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Oral Cavity Submucous Fibrosis

MedGen UID:
14501
•Concept ID:
C0029171
•
Disease or Syndrome

Definition

Chronic, progressive, debilitating and non-reversible fibrosis of the submucosal tissues of the mouth. It is associated with chewing betel quid, a habit practiced in Southeast Asia and India. It is a precancerous condition and results in rigidity of the jaws and inability of the affected individual to open the mouth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOral Cavity Submucous Fibrosis

Professional guidelines

PubMed

Drug treatment for oral submucous fibrosis: an update.
Chen X, Xie H, Guo J
BMC Oral Health 2023 Oct 12;23(1):748. doi: 10.1186/s12903-023-03488-9. PMID: 37828490Free PMC Article
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993

Recent clinical studies

Etiology

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments.
Shen YW, Shih YH, Fuh LJ, Shieh TM
Int J Mol Sci 2020 Sep 30;21(19) doi: 10.3390/ijms21197231. PMID: 33008091Free PMC Article
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Clinical features and presentation of oral potentially malignant disorders.
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799

Diagnosis

Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.
Shih YH, Wang TH, Shieh TM, Tseng YH
Int J Mol Sci 2019 Jun 16;20(12) doi: 10.3390/ijms20122940. PMID: 31208114Free PMC Article
Clinical features and presentation of oral potentially malignant disorders.
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Nomenclature and classification of potentially malignant disorders of the oral mucosa.
Warnakulasuriya S, Johnson NW, van der Waal I
J Oral Pathol Med 2007 Nov;36(10):575-80. doi: 10.1111/j.1600-0714.2007.00582.x. PMID: 17944749

Therapy

Areca Nut and Oral Cancer: Evidence from Studies Conducted in Humans.
Warnakulasuriya S, Chen THH
J Dent Res 2022 Sep;101(10):1139-1146. Epub 2022 Apr 22 doi: 10.1177/00220345221092751. PMID: 35459408Free PMC Article
Oral Submucous Fibrosis: A Review on Biomarkers, Pathogenic Mechanisms, and Treatments.
Shen YW, Shih YH, Fuh LJ, Shieh TM
Int J Mol Sci 2020 Sep 30;21(19) doi: 10.3390/ijms21197231. PMID: 33008091Free PMC Article
Oral health consequences of smokeless tobacco use.
Muthukrishnan A, Warnakulasuriya S
Indian J Med Res 2018 Jul;148(1):35-40. doi: 10.4103/ijmr.IJMR_1793_17. PMID: 30264752Free PMC Article
Clinical features and presentation of oral potentially malignant disorders.
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Oral potentially malignant disorders: risk of progression to malignancy.
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

Prognosis

Single-cell transcriptomic analysis of gingivo-buccal oral cancer reveals two dominant cellular programs.
Kurkalang S, Roy S, Acharya A, Mazumder P, Mazumder S, Patra S, Ghosh S, Sarkar S, Kundu S, Biswas NK, Ghose S, Majumder PP, Maitra A
Cancer Sci 2023 Dec;114(12):4732-4746. Epub 2023 Oct 4 doi: 10.1111/cas.15979. PMID: 37792582Free PMC Article
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Clinical features and presentation of oral potentially malignant disorders.
Warnakulasuriya S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):582-590. Epub 2018 Apr 4 doi: 10.1016/j.oooo.2018.03.011. PMID: 29673799
Oral potentially malignant disorders: risk of progression to malignancy.
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319
Oral submucous fibrosis.
Paissat DK
Int J Oral Surg 1981 Oct;10(5):307-12. doi: 10.1016/s0300-9785(81)80026-9. PMID: 6807916

Clinical prediction guides

Interventions for managing oral submucous fibrosis.
Jones A, Veale B, Li T, Aggarwal VR, Twigg J
Cochrane Database Syst Rev 2024 Feb 28;2(2):CD007156. doi: 10.1002/14651858.CD007156.pub3. PMID: 38415846Free PMC Article
Single-cell transcriptomic analysis of gingivo-buccal oral cancer reveals two dominant cellular programs.
Kurkalang S, Roy S, Acharya A, Mazumder P, Mazumder S, Patra S, Ghosh S, Sarkar S, Kundu S, Biswas NK, Ghose S, Majumder PP, Maitra A
Cancer Sci 2023 Dec;114(12):4732-4746. Epub 2023 Oct 4 doi: 10.1111/cas.15979. PMID: 37792582Free PMC Article
Management of oral potentially malignant disorders.
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.
Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293
Oral potentially malignant disorders: risk of progression to malignancy.
Speight PM, Khurram SA, Kujan O
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):612-627. Epub 2017 Dec 29 doi: 10.1016/j.oooo.2017.12.011. PMID: 29396319

Recent systematic reviews

Interventions for managing oral submucous fibrosis.
Jones A, Veale B, Li T, Aggarwal VR, Twigg J
Cochrane Database Syst Rev 2024 Feb 28;2(2):CD007156. doi: 10.1002/14651858.CD007156.pub3. PMID: 38415846Free PMC Article
Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis.
Ramos-Garcia P, Roca-Rodriguez MDM, Aguilar-Diosdado M, Gonzalez-Moles MA
Oral Dis 2021 Apr;27(3):404-421. Epub 2020 Feb 18 doi: 10.1111/odi.13289. PMID: 31994293
Oral potentially malignant disorders: A comprehensive review on clinical aspects and management.
Warnakulasuriya S
Oral Oncol 2020 Mar;102:104550. Epub 2020 Jan 22 doi: 10.1016/j.oraloncology.2019.104550. PMID: 31981993
Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype.
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis.
Mello FW, Miguel AFP, Dutra KL, Porporatti AL, Warnakulasuriya S, Guerra ENS, Rivero ERC
J Oral Pathol Med 2018 Aug;47(7):633-640. Epub 2018 Jun 6 doi: 10.1111/jop.12726. PMID: 29738071

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