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Decreased CSF protein concentration

MedGen UID:
1387378
•Concept ID:
C4476790
•
Finding
Synonym: Decreased CSF total protein
 
HPO: HP:0025457

Definition

CSF total protein level is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased CSF protein concentration

Professional guidelines

PubMed

Treatment of Kearns-Sayre syndrome with coenzyme Q10.
Ogasahara S, Nishikawa Y, Yorifuji S, Soga F, Nakamura Y, Takahashi M, Hashimoto S, Kono N, Tarui S
Neurology 1986 Jan;36(1):45-53. doi: 10.1212/wnl.36.1.45. PMID: 3941783

Recent clinical studies

Etiology

Myd88 Signaling Is Involved in the Inflammatory Response in LPS-Induced Mouse Epididymitis and Bone-Marrow-Derived Dendritic Cells.
Liu JC, Wang P, Zeng QX, Yang C, Lyu M, Li Y, Yeung WS, Chiu PC, Haidl G, Allam JP, Duan YG
Int J Mol Sci 2023 Apr 25;24(9) doi: 10.3390/ijms24097838. PMID: 37175545Free PMC Article
Prevention of chemotherapy-induced neutropenia with pegfilgrastim: pharmacokinetics and patient outcomes.
Yang BB, Savin MA, Green M
Chemotherapy 2012;58(5):387-98. Epub 2012 Dec 28 doi: 10.1159/000345626. PMID: 23296266
Monitoring malignant melanoma with the S-100B tumour marker.
Bonfrer JM, Korse CM
Recent Results Cancer Res 2001;158:149-57. doi: 10.1007/978-3-642-59537-0_15. PMID: 11092042
Reduced cerebrospinal fluid B-endorphin levels in Rett syndrome.
Genazzani AR, Zappella M, Nalin A, Hayek Y, Facchinetti F
Childs Nerv Syst 1989 Apr;5(2):111-3. doi: 10.1007/BF00571121. PMID: 2544265
Genetic hypothesis of idiopathic schizophrenia: its exorphin connection.
Dohan FC
Schizophr Bull 1988;14(4):489-94. doi: 10.1093/schbul/14.4.489. PMID: 2851166

Diagnosis

Development of a Low-Molecular-Weight Aβ42 Detection System Using a Enzyme-Linked Peptide Assay.
Kim SH, Lee EH, Kim HJ, Kim AR, Kim YE, Lee JH, Yoon MY, Koh SH
Biomolecules 2021 Dec 2;11(12) doi: 10.3390/biom11121818. PMID: 34944462Free PMC Article
Preclinical Assessment of Leptin Transport into the Cerebrospinal Fluid in Diet-Induced Obese Minipigs.
Chmielewski A, Hubert T, Descamps A, Mazur D, Daoudi M, Ciofi P, Fontaine C, Caiazzo R, Pattou F, Prevot V, Pigeyre M
Obesity (Silver Spring) 2019 Jun;27(6):950-956. Epub 2019 Apr 21 doi: 10.1002/oby.22465. PMID: 31006983Free PMC Article
Simultaneous quantitation of the BACE1 inhibitor AZD3293 and its metabolite AZ13569724 in human matrices by LC-MS/MS.
Li Y, Severin PH, Hoffmann MR, Miller DL, Monk SA, Kugler AR
Bioanalysis 2017 May;9(10):813-826. Epub 2017 Apr 24 doi: 10.4155/bio-2017-0003. PMID: 28434245
Quantitation of IgG kappa and IgG lambda in the cerebrospinal fluid by sandwich ELISA method.
Zeman D, Kušnierová P, Bojková J, Všianský F, Zapletalová O
J Immunoassay Immunochem 2017;38(2):165-177. Epub 2016 Sep 9 doi: 10.1080/15321819.2016.1233889. PMID: 27611231
Antemortem laboratory diagnosis of Alzheimer's disease.
Gauthier S, Robitaille Y, Quirion R, Leblanc R
Prog Neuropsychopharmacol Biol Psychiatry 1986;10(3-5):391-403. doi: 10.1016/0278-5846(86)90013-8. PMID: 3541044

