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Alopecia mucinosa

MedGen UID:
1419
•Concept ID:
C0002173
•
Disease or Syndrome
Synonyms: Alopecia Mucinosa; Follicular Mucinoses; Follicular Mucinosis; Mucinoses, Follicular; Mucinosis, Follicular
SNOMED CT: Alopecia mucinosa (27382006); Follicular mucinosis (27382006)
 
Monarch Initiative: MONDO:0006551

Definition

A rare dermatologic disorder characterized by the accumulation of mucinous material in the hair follicles. In some cases it is associated with lymphoproliferative disorders, most often mycosis fungoides and Hodgkin lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAlopecia mucinosa

Professional guidelines

PubMed

Diagnosis and management of primary cicatricial alopecia: part I.
Otberg N, Wu WY, McElwee KJ, Shapiro J
Skinmed 2008 Jan-Feb;7(1):19-26. doi: 10.1111/j.1540-9740.2007.07163.x. PMID: 18174797
Ofuji's disease with follicular mucinosis and its differential diagnosis from alopecia mucinosa.
Lee JY, Tsai YM, Sheu HM
J Cutan Pathol 2003 May;30(5):307-13. doi: 10.1034/j.1600-0560.2003.00076.x. PMID: 12753170

Recent clinical studies

Etiology

Past, present and future of cutaneous lymphomas.
Cerroni L
Semin Diagn Pathol 2017 Jan;34(1):3-14. Epub 2016 Nov 28 doi: 10.1053/j.semdp.2016.11.001. PMID: 27979336
Histologic features of alopecias: part II: scarring alopecias.
Bernárdez C, Molina-Ruiz AM, Requena L
Actas Dermosifiliogr 2015 May;106(4):260-70. Epub 2014 Oct 24 doi: 10.1016/j.ad.2014.06.016. PMID: 25439143
Follicular mucinosis associated with nonlymphoid skin conditions.
Mir-Bonafé JM, Cañueto J, Fernández-López E, Santos-Briz A
Am J Dermatopathol 2014 Sep;36(9):705-9. doi: 10.1097/01.dad.0000451564.29918.31. PMID: 25072678
Clinical features of primary cicatricial alopecia in Chinese patients.
Qi S, Zhao Y, Zhang X, Li S, Cao H, Zhang X
Indian J Dermatol Venereol Leprol 2014 Jul-Aug;80(4):306-12. doi: 10.4103/0378-6323.136833. PMID: 25035354
Alopecia mucinosa and lymphoma. Report of two cases and review of literature.
Plotnick H, Abbrecht M
Arch Dermatol 1965 Aug;92(2):137-41. PMID: 11850912

Diagnosis

Past, present and future of cutaneous lymphomas.
Cerroni L
Semin Diagn Pathol 2017 Jan;34(1):3-14. Epub 2016 Nov 28 doi: 10.1053/j.semdp.2016.11.001. PMID: 27979336
Primary cicatricial alopecia: Other lymphocytic primary cicatricial alopecias and neutrophilic and mixed primary cicatricial alopecias.
Bolduc C, Sperling LC, Shapiro J
J Am Acad Dermatol 2016 Dec;75(6):1101-1117. doi: 10.1016/j.jaad.2015.01.056. PMID: 27846945
Histologic features of alopecias: part II: scarring alopecias.
Bernárdez C, Molina-Ruiz AM, Requena L
Actas Dermosifiliogr 2015 May;106(4):260-70. Epub 2014 Oct 24 doi: 10.1016/j.ad.2014.06.016. PMID: 25439143
Clinical and histopathologic spectrum of alopecia mucinosa/follicular mucinosis and its natural history in children.
Zvulunov A, Shkalim V, Ben-Amitai D, Feinmesser M
J Am Acad Dermatol 2012 Dec;67(6):1174-81. Epub 2012 May 10 doi: 10.1016/j.jaad.2012.04.015. PMID: 22579407
Alopecia mucinosa, inflammatory disease or mycosis fungoides: must we choose? And are there other choices?
LeBoit PE
Am J Dermatopathol 2004 Apr;26(2):167-70. doi: 10.1097/00000372-200404000-00040. PMID: 15024200

