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Altered Level of Consciousness

MedGen UID:
148225
•Concept ID:
C0751054
•
Finding
Synonym: Consciousness, Level Altered

Definition

A level of awareness and arousal other than normal. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAltered Level of Consciousness

Professional guidelines

PubMed

EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical practice guidelines panel, Wendon, J; Panel members, Cordoba J, Dhawan A, Larsen FS, Manns M, Samuel D, Simpson KJ, Yaron I; EASL Governing Board representative, Bernardi M
J Hepatol 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003. PMID: 28417882
Altered Level Of Consciousness: Evidence-Based Management In The Emergency Department.
Song JL, Wang VJ
Pediatr Emerg Med Pract 2017 Jan;14(1):1-28. Epub 2017 Jan 2 PMID: 28027458
Pharmacological and nonpharmacological management of delirium in critically ill patients.
Hipp DM, Ely EW
Neurotherapeutics 2012 Jan;9(1):158-75. doi: 10.1007/s13311-011-0102-9. PMID: 22270810Free PMC Article

Recent clinical studies

Etiology

The inter-relationship between delirium and dementia: the importance of delirium prevention.
Fong TG, Inouye SK
Nat Rev Neurol 2022 Oct;18(10):579-596. Epub 2022 Aug 26 doi: 10.1038/s41582-022-00698-7. PMID: 36028563Free PMC Article
Etiologies of altered level of consciousness in the emergency room.
Kim KT, Jeon JC, Jung CG, Park JA, Seo JG, Kwon DH
Sci Rep 2022 Mar 23;12(1):4972. doi: 10.1038/s41598-022-09110-2. PMID: 35322140Free PMC Article
Spinal injuries.
Mackenzie R
J R Army Med Corps 2002 Jun;148(2):163-71. doi: 10.1136/jramc-148-02-11. PMID: 12174560
Intensive Care Delirium Screening Checklist: evaluation of a new screening tool.
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y
Intensive Care Med 2001 May;27(5):859-64. doi: 10.1007/s001340100909. PMID: 11430542
Clarifying confusion: the confusion assessment method. A new method for detection of delirium.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI
Ann Intern Med 1990 Dec 15;113(12):941-8. doi: 10.7326/0003-4819-113-12-941. PMID: 2240918

Diagnosis

Diagnostic and therapeutic approach to adult central nervous system vasculitis.
Nehme A, Boulanger M, Aouba A, Pagnoux C, Zuber M, Touzé E, de Boysson H
Rev Neurol (Paris) 2022 Dec;178(10):1041-1054. Epub 2022 Sep 22 doi: 10.1016/j.neurol.2022.05.003. PMID: 36156251
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical practice guidelines panel, Wendon, J; Panel members, Cordoba J, Dhawan A, Larsen FS, Manns M, Samuel D, Simpson KJ, Yaron I; EASL Governing Board representative, Bernardi M
J Hepatol 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003. PMID: 28417882
Bacterial meningitis.
Heckenberg SG, Brouwer MC, van de Beek D
Handb Clin Neurol 2014;121:1361-75. doi: 10.1016/B978-0-7020-4088-7.00093-6. PMID: 24365425
Intensive Care Delirium Screening Checklist: evaluation of a new screening tool.
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y
Intensive Care Med 2001 May;27(5):859-64. doi: 10.1007/s001340100909. PMID: 11430542
Clarifying confusion: the confusion assessment method. A new method for detection of delirium.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI
Ann Intern Med 1990 Dec 15;113(12):941-8. doi: 10.7326/0003-4819-113-12-941. PMID: 2240918

Therapy

Cerebral venous thrombosis: a practical review.
Borhani-Haghighi A, Hooshmandi E
Postgrad Med J 2024 Jan 21;100(1180):68-83. doi: 10.1093/postmj/qgad103. PMID: 37978050
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical practice guidelines panel, Wendon, J; Panel members, Cordoba J, Dhawan A, Larsen FS, Manns M, Samuel D, Simpson KJ, Yaron I; EASL Governing Board representative, Bernardi M
J Hepatol 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003. PMID: 28417882
Bacterial meningitis.
Heckenberg SG, Brouwer MC, van de Beek D
Handb Clin Neurol 2014;121:1361-75. doi: 10.1016/B978-0-7020-4088-7.00093-6. PMID: 24365425
Bacterial meningitis.
Roos KL, van de Beek D
Handb Clin Neurol 2010;96:51-63. Epub 2010 Jan 19 doi: 10.1016/S0072-9752(09)96004-3. PMID: 20109674
Whipple disease.
Louis ED
Curr Neurol Neurosci Rep 2003 Nov;3(6):470-5. doi: 10.1007/s11910-003-0049-2. PMID: 14565900