Therapy

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller T, Cudkowicz M, Shaw PJ, Andersen PM, Atassi N, Bucelli RC, Genge A, Glass J, Ladha S, Ludolph AL, Maragakis NJ, McDermott CJ, Pestronk A, Ravits J, Salachas F, Trudell R, Van Damme P, Zinman L, Bennett CF, Lane R, Sandrock A, Runz H, Graham D, Houshyar H, McCampbell A, Nestorov I, Chang I, McNeill M, Fanning L, Fradette S, Ferguson TA
N Engl J Med 2020 Jul 9;383(2):109-119. doi: 10.1056/NEJMoa2003715. PMID: 32640130
Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.
Poirier J, Miron J, Picard C, Gormley P, Théroux L, Breitner J, Dea D
Neurobiol Aging 2014 Sep;35 Suppl 2(Suppl 2):S3-10. Epub 2014 May 15 doi: 10.1016/j.neurobiolaging.2014.03.037. PMID: 24973118Free PMC Article
Prevention of chemotherapy-induced neutropenia with pegfilgrastim: pharmacokinetics and patient outcomes.
Yang BB, Savin MA, Green M
Chemotherapy 2012;58(5):387-98. Epub 2012 Dec 28 doi: 10.1159/000345626. PMID: 23296266
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630
Genetic hypothesis of idiopathic schizophrenia: its exorphin connection.
Dohan FC
Schizophr Bull 1988;14(4):489-94. doi: 10.1093/schbul/14.4.489. PMID: 2851166

Prognosis

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study.
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network
Lancet Neurol 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339Free PMC Article
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630
CSF amyloid beta42 and tau levels correlate with AIDS dementia complex.
Brew BJ, Pemberton L, Blennow K, Wallin A, Hagberg L
Neurology 2005 Nov 8;65(9):1490-2. doi: 10.1212/01.wnl.0000183293.95787.b7. PMID: 16275845
Monitoring malignant melanoma with the S-100B tumour marker.
Bonfrer JM, Korse CM
Recent Results Cancer Res 2001;158:149-57. doi: 10.1007/978-3-642-59537-0_15. PMID: 11092042

Clinical prediction guides

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study.
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, Morris JC, Kleinberger G, Nellgard B, Vöglein J, Blennow K, Zetterberg H, Ewers M, Jucker M, Levin J, Bateman RJ, Haass C; Dominantly Inherited Alzheimer Network
Lancet Neurol 2022 Apr;21(4):329-341. doi: 10.1016/S1474-4422(22)00027-8. PMID: 35305339Free PMC Article
Quantitation of IgG kappa and IgG lambda in the cerebrospinal fluid by sandwich ELISA method.
Zeman D, Kušnierová P, Bojková J, Všianský F, Zapletalová O
J Immunoassay Immunochem 2017;38(2):165-177. Epub 2016 Sep 9 doi: 10.1080/15321819.2016.1233889. PMID: 27611231
Pharmacokinetics and pharmacodynamics of pegfilgrastim.
Yang BB, Kido A
Clin Pharmacokinet 2011 May;50(5):295-306. doi: 10.2165/11586040-000000000-00000. PMID: 21456630
Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/beta-trace in canine.
Li W, Mase M, Inui T, Shimoda M, Isomura K, Oda H, Yamada K, Urade Y
Neurosci Res 2008 Jul;61(3):289-93. Epub 2008 Apr 1 doi: 10.1016/j.neures.2008.03.006. PMID: 18471915
CSF hypocretin-1/orexin-A concentrations in patients with subarachnoid hemorrhage (SAH).
Dohi K, Ripley B, Fujiki N, Ohtaki H, Shioda S, Aruga T, Nishino S
Peptides 2005 Nov;26(11):2339-43. doi: 10.1016/j.peptides.2005.04.004. PMID: 15893406

Recent systematic reviews

Central Inflammatory Cytokines in Tuberculous Meningitis: A Systematic Review and Meta-analysis.
Saghazadeh A, Rezaei N
J Interferon Cytokine Res 2022 Mar;42(3):95-107. doi: 10.1089/jir.2021.0176. PMID: 35298290
Biological fluid levels of iron and iron-related proteins in Parkinson's disease: Review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG
Eur J Neurol 2021 Mar;28(3):1041-1055. Epub 2020 Dec 1 doi: 10.1111/ene.14607. PMID: 33098743
A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I).
Reddy VS, Bukke S, Dutt N, Rana P, Pandey AK
J Trace Elem Med Biol 2017 Jul;42:68-75. Epub 2017 Apr 23 doi: 10.1016/j.jtemb.2017.04.005. PMID: 28595794
Cerebrospinal fluid Aβ42, t-tau, and p-tau levels in the differential diagnosis of idiopathic normal-pressure hydrocephalus: a systematic review and meta-analysis.
Chen Z, Liu C, Zhang J, Relkin N, Xing Y, Li Y
Fluids Barriers CNS 2017 May 10;14(1):13. doi: 10.1186/s12987-017-0062-5. PMID: 28486988Free PMC Article
Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis.
van Dongen RM, Zielman R, Noga M, Dekkers OM, Hankemeier T, van den Maagdenberg AM, Terwindt GM, Ferrari MD
Cephalalgia 2017 Jan;37(1):49-63. Epub 2016 Sep 30 doi: 10.1177/0333102415625614. PMID: 26888294

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