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Cardiomegaly due to hypertension

MedGen UID:
151958
•Concept ID:
C0694541
•
Disease or Syndrome
Synonyms: Hypertensive cardiomegaly; Hypertensive Cardiomegaly
SNOMED CT: Cardiomegaly due to hypertension (275516004); Hypertensive cardiomegaly (275516004)

Definition

Abnormal enlargement of the heart resulting from long-standing hypertension. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiomegaly due to hypertension

Professional guidelines

PubMed

Efficacy of echocardiography for differential diagnosis of left ventricular hypertrophy: special focus on speckle-tracking longitudinal strain.
Tanaka H
J Echocardiogr 2021 Jun;19(2):71-79. Epub 2021 Jan 18 doi: 10.1007/s12574-020-00508-3. PMID: 33460030Free PMC Article
Hypertension Canada's 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children.
Rabi DM, McBrien KA, Sapir-Pichhadze R, Nakhla M, Ahmed SB, Dumanski SM, Butalia S, Leung AA, Harris KC, Cloutier L, Zarnke KB, Ruzicka M, Hiremath S, Feldman RD, Tobe SW, Campbell TS, Bacon SL, Nerenberg KA, Dresser GK, Fournier A, Burgess E, Lindsay P, Rabkin SW, Prebtani APH, Grover S, Honos G, Alfonsi JE, Arcand J, Audibert F, Benoit G, Bittman J, Bolli P, Côté AM, Dionne J, Don-Wauchope A, Edwards C, Firoz T, Gabor JY, Gilbert RE, Grégoire JC, Gryn SE, Gupta M, Hannah-Shmouni F, Hegele RA, Herman RJ, Hill MD, Howlett JG, Hundemer GL, Jones C, Kaczorowski J, Khan NA, Kuyper LM, Lamarre-Cliche M, Lavoie KL, Leiter LA, Lewanczuk R, Logan AG, Magee LA, Mangat BK, McFarlane PA, McLean D, Michaud A, Milot A, Moe GW, Penner SB, Pipe A, Poppe AY, Rey E, Roerecke M, Schiffrin EL, Selby P, Sharma M, Shoamanesh A, Sivapalan P, Townsend RR, Tran K, Trudeau L, Tsuyuki RT, Vallée M, Woo V, Bell AD, Daskalopoulou SS
Can J Cardiol 2020 May;36(5):596-624. doi: 10.1016/j.cjca.2020.02.086. PMID: 32389335
Electrocardiographic criteria of left ventricular hypertrophy in patients with morbid obesity.
Domienik-Karłowicz J, Lichodziejewska B, Lisik W, Ciurzyński M, Bienias P, Chmura A, Pruszczyk P
Ann Noninvasive Electrocardiol 2011 Jul;16(3):258-62. doi: 10.1111/j.1542-474X.2011.00440.x. PMID: 21762253Free PMC Article

Recent clinical studies

Etiology

Hyperhomocysteinemia Promotes Cardiac Hypertrophy in Hypertension.
Deng Y, Li Z, An X, Fan R, Wang Y, Li J, Yang X, Liao J, Xia Y
Oxid Med Cell Longev 2022;2022:1486157. Epub 2022 Aug 22 doi: 10.1155/2022/1486157. PMID: 36046692Free PMC Article
Basal Ventricular Septal Hypertrophy in Systemic Hypertension.
Loncaric F, Nunno L, Mimbrero M, Marciniak M, Fernandes JF, Tirapu L, Fabijanovic D, Sanchis L, Doltra A, Cikes M, Lamata P, Bijnens B, Sitges M
Am J Cardiol 2020 May 1;125(9):1339-1346. Epub 2020 Feb 8 doi: 10.1016/j.amjcard.2020.01.045. PMID: 32164912
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Cardiac hypertrophy and failure in hypertension.
Johnson DB, Dell'Italia LJ
Curr Opin Nephrol Hypertens 1996 Mar;5(2):186-91. doi: 10.1097/00041552-199603000-00016. PMID: 8744544
Dippers versus non-dippers.
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037

Diagnosis

Phenotyping the hypertensive heart.
Tadic M, Cuspidi C, Marwick TH
Eur Heart J 2022 Oct 11;43(38):3794-3810. doi: 10.1093/eurheartj/ehac393. PMID: 35869979
Estrogen-related mechanisms in sex differences of hypertension and target organ damage.
Sabbatini AR, Kararigas G
Biol Sex Differ 2020 Jun 1;11(1):31. doi: 10.1186/s13293-020-00306-7. PMID: 32487164Free PMC Article
Personality traits and hypertension-mediated organ damage.
Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791

