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Central Nervous System Intravascular Large B-Cell Lymphoma

MedGen UID:
1391195
•Concept ID:
C4329633
•
Neoplastic Process

Definition

A rare extranodal B-cell non-Hodgkin lymphoma that affects the central nervous system. It is characterized by the presence of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Intravascular Large B-Cell Lymphoma

Professional guidelines

PubMed

Clinicopathological correlates of primary central nervous system lymphoma: experience from a tertiary care center in South India.
Patel B, Chacko G, Nair S, Anandan J, Chacko AG, Rajshekhar V, Turel M
Neurol India 2015 Jan-Feb;63(1):77-82. doi: 10.4103/0028-3886.152658. PMID: 25751474

Recent clinical studies

Etiology

Clinical features and imaging manifestations for intravascular large B-cell lymphoma.
Jin H, Liao W, Yang S, Peng L, Xing W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Dec 28;48(12):1920-1928. doi: 10.11817/j.issn.1672-7347.2023.230305. PMID: 38448386Free PMC Article
Intravascular Large B-Cell Lymphoma: A Review with a Focus on the Prognostic Value of Skin Involvement.
Breakell T, Waibel H, Schliep S, Ferstl B, Erdmann M, Berking C, Heppt MV
Curr Oncol 2022 Apr 19;29(5):2909-2919. doi: 10.3390/curroncol29050237. PMID: 35621627Free PMC Article
Current progress and future perspectives of research on intravascular large B-cell lymphoma.
Shimada K, Kiyoi H
Cancer Sci 2021 Oct;112(10):3953-3961. Epub 2021 Aug 9 doi: 10.1111/cas.15091. PMID: 34327781Free PMC Article
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
CNS lymphoma: a practical diagnostic approach.
Giannini C, Dogan A, Salomão DR
J Neuropathol Exp Neurol 2014 Jun;73(6):478-94. doi: 10.1097/NEN.0000000000000076. PMID: 24806301

Diagnosis

Intravascular large cell B lymphoma presenting as central nervous system pseudo-vasculitis: A rare diagnostic challenge.
Vandermeersch D, Mahsouli A, Willemart M, Scoppettuolo P, Van de Wyngaert C, Van den Neste E, Camboni A, Lawson M, Onofrj V, Pothen L
Neuroradiol J 2024 Oct;37(5):651-655. Epub 2023 Nov 7 doi: 10.1177/19714009231212351. PMID: 37933603Free PMC Article
Diffuse large B-cell lymphoma variants: an update.
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Intravascular large B-cell lymphoma.
Orwat DE, Batalis NI
Arch Pathol Lab Med 2012 Mar;136(3):333-8. doi: 10.5858/arpa.2010-0747-RS. PMID: 22372911
Intravascular B-cell lymphoma.
Erös N, Károlyi Z, Kovács A, Takács I, Radványi G, Kelényi G
J Am Acad Dermatol 2002 Nov;47(5 Suppl):S260-2. doi: 10.1067/mjd.2002.108493. PMID: 12399744

Therapy

Limited efficacy of high-dose methotrexate to prevent the central nervous system relapse in patients with IVLBCL.
Terao T, Tsushima T, Ikeda D, Fukumoto A, Kamura Y, Kuzume A, Tabata R, Miura D, Narita K, Takeuchi M, Matsue K
Leuk Lymphoma 2022 Dec;63(14):3394-3401. Epub 2022 Sep 16 doi: 10.1080/10428194.2022.2123239. PMID: 36111741
Intravascular Large B-Cell Lymphoma: A Review with a Focus on the Prognostic Value of Skin Involvement.
Breakell T, Waibel H, Schliep S, Ferstl B, Erdmann M, Berking C, Heppt MV
Curr Oncol 2022 Apr 19;29(5):2909-2919. doi: 10.3390/curroncol29050237. PMID: 35621627Free PMC Article
Current progress and future perspectives of research on intravascular large B-cell lymphoma.
Shimada K, Kiyoi H
Cancer Sci 2021 Oct;112(10):3953-3961. Epub 2021 Aug 9 doi: 10.1111/cas.15091. PMID: 34327781Free PMC Article
Intravascular Large B-cell Lymphoma Associated with Systemic and Central Nervous System Hemophagocytic Lymphohistiocytosis: A Case Report.
Verma A, Sharma A, Robetorye R, Porter A, Hilal T
Perm J 2020;24 Epub 2019 Dec 6 doi: 10.7812/TPP/19.105. PMID: 31852057Free PMC Article
Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.
Shimada K, Murase T, Matsue K, Okamoto M, Ichikawa N, Tsukamoto N, Niitsu N, Miwa H, Asaoku H, Kosugi H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamamoto K, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T; IVL Study Group in Japan
Cancer Sci 2010 Jun;101(6):1480-6. Epub 2010 Mar 6 doi: 10.1111/j.1349-7006.2010.01555.x. PMID: 20412122Free PMC Article

Prognosis

Clinical features and imaging manifestations for intravascular large B-cell lymphoma.
Jin H, Liao W, Yang S, Peng L, Xing W
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2023 Dec 28;48(12):1920-1928. doi: 10.11817/j.issn.1672-7347.2023.230305. PMID: 38448386Free PMC Article
Intravascular Large B-Cell Lymphoma: A Review with a Focus on the Prognostic Value of Skin Involvement.
Breakell T, Waibel H, Schliep S, Ferstl B, Erdmann M, Berking C, Heppt MV
Curr Oncol 2022 Apr 19;29(5):2909-2919. doi: 10.3390/curroncol29050237. PMID: 35621627Free PMC Article
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks.
Ponzoni M, Campo E, Nakamura S
Blood 2018 Oct 11;132(15):1561-1567. Epub 2018 Aug 15 doi: 10.1182/blood-2017-04-737445. PMID: 30111607
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Intravascular lymphomatosis.
Lui PC, Wong GK, Poon WS, Tse GM
J Clin Pathol 2003 Jun;56(6):468-70. doi: 10.1136/jcp.56.6.468. PMID: 12783976Free PMC Article

Clinical prediction guides

Progressive conus medullaris lesions are suggestive of intravascular large B-cell lymphoma.
Kitahara S, Kanazawa M, Natsumeda M, Sato A, Ishikawa M, Hara K, Tabe H, Makino K, Okamoto K, Fujita N, Kakita A, Fuji Y, Onodera O
Eur J Neurol 2023 Oct;30(10):3236-3243. Epub 2023 Jul 4 doi: 10.1111/ene.15941. PMID: 37350144
Limited efficacy of high-dose methotrexate to prevent the central nervous system relapse in patients with IVLBCL.
Terao T, Tsushima T, Ikeda D, Fukumoto A, Kamura Y, Kuzume A, Tabata R, Miura D, Narita K, Takeuchi M, Matsue K
Leuk Lymphoma 2022 Dec;63(14):3394-3401. Epub 2022 Sep 16 doi: 10.1080/10428194.2022.2123239. PMID: 36111741
Asian variant of intravascular large B-cell lymphoma: a comparison of clinical features based on involvement of the central nervous system.
Yoon SE, Kim WS, Kim SJ
Korean J Intern Med 2020 Jul;35(4):946-956. Epub 2019 Nov 25 doi: 10.3904/kjim.2018.396. PMID: 31752477Free PMC Article
Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks.
Ponzoni M, Campo E, Nakamura S
Blood 2018 Oct 11;132(15):1561-1567. Epub 2018 Aug 15 doi: 10.1182/blood-2017-04-737445. PMID: 30111607
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article

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