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Lack of gonadotropin-releasing hormone pulsatility

MedGen UID:
1392189
•Concept ID:
C4477074
•
Finding
Synonym: Absence of GnRH pulsatility
 
HPO: HP:0500013

Definition

Secretion of gonadotropin-releasing hormone that does not occur in a pulsatile fashion. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLack of gonadotropin-releasing hormone pulsatility

Professional guidelines

PubMed

Pulsatile patterns of melatonin secretion in patients with gonadotropin-releasing hormone deficiency: effects of testosterone treatment.
Luboshitzky R, Herer P, Lavie P
J Pineal Res 1997 Mar;22(2):95-101. doi: 10.1111/j.1600-079x.1997.tb00309.x. PMID: 9181521
Changes in the kinetics and biopotency of luteinizing hormone in hemodialyzed men during treatment with recombinant human erythropoietin.
Schaefer F, van Kaick B, Veldhuis JD, Stein G, Schärer K, Robertson WR, Ritz E
J Am Soc Nephrol 1994 Nov;5(5):1208-15. doi: 10.1681/ASN.V551208. PMID: 7873731

Recent clinical studies

Etiology

Lactational Amenorrhea: Neuroendocrine Pathways Controlling Fertility and Bone Turnover.
Calik-Ksepka A, Stradczuk M, Czarnecka K, Grymowicz M, Smolarczyk R
Int J Mol Sci 2022 Jan 31;23(3) doi: 10.3390/ijms23031633. PMID: 35163554Free PMC Article
Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men.
Roelfsema F, Yang RJ, Takahashi PY, Erickson D, Bowers CY, Veldhuis JD
J Clin Endocrinol Metab 2018 Dec 1;103(12):4419-4427. doi: 10.1210/jc.2018-00755. PMID: 30032193Free PMC Article
Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women.
Skorupskaite K, George JT, Veldhuis JD, Millar RP, Anderson RA
Neuroendocrinology 2018;106(2):148-157. Epub 2017 Apr 5 doi: 10.1159/000473893. PMID: 28380486
Hormonal control of spermatogenesis in men: therapeutic aspects in hypogonadotropic hypogonadism.
Pitteloud N, Dwyer A
Ann Endocrinol (Paris) 2014 May;75(2):98-100. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.002. PMID: 24793994
Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testotoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxyprogesterone acetate therapy in four cases.
Rosenthal SM, Grumbach MM, Kaplan SL
J Clin Endocrinol Metab 1983 Sep;57(3):571-9. doi: 10.1210/jcem-57-3-571. PMID: 6223935

Diagnosis

Sensitivity and specificity of pulse detection using a new deconvolution method.
Liu PY, Keenan DM, Kok P, Padmanabhan V, O'Byrne KT, Veldhuis JD
Am J Physiol Endocrinol Metab 2009 Aug;297(2):E538-44. Epub 2009 Jun 16 doi: 10.1152/ajpendo.00071.2009. PMID: 19531646Free PMC Article
AutoDecon, a deconvolution algorithm for identification and characterization of luteinizing hormone secretory bursts: description and validation using synthetic data.
Johnson ML, Pipes L, Veldhuis PP, Farhy LS, Boyd DG, Evans WS
Anal Biochem 2008 Oct 1;381(1):8-17. Epub 2008 Jul 4 doi: 10.1016/j.ab.2008.07.001. PMID: 18639514Free PMC Article
Changes in the kinetics and biopotency of luteinizing hormone in hemodialyzed men during treatment with recombinant human erythropoietin.
Schaefer F, van Kaick B, Veldhuis JD, Stein G, Schärer K, Robertson WR, Ritz E
J Am Soc Nephrol 1994 Nov;5(5):1208-15. doi: 10.1681/ASN.V551208. PMID: 7873731
Follicle stimulating hormone-secreting pituitary adenoma: inappropriate secretion and effect of pulsatile luteinizing hormone releasing hormone analogue (buserelin) administration.
Damjanović S, Micić D, Popović V, Petakov M, Kendereski A, Sumarac M, Manojlović D, Mićić J
J Endocrinol Invest 1991 Apr;14(4):299-304. doi: 10.1007/BF03346818. PMID: 1713932
Control of prolactin secretion.
Benker G, Jaspers C, Häusler G, Reinwein D
Klin Wochenschr 1990 Dec 4;68(23):1157-67. doi: 10.1007/BF01815271. PMID: 2126309

Therapy

Hormonal control of spermatogenesis in men: therapeutic aspects in hypogonadotropic hypogonadism.
Pitteloud N, Dwyer A
Ann Endocrinol (Paris) 2014 May;75(2):98-100. Epub 2014 Apr 29 doi: 10.1016/j.ando.2014.04.002. PMID: 24793994
LHRH analogues: their clinical physiology and delivery systems.
Fraser HM
Baillieres Clin Obstet Gynaecol 1988 Sep;2(3):639-58. doi: 10.1016/s0950-3552(88)80050-6. PMID: 3069267
Gonadotropin-releasing hormone (GnRH) physiology in men and women.
Santoro N, Filicori M, Spratt D, Crowley WF Jr
Acta Med Hung 1986;43(2):201-21. PMID: 3295743
Clinical applications of LHRH and its analogues.
Sandow J
Clin Endocrinol (Oxf) 1983 Jun;18(6):571-92. doi: 10.1111/j.1365-2265.1983.tb00595.x. PMID: 6136347
Hyperprolactinemic anovulatory syndrome.
Bohnet HG, Dahlén HG, Wuttke W, Schneider HP
J Clin Endocrinol Metab 1976 Jan;42(1):132-43. doi: 10.1210/jcem-42-1-132. PMID: 765352

Prognosis

Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?
Armstrong SP, Caunt CJ, Fowkes RC, Tsaneva-Atanasova K, McArdle CA
J Biol Chem 2009 Dec 18;284(51):35746-57. doi: 10.1074/jbc.M109.063917. PMID: 19858197Free PMC Article

Clinical prediction guides

Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?
Armstrong SP, Caunt CJ, Fowkes RC, Tsaneva-Atanasova K, McArdle CA
J Biol Chem 2009 Dec 18;284(51):35746-57. doi: 10.1074/jbc.M109.063917. PMID: 19858197Free PMC Article
Pulsatile patterns of melatonin secretion in patients with gonadotropin-releasing hormone deficiency: effects of testosterone treatment.
Luboshitzky R, Herer P, Lavie P
J Pineal Res 1997 Mar;22(2):95-101. doi: 10.1111/j.1600-079x.1997.tb00309.x. PMID: 9181521
Lack of effect of the alpha-adrenergic agonist clonidine on pulsatile luteinizing hormone secretion in a double blind study in men.
Kaufman JM, Vermeulen A
J Clin Endocrinol Metab 1989 Jan;68(1):219-22. doi: 10.1210/jcem-68-1-219. PMID: 2642486
Gonadotropin-releasing hormone (GnRH) physiology in men and women.
Santoro N, Filicori M, Spratt D, Crowley WF Jr
Acta Med Hung 1986;43(2):201-21. PMID: 3295743
Hyperprolactinemic anovulatory syndrome.
Bohnet HG, Dahlén HG, Wuttke W, Schneider HP
J Clin Endocrinol Metab 1976 Jan;42(1):132-43. doi: 10.1210/jcem-42-1-132. PMID: 765352

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