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Metastatic Malignant Neoplasm in the Brain Stem

MedGen UID:
146354
•Concept ID:
C0686402
•
Neoplastic Process
Synonyms: Metastatic malignant neoplasm of brain stem; Metastatic malignant neoplasm to brain stem; Metastatic Malignant Neoplasm to the Brain Stem; Metastatic Neoplasm to the Brain Stem; Metastatic Neoplasm to the Brainstem; Metastatic Tumor to the Brain Stem; Metastatic Tumor to the Brainstem; Secondary malignant neoplasm of brain stem
SNOMED CT: Secondary malignant neoplasm of brain stem (94224009); Metastatic malignant neoplasm to brain stem (94224009); Metastatic malignant neoplasm of brain stem (94224009)

Definition

A malignant neoplasm that has spread from its original site of growth to the brain stem. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Brain Stem

Professional guidelines

PubMed

Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis.
Biermann J, Melms JC, Amin AD, Wang Y, Caprio LA, Karz A, Tagore S, Barrera I, Ibarra-Arellano MA, Andreatta M, Fullerton BT, Gretarsson KH, Sahu V, Mangipudy VS, Nguyen TTT, Nair A, Rogava M, Ho P, Koch PD, Banu M, Humala N, Mahajan A, Walsh ZH, Shah SB, Vaccaro DH, Caldwell B, Mu M, Wünnemann F, Chazotte M, Berhe S, Luoma AM, Driver J, Ingham M, Khan SA, Rapisuwon S, Slingluff CL Jr, Eigentler T, Röcken M, Carvajal R, Atkins MB, Davies MA, Agustinus A, Bakhoum SF, Azizi E, Siegelin M, Lu C, Carmona SJ, Hibshoosh H, Ribas A, Canoll P, Bruce JN, Bi WL, Agrawal P, Schapiro D, Hernando E, Macosko EZ, Chen F, Schwartz GK, Izar B
Cell 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007. PMID: 35803246Free PMC Article
Consensus guidelines for the use and interpretation of angiogenesis assays.
Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW
Angiogenesis 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. PMID: 29766399Free PMC Article

Recent clinical studies

Etiology

Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma.
Li G, Wang D, Zhai Y, Pan C, Zhang J, Wang C, Huang R, Yu M, Li Y, Liu X, Liu Y, Wu F, Zhao Z, Hu H, Shi Z, Kahlert UD, Jiang T, Zhang W
Cell Metab 2024 Aug 6;36(8):1696-1710.e10. doi: 10.1016/j.cmet.2024.07.011. PMID: 39111285
Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid.
Afflerbach AK, Rohrandt C, Brändl B, Sönksen M, Hench J, Frank S, Börnigen D, Alawi M, Mynarek M, Winkler B, Ricklefs F, Synowitz M, Dührsen L, Rutkowski S, Wefers AK, Müller FJ, Schoof M, Schüller U
Clin Chem 2024 Jan 4;70(1):250-260. doi: 10.1093/clinchem/hvad115. PMID: 37624932
Identification of a novel cuproptosis-related gene signature and integrative analyses in patients with lower-grade gliomas.
Bao JH, Lu WC, Duan H, Ye YQ, Li JB, Liao WT, Li YC, Sun YP
Front Immunol 2022;13:933973. Epub 2022 Aug 15 doi: 10.3389/fimmu.2022.933973. PMID: 36045691Free PMC Article
Molecular targeted therapy of glioblastoma.
Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790

Diagnosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.
Salles D, Laviola G, Malinverni ACM, Stávale JN
J Child Neurol 2020 Oct;35(12):852-858. Epub 2020 Jul 20 doi: 10.1177/0883073820937225. PMID: 32691644
Brain malignancies: Glioblastoma and brain metastases.
Lah TT, Novak M, Breznik B
Semin Cancer Biol 2020 Feb;60:262-273. Epub 2019 Oct 22 doi: 10.1016/j.semcancer.2019.10.010. PMID: 31654711
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580
Glioblastoma multiforme: Pathogenesis and treatment.
Alifieris C, Trafalis DT
Pharmacol Ther 2015 Aug;152:63-82. Epub 2015 May 2 doi: 10.1016/j.pharmthera.2015.05.005. PMID: 25944528

Therapy

Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma.
Ahir BK, Engelhard HH, Lakka SS
Mol Neurobiol 2020 May;57(5):2461-2478. Epub 2020 Mar 9 doi: 10.1007/s12035-020-01892-8. PMID: 32152825Free PMC Article
Molecular targeted therapy of glioblastoma.
Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, Reifenberger G, Weller M
Cancer Treat Rev 2019 Nov;80:101896. Epub 2019 Sep 11 doi: 10.1016/j.ctrv.2019.101896. PMID: 31541850
Glioblastoma multiforme: Pathogenesis and treatment.
Alifieris C, Trafalis DT
Pharmacol Ther 2015 Aug;152:63-82. Epub 2015 May 2 doi: 10.1016/j.pharmthera.2015.05.005. PMID: 25944528

Prognosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma.
Yang E, Wang L, Jin W, Liu X, Wang Q, Wu Y, Tan Y, Wang Y, Cui X, Zhao J, Tong F, Hong B, Xiao M, Liu X, Fang C, Kang C
Theranostics 2022;12(9):4330-4347. Epub 2022 May 16 doi: 10.7150/thno.71763. PMID: 35673568Free PMC Article
Cancer Stem Cells: Significance in Origin, Pathogenesis and Treatment of Glioblastoma.
Biserova K, Jakovlevs A, Uljanovs R, Strumfa I
Cells 2021 Mar 11;10(3) doi: 10.3390/cells10030621. PMID: 33799798Free PMC Article
Synaptic proximity enables NMDAR signalling to promote brain metastasis.
Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD, Galván JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D
Nature 2019 Sep;573(7775):526-531. Epub 2019 Sep 18 doi: 10.1038/s41586-019-1576-6. PMID: 31534217Free PMC Article
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Clinical prediction guides

Glioblastoma and Other Primary Brain Malignancies in Adults: A Review.
Schaff LR, Mellinghoff IK
JAMA 2023 Feb 21;329(7):574-587. doi: 10.1001/jama.2023.0023. PMID: 36809318Free PMC Article
Pilocytic Astrocytoma: A Review of General, Clinical, and Molecular Characteristics.
Salles D, Laviola G, Malinverni ACM, Stávale JN
J Child Neurol 2020 Oct;35(12):852-858. Epub 2020 Jul 20 doi: 10.1177/0883073820937225. PMID: 32691644
The Glioma Stem Cell Model in the Era of Single-Cell Genomics.
Suvà ML, Tirosh I
Cancer Cell 2020 May 11;37(5):630-636. doi: 10.1016/j.ccell.2020.04.001. PMID: 32396858
MGMT Status as a Clinical Biomarker in Glioblastoma.
Butler M, Pongor L, Su YT, Xi L, Raffeld M, Quezado M, Trepel J, Aldape K, Pommier Y, Wu J
Trends Cancer 2020 May;6(5):380-391. Epub 2020 Mar 27 doi: 10.1016/j.trecan.2020.02.010. PMID: 32348734Free PMC Article
A comprehensive profile of recurrent glioblastoma.
Campos B, Olsen LR, Urup T, Poulsen HS
Oncogene 2016 Nov 10;35(45):5819-5825. Epub 2016 Apr 4 doi: 10.1038/onc.2016.85. PMID: 27041580

Recent systematic reviews

Surgical Management of Adult Brainstem Gliomas: A Systematic Review and Meta-Analysis.
Ius T, Lombardi G, Baiano C, Berardinelli J, Romano A, Montemurro N, Cavallo LM, Pasqualetti F, Feletti A
Curr Oncol 2023 Nov 7;30(11):9772-9785. doi: 10.3390/curroncol30110709. PMID: 37999129Free PMC Article
MicroRNA delivery systems in glioma therapy and perspectives: A systematic review.
Jiménez-Morales JM, Hernández-Cuenca YE, Reyes-Abrahantes A, Ruiz-García H, Barajas-Olmos F, García-Ortiz H, Orozco L, Quiñones-Hinojosa A, Reyes-González J, Abrahantes-Pérez MDC
J Control Release 2022 Sep;349:712-730. Epub 2022 Jul 30 doi: 10.1016/j.jconrel.2022.07.027. PMID: 35905783
State of the Art in Combination Immuno/Radiotherapy for Brain Metastases: Systematic Review and Meta-Analysis.
Najafi M, Jahanbakhshi A, Gomar M, Iotti C, Giaccherini L, Rezaie O, Cavallieri F, Deantonio L, Bardoscia L, Botti A, Sardaro A, Cozzi S, Ciammella P
Curr Oncol 2022 Apr 22;29(5):2995-3012. doi: 10.3390/curroncol29050244. PMID: 35621634Free PMC Article
Childhood Brain Tumors: a Systematic Review of the Structural Neuroimaging Literature.
Ailion AS, Hortman K, King TZ
Neuropsychol Rev 2017 Sep;27(3):220-244. Epub 2017 Jun 23 doi: 10.1007/s11065-017-9352-6. PMID: 28646252
Challenges and opportunities in primary CNS lymphoma: A systematic review.
Kerbauy MN, Moraes FY, Lok BH, Ma J, Kerbauy LN, Spratt DE, Santos FP, Perini GF, Berlin A, Chung C, Hamerschlak N, Yahalom J
Radiother Oncol 2017 Mar;122(3):352-361. Epub 2017 Jan 16 doi: 10.1016/j.radonc.2016.12.033. PMID: 28104300

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