Therapy

Combination of tacalcitol ointment and photodynamic therapy for the treatment of follicular mucinosis of the scalp.
Giuffrida R, Borgia F, Marafioti I, Riso G, Cannavò SP
Photodiagnosis Photodyn Ther 2019 Sep;27:487-489. Epub 2019 Jul 9 doi: 10.1016/j.pdpdt.2019.07.003. PMID: 31299390
Treatment of primary follicular mucinosis with imiquimod 5% cream.
Alonso de Celada RM, Feito Rodriguez M, Noguera Morel L, Beato Merino MJ, De Lucas Laguna R
Pediatr Dermatol 2014 May-Jun;31(3):406-8. Epub 2012 Sep 25 doi: 10.1111/j.1525-1470.2012.01852.x. PMID: 23004681
Prominent follicular mucinosis with diffuse scalp alopecia resembling alopecia areata.
Missall TA, Hurley MY, Burkemper NM
J Cutan Pathol 2013 Oct;40(10):887-90. Epub 2013 Aug 21 doi: 10.1111/cup.12201. PMID: 23962142
Alopecia mucinosa: report of a case and review.
Anderson BE, Mackley CL, Helm KF
J Cutan Med Surg 2003 Mar-Apr;7(2):124-8. Epub 2002 Nov 27 doi: 10.1007/s10227-002-0103-8. PMID: 12447614
Follicular mycosis fungoides.
Klemke CD, Dippel E, Assaf C, Hummel M, Stein H, Goerdt S, Orfanos CE
Br J Dermatol 1999 Jul;141(1):137-40. doi: 10.1046/j.1365-2133.1999.02935.x. PMID: 10417530

Prognosis

Past, present and future of cutaneous lymphomas.
Cerroni L
Semin Diagn Pathol 2017 Jan;34(1):3-14. Epub 2016 Nov 28 doi: 10.1053/j.semdp.2016.11.001. PMID: 27979336
Clinical features of primary cicatricial alopecia in Chinese patients.
Qi S, Zhao Y, Zhang X, Li S, Cao H, Zhang X
Indian J Dermatol Venereol Leprol 2014 Jul-Aug;80(4):306-12. doi: 10.4103/0378-6323.136833. PMID: 25035354
Alopecia mucinosa: report of a case and review.
Anderson BE, Mackley CL, Helm KF
J Cutan Med Surg 2003 Mar-Apr;7(2):124-8. Epub 2002 Nov 27 doi: 10.1007/s10227-002-0103-8. PMID: 12447614
Follicular mycosis fungoides.
Klemke CD, Dippel E, Assaf C, Hummel M, Stein H, Goerdt S, Orfanos CE
Br J Dermatol 1999 Jul;141(1):137-40. doi: 10.1046/j.1365-2133.1999.02935.x. PMID: 10417530
Alopecia mucinosa and lymphoma. Report of two cases and review of literature.
Plotnick H, Abbrecht M
Arch Dermatol 1965 Aug;92(2):137-41. PMID: 11850912

Clinical prediction guides

Follicular mucinosis associated with nonlymphoid skin conditions.
Mir-Bonafé JM, Cañueto J, Fernández-López E, Santos-Briz A
Am J Dermatopathol 2014 Sep;36(9):705-9. doi: 10.1097/01.dad.0000451564.29918.31. PMID: 25072678
Clinical and histopathologic spectrum of alopecia mucinosa/follicular mucinosis and its natural history in children.
Zvulunov A, Shkalim V, Ben-Amitai D, Feinmesser M
J Am Acad Dermatol 2012 Dec;67(6):1174-81. Epub 2012 May 10 doi: 10.1016/j.jaad.2012.04.015. PMID: 22579407
Failure to detect clonality in eosinophilic pustular folliculitis with follicular mucinosis.
Lee MW, Lee DP, Choi JH, Moon KC, Koh JK
Acta Derm Venereol 2004;84(4):305-7. doi: 10.1080/00015550410026966. PMID: 15339077
Alopecia mucinosa is mycosis fungoides.
Böer A, Guo Y, Ackerman AB
Am J Dermatopathol 2004 Feb;26(1):33-52. doi: 10.1097/00000372-200402000-00006. PMID: 14726821
Ofuji's disease with follicular mucinosis and its differential diagnosis from alopecia mucinosa.
Lee JY, Tsai YM, Sheu HM
J Cutan Pathol 2003 May;30(5):307-13. doi: 10.1034/j.1600-0560.2003.00076.x. PMID: 12753170

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