Prognosis

The inter-relationship between delirium and dementia: the importance of delirium prevention.
Fong TG, Inouye SK
Nat Rev Neurol 2022 Oct;18(10):579-596. Epub 2022 Aug 26 doi: 10.1038/s41582-022-00698-7. PMID: 36028563Free PMC Article
EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical practice guidelines panel, Wendon, J; Panel members, Cordoba J, Dhawan A, Larsen FS, Manns M, Samuel D, Simpson KJ, Yaron I; EASL Governing Board representative, Bernardi M
J Hepatol 2017 May;66(5):1047-1081. doi: 10.1016/j.jhep.2016.12.003. PMID: 28417882
Bacterial meningitis.
Roos KL, van de Beek D
Handb Clin Neurol 2010;96:51-63. Epub 2010 Jan 19 doi: 10.1016/S0072-9752(09)96004-3. PMID: 20109674
Intensive Care Delirium Screening Checklist: evaluation of a new screening tool.
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y
Intensive Care Med 2001 May;27(5):859-64. doi: 10.1007/s001340100909. PMID: 11430542
Clarifying confusion: the confusion assessment method. A new method for detection of delirium.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI
Ann Intern Med 1990 Dec 15;113(12):941-8. doi: 10.7326/0003-4819-113-12-941. PMID: 2240918

Clinical prediction guides

EEG Findings in Coronavirus Disease.
Pilato MS, Urban A, Alkawadri R, Barot NV, Castellano JF, Rajasekaran V, Bagić AI, Fong-Isariyawongse JS
J Clin Neurophysiol 2022 Feb 1;39(2):159-165. doi: 10.1097/WNP.0000000000000752. PMID: 32639251
Neuroinflammation in sepsis: sepsis associated delirium.
Piva S, McCreadie VA, Latronico N
Cardiovasc Hematol Disord Drug Targets 2015;15(1):10-8. doi: 10.2174/1871529x15666150108112452. PMID: 25567339
Bacterial meningitis.
Roos KL, van de Beek D
Handb Clin Neurol 2010;96:51-63. Epub 2010 Jan 19 doi: 10.1016/S0072-9752(09)96004-3. PMID: 20109674
Intensive Care Delirium Screening Checklist: evaluation of a new screening tool.
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y
Intensive Care Med 2001 May;27(5):859-64. doi: 10.1007/s001340100909. PMID: 11430542
Clarifying confusion: the confusion assessment method. A new method for detection of delirium.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI
Ann Intern Med 1990 Dec 15;113(12):941-8. doi: 10.7326/0003-4819-113-12-941. PMID: 2240918

Recent systematic reviews

Cervical spine injuries in adults ≥ 65 years after low-level falls - A systematic review and meta-analysis.
McCallum J, Eagles D, Ouyang Y, Ende JV, Vaillancourt C, Fehlmann C, Shorr R, Taljaard M, Stiell I
Am J Emerg Med 2023 May;67:144-155. Epub 2023 Feb 10 doi: 10.1016/j.ajem.2023.02.008. PMID: 36893628
Neurotoxicity associated with acyclovir and valacyclovir: A systematic review of cases.
Brandariz-Nuñez D, Correas-Sanahuja M, Maya-Gallego S, Martín Herranz I
J Clin Pharm Ther 2021 Aug;46(4):918-926. Epub 2021 Jun 19 doi: 10.1111/jcpt.13464. PMID: 34146428
How do neurologists diagnose transient ischemic attack: A systematic review.
Fitzpatrick T, Gocan S, Wang CQ, Hamel C, Bourgoin A, Dowlatshahi D, Stotts G, Shamy M
Int J Stroke 2019 Feb;14(2):115-124. Epub 2018 Dec 3 doi: 10.1177/1747493018816430. PMID: 30507363Free PMC Article
Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review.
Clericetti CM, Milani GP, Lava SAG, Bianchetti MG, Simonetti GD, Giannini O
Pediatr Nephrol 2018 Mar;33(3):485-491. Epub 2017 Nov 13 doi: 10.1007/s00467-017-3829-7. PMID: 29134448
Nervous system dysfunction in Henoch-Schonlein syndrome: systematic review of the literature.
Garzoni L, Vanoni F, Rizzi M, Simonetti GD, Goeggel Simonetti B, Ramelli GP, Bianchetti MG
Rheumatology (Oxford) 2009 Dec;48(12):1524-9. Epub 2009 Sep 21 doi: 10.1093/rheumatology/kep282. PMID: 19797041

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    Practice guidelines

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