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Increased reactive oxygen species production

MedGen UID:
1390274
•Concept ID:
C4476796
•
Cell or Molecular Dysfunction
Synonyms: Increased ROS production; Oxidative stress
 
HPO: HP:0025464

Definition

An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased reactive oxygen species production

Professional guidelines

PubMed

Effects of Stromal Cell Conditioned Medium and Antipurinergic Treatment on Macrophage Phenotype.
Arabiyat AS, Yeisley DJ, Güiza-Argüello VR, Qureshi F, Culibrk RA, Hahn J, Hahn MS
Tissue Eng Part C Methods 2022 Dec;28(12):656-671. doi: 10.1089/ten.TEC.2022.0123. PMID: 36329666Free PMC Article
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
Pharmacol Ther 2014 Jun;142(3):375-415. Epub 2014 Jan 22 doi: 10.1016/j.pharmthera.2014.01.003. PMID: 24462787

Recent clinical studies

Etiology

Lifestyle factors as determinants of atherosclerotic cardiovascular health.
Schmidt-Trucksäss A, Lichtenstein AH, von Känel R
Atherosclerosis 2024 Aug;395:117577. Epub 2024 May 10 doi: 10.1016/j.atherosclerosis.2024.117577. PMID: 38852021
The Relationship between Serum Bilirubin and Inflammatory Bowel Disease.
Zhao X, Li L, Li X, Li J, Wang D, Zhang H
Mediators Inflamm 2019;2019:5256460. Epub 2019 Apr 15 doi: 10.1155/2019/5256460. PMID: 31148945Free PMC Article
The Phototoxic Potential of the Flavonoids, Taxifolin and Quercetin.
Rajnochová Svobodová A, Ryšavá A, Psotová M, Kosina P, Zálešák B, Ulrichová J, Vostálová J
Photochem Photobiol 2017 Oct;93(5):1240-1247. Epub 2017 Apr 27 doi: 10.1111/php.12755. PMID: 28303596
From fatty liver to fibrosis: a tale of "second hit".
Basaranoglu M, Basaranoglu G, Sentürk H
World J Gastroenterol 2013 Feb 28;19(8):1158-65. doi: 10.3748/wjg.v19.i8.1158. PMID: 23483818Free PMC Article
High-mobility group box 1, oxidative stress, and disease.
Tang D, Kang R, Zeh HJ 3rd, Lotze MT
Antioxid Redox Signal 2011 Apr 1;14(7):1315-35. doi: 10.1089/ars.2010.3356. PMID: 20969478Free PMC Article

Diagnosis

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells.
Yang C, Song J, Hwang S, Choi J, Song G, Lim W
Redox Biol 2021 Nov;47:102144. Epub 2021 Sep 21 doi: 10.1016/j.redox.2021.102144. PMID: 34562873Free PMC Article
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Traumatic brain injury and mitochondrial dysfunction.
Hiebert JB, Shen Q, Thimmesch AR, Pierce JD
Am J Med Sci 2015 Aug;350(2):132-8. doi: 10.1097/MAJ.0000000000000506. PMID: 26083647
Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle.
Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Højlund K, Yi Z, Mandarino LJ
Diabetes 2010 Oct;59(10):2444-52. Epub 2010 Aug 3 doi: 10.2337/db10-0174. PMID: 20682693Free PMC Article