Therapy

Sex, gender, and subclinical hypertensiveorgan damage-heart.
Cuspidi C, Gherbesi E, Sala C, Tadic M
J Hum Hypertens 2023 Aug;37(8):626-633. Epub 2022 Aug 27 doi: 10.1038/s41371-022-00750-5. PMID: 36030347
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Changes in left ventricular geometry during antihypertensive treatment.
Salvetti M, Paini A, Bertacchini F, Stassaldi D, Aggiusti C, Agabiti Rosei C, Bassetti D, Agabiti-Rosei E, Muiesan ML
Pharmacol Res 2018 Aug;134:193-199. Epub 2018 Jun 26 doi: 10.1016/j.phrs.2018.06.026. PMID: 29959031
Beta-blockers and heart failure.
Cruickshank JM
Indian Heart J 2010 Mar-Apr;62(2):101-10. PMID: 21180298
Cardiac remodeling in systemic hypertension.
Kenchaiah S, Pfeffer MA
Med Clin North Am 2004 Jan;88(1):115-30. doi: 10.1016/s0025-7125(03)00168-8. PMID: 14871054

Prognosis

Personality traits and hypertension-mediated organ damage.
Popiołek L, Siga O, Dzieża-Grudnik A, Popiołek I, Moląg M, Królczyk J, Grodzicki T, Walczewska J, Rutkowski K
Psychiatr Pol 2019 Oct 30;53(5):1003-1020. doi: 10.12740/PP/108453. PMID: 31955182
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Obesity and left ventricular hypertrophy: the hypertension connection.
Woodiwiss AJ, Norton GR
Curr Hypertens Rep 2015 Apr;17(4):539. doi: 10.1007/s11906-015-0539-z. PMID: 25794954
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Dippers versus non-dippers.
Verdecchia P, Schillaci G, Porcellati C
J Hypertens Suppl 1991 Dec;9(8):S42-4. PMID: 1839037

Clinical prediction guides

Morphological and functional cardiac consequences of rapid hypertension treatment: a cohort study.
Jordan AN, Fulford J, Gooding K, Anning C, Wilkes L, Ball C, Pamphilon N, Mawson D, Clark CE, Shore AC, Sharp ASP, Bellenger NG
J Cardiovasc Magn Reson 2021 Oct 25;23(1):122. doi: 10.1186/s12968-021-00805-5. PMID: 34689818Free PMC Article
MRI and Neuropsychological Correlates in African Americans With Hypertension and Left Ventricular Hypertrophy.
Waldron-Perrine B, Kisser JE, Brody A, Haacke EM, Dawood R, Millis S, Levy P
Am J Hypertens 2018 Jul 16;31(8):865-868. doi: 10.1093/ajh/hpy060. PMID: 29672672Free PMC Article
Hypertension, left ventricular hypertrophy, and sudden cardiac death.
Shenasa M, Shenasa H
Int J Cardiol 2017 Jun 15;237:60-63. Epub 2017 Mar 3 doi: 10.1016/j.ijcard.2017.03.002. PMID: 28285801
Myocardial remodeling in hypertension.
Nadruz W
J Hum Hypertens 2015 Jan;29(1):1-6. Epub 2014 May 8 doi: 10.1038/jhh.2014.36. PMID: 24804791
Adrenergic activity and myocardial anatomy and function in essential hypertension.
Muiesan G, Agabiti-Rosei E, Muiesan ML
J Hypertens Suppl 1985 Dec;3(4):S45-50. PMID: 3007705

Recent systematic reviews

COVID-19 Infection and Myocarditis: A State-of-the-Art Systematic Review.
Jaiswal V, Sarfraz Z, Sarfraz A, Mukherjee D, Batra N, Hitawala G, Yaqoob S, Patel A, Agarwala P, Ruchika, Sarfraz M, Bano S, Azeem N, Naz S, Jaiswal A, Sharma P, Chaudhary G
J Prim Care Community Health 2021 Jan-Dec;12:21501327211056800. doi: 10.1177/21501327211056800. PMID: 34854348Free PMC Article
Pharmacotherapy for hypertension-induced left ventricular hypertrophy.
Leache L, Gutiérrez-Valencia M, Finizola RM, Infante E, Finizola B, Pardo Pardo J, Flores Y, Granero R, Arai KJ
Cochrane Database Syst Rev 2021 Oct 10;10(10):CD012039. doi: 10.1002/14651858.CD012039.pub3. PMID: 34628642Free PMC Article
Exercise blood pressure and cardiac structure: A systematic review and meta-analysis of cross-sectional studies.
Moore MN, Climie RE, Otahal P, Sharman JE, Schultz MG
J Sci Med Sport 2021 Sep;24(9):925-930. Epub 2021 Mar 2 doi: 10.1016/j.jsams.2021.02.014. PMID: 33707155
Left ventricular hypertrophy and cognitive function: a systematic review.
Restrepo C, Patel SK, Rethnam V, Werden E, Ramchand J, Churilov L, Burrell LM, Brodtmann A
J Hum Hypertens 2018 Mar;32(3):171-179. Epub 2018 Jan 12 doi: 10.1038/s41371-017-0023-0. PMID: 29330420
Left-ventricular hypertrophy and obesity: a systematic review and meta-analysis of echocardiographic studies.
Cuspidi C, Rescaldani M, Sala C, Grassi G
J Hypertens 2014 Jan;32(1):16-25. doi: 10.1097/HJH.0b013e328364fb58. PMID: 24309485

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