Fetal Neonatal Med 2024 Dec;37(1):2296366. Epub 2023 Dec 27 doi: 10.1080/14767058.2023.2296366. PMID: 38151254
Deprived areas and adverse perinatal outcome: a systematic review.
Novillo-Del-Álamo B, Martínez-Varea A, Nieto-Tous M, Morales-Roselló J
Arch Gynecol Obstet 2024 Apr;309(4):1205-1218. Epub 2023 Dec 8 doi: 10.1007/s00404-023-07300-5. PMID: 38063892
A Systematic Review to Compare Adverse Pregnancy Outcomes in Women with Pregestational Diabetes and Gestational Diabetes.
Malaza N, Masete M, Adam S, Dias S, Nyawo T, Pheiffer C
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710846. PMID: 36078559Free PMC Article
Maternal and foetal-neonatal outcomes of dengue virus infection during pregnancy.
Rathore SS, Oberoi S, Hilliard J, Raja R, Ahmed NK, Vishwakarma Y, Iqbal K, Kumari C, Velasquez-Botero F, Nieto-Salazar MA, Cortes GAM, Akomaning E, Musa IEM
Trop Med Int Health 2022 Jul;27(7):619-629. Epub 2022 Jun 11 doi: 10.1111/tmi.13783. PMID: 35689528
Maternal and perinatal complications according to maternal age: A systematic review and meta-analysis.
Saccone G, Gragnano E, Ilardi B, Marrone V, Strina I, Venturella R, Berghella V, Zullo F
Int J Gynaecol Obstet 2022 Oct;159(1):43-55. Epub 2022 Feb 7 doi: 10.1002/ijgo.14100. PMID: 35044694Free PMC Article

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