Therapy

A review of stimuli-responsive polymeric micelles for tumor-targeted delivery of curcumin.
Qiu N, Du X, Ji J, Zhai G
Drug Dev Ind Pharm 2021 Jun;47(6):839-856. Epub 2021 Jun 24 doi: 10.1080/03639045.2021.1934869. PMID: 34033496
Dichloroacetate-induced peripheral neuropathy.
Stacpoole PW, Martyniuk CJ, James MO, Calcutt NA
Int Rev Neurobiol 2019;145:211-238. Epub 2019 Jun 11 doi: 10.1016/bs.irn.2019.05.003. PMID: 31208525
Nanoparticles of methylene blue enhance photodynamic therapy.
Jesus VPS, Raniero L, Lemes GM, Bhattacharjee TT, Caetano Júnior PC, Castilho ML
Photodiagnosis Photodyn Ther 2018 Sep;23:212-217. Epub 2018 Jun 19 doi: 10.1016/j.pdpdt.2018.06.011. PMID: 29928992
Oxidative stress and antioxidant treatment in patients with peripheral artery disease.
Koutakis P, Ismaeel A, Farmer P, Purcell S, Smith RS, Eidson JL, Bohannon WT
Physiol Rep 2018 Apr;6(7):e13650. doi: 10.14814/phy2.13650. PMID: 29611350Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article

Prognosis

Phenotypic and functional characterisation of synovial fluid-derived neutrophils in knee osteoarthritis and knee infection.
Manukyan G, Gallo J, Mikulkova Z, Trajerova M, Savara J, Slobodova Z, Fidler E, Shrestha B, Kriegova E
Osteoarthritis Cartilage 2023 Jan;31(1):72-82. Epub 2022 Oct 7 doi: 10.1016/j.joca.2022.09.011. PMID: 36216277
Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia.
Alonso-Peña M, Espinosa-Escudero R, Herraez E, Briz O, Cagigal ML, Gonzalez-Santiago JM, Ortega-Alonso A, Fernandez-Rodriguez C, Bujanda L, Calvo Sanchez M, D Avola D, Londoño MC, Diago M, Fernandez-Checa JC, Garcia-Ruiz C, Andrade RJ, Lammert F, Prieto J, Crespo J, Juamperez J, Diaz-Gonzalez A, Monte MJ, Marin JJG
Hepatology 2022 Nov;76(5):1259-1274. Epub 2022 Jul 1 doi: 10.1002/hep.32517. PMID: 35395098Free PMC Article
MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo.
Sahoo A, Lee B, Boniface K, Seneschal J, Sahoo SK, Seki T, Wang C, Das S, Han X, Steppie M, Seal S, Taieb A, Perera RJ
J Invest Dermatol 2017 Sep;137(9):1965-1974. Epub 2017 May 11 doi: 10.1016/j.jid.2017.04.025. PMID: 28502800Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Protein carbamylation and cardiovascular disease.
Verbrugge FH, Tang WH, Hazen SL
Kidney Int 2015 Sep;88(3):474-8. Epub 2015 Jun 10 doi: 10.1038/ki.2015.166. PMID: 26061545Free PMC Article

Clinical prediction guides

T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1.
Wang C, He J, Jin H, Xiao H, Peng S, Xie J, Zhang L, Guo J
Chemosphere 2023 Nov;341:140087. Epub 2023 Sep 5 doi: 10.1016/j.chemosphere.2023.140087. PMID: 37678596
Exploring the Anticancer Activity of Tamoxifen-Based Metal Complexes Targeting Mitochondria.
Scalcon V, Bonsignore R, Aupič J, Thomas SR, Folda A, Heidecker AA, Pöthig A, Magistrato A, Casini A, Rigobello MP
J Med Chem 2023 Jul 27;66(14):9823-9841. Epub 2023 Jul 6 doi: 10.1021/acs.jmedchem.3c00617. PMID: 37410388Free PMC Article
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.
Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC
Nat Med 2016 May;22(5):547-56. Epub 2016 Apr 18 doi: 10.1038/nm.4087. PMID: 27089514Free PMC Article
Traumatic brain injury and mitochondrial dysfunction.
Hiebert JB, Shen Q, Thimmesch AR, Pierce JD
Am J Med Sci 2015 Aug;350(2):132-8. doi: 10.1097/MAJ.0000000000000506. PMID: 26083647
From fatty liver to fibrosis: a tale of "second hit".
Basaranoglu M, Basaranoglu G, Sentürk H
World J Gastroenterol 2013 Feb 28;19(8):1158-65. doi: 10.3748/wjg.v19.i8.1158. PMID: 23483818Free PMC Article

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