U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Granulomatous cholangitis

MedGen UID:
1386271
Concept ID:
C4476897
Disease or Syndrome
HPO: HP:0030988

Definition

Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGranulomatous cholangitis

Professional guidelines

PubMed

Lee HE, Churg A, Ryu JH, Bilawich AM, Larsen BT, Tazelaar HD, Yi ES
Hum Pathol 2018 Dec;82:177-186. Epub 2018 Jul 29 doi: 10.1016/j.humpath.2018.07.021. PMID: 30067952
Burman BE, Jhaveri MA, Kowdley KV
Clin Liver Dis 2017 Nov;21(4):709-723. Epub 2017 Jul 26 doi: 10.1016/j.cld.2017.06.005. PMID: 28987258
Cheifetz A, Itzkowitz S
J Clin Gastroenterol 2004 May-Jun;38(5 Suppl 1):S44-50. doi: 10.1097/01.mcg.0000124001.93146.ef. PMID: 15115932

Recent clinical studies

Etiology

Otsuka S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Nagino M
Br J Surg 2019 Oct;106(11):1504-1511. Epub 2019 Aug 6 doi: 10.1002/bjs.11257. PMID: 31386198
Di Giorgio A, D'Adda A, Marseglia A, Sonzogni A, Licini L, Nicastro E, D'Antiga L
Hepatol Int 2019 Jul;13(4):510-518. Epub 2019 May 8 doi: 10.1007/s12072-019-09948-1. PMID: 31069759
Hirschfield GM, Liu X, Xu C, Lu Y, Xie G, Lu Y, Gu X, Walker EJ, Jing K, Juran BD, Mason AL, Myers RP, Peltekian KM, Ghent CN, Coltescu C, Atkinson EJ, Heathcote EJ, Lazaridis KN, Amos CI, Siminovitch KA
N Engl J Med 2009 Jun 11;360(24):2544-55. Epub 2009 May 20 doi: 10.1056/NEJMoa0810440. PMID: 19458352Free PMC Article
Ludwig J, Colina F, Poterucha JJ
Liver 1995 Dec;15(6):307-12. doi: 10.1111/j.1600-0676.1995.tb00690.x. PMID: 8609810
Elleder M
Acta Histochem 1986;79(1):1-10. doi: 10.1016/S0065-1281(86)80091-5. PMID: 2874682

Diagnosis

Fujisaki S, Takashina M, Sakurai KI, Tomita R, Takayama T
BMC Gastroenterol 2020 Nov 4;20(1):369. doi: 10.1186/s12876-020-01519-1. PMID: 33148196Free PMC Article
Otsuka S, Ebata T, Yokoyama Y, Igami T, Mizuno T, Yamaguchi J, Onoe S, Watanabe N, Shimoyama Y, Nagino M
Br J Surg 2019 Oct;106(11):1504-1511. Epub 2019 Aug 6 doi: 10.1002/bjs.11257. PMID: 31386198
Di Giorgio A, D'Adda A, Marseglia A, Sonzogni A, Licini L, Nicastro E, D'Antiga L
Hepatol Int 2019 Jul;13(4):510-518. Epub 2019 May 8 doi: 10.1007/s12072-019-09948-1. PMID: 31069759
Ishak KG
Mayo Clin Proc 1998 May;73(5):467-72. doi: 10.1016/S0025-6196(11)63733-6. PMID: 9581591
Ludwig J, Colina F, Poterucha JJ
Liver 1995 Dec;15(6):307-12. doi: 10.1111/j.1600-0676.1995.tb00690.x. PMID: 8609810

Therapy

Di Giorgio A, D'Adda A, Marseglia A, Sonzogni A, Licini L, Nicastro E, D'Antiga L
Hepatol Int 2019 Jul;13(4):510-518. Epub 2019 May 8 doi: 10.1007/s12072-019-09948-1. PMID: 31069759
Iwata M, Sasaki M, Harada K, Kaneko S, Kobayashi K, Adachi K, Sasaki M, Nakanuma Y
Pathol Res Pract 2001;197(1):59-63. doi: 10.1078/0344-0338-00011. PMID: 11209818
Taylor SL, Dean PJ, Riely CA
Am J Surg Pathol 1994 Jan;18(1):91-9. PMID: 8279631

Prognosis

Fujisaki S, Takashina M, Sakurai KI, Tomita R, Takayama T
BMC Gastroenterol 2020 Nov 4;20(1):369. doi: 10.1186/s12876-020-01519-1. PMID: 33148196Free PMC Article
Di Giorgio A, D'Adda A, Marseglia A, Sonzogni A, Licini L, Nicastro E, D'Antiga L
Hepatol Int 2019 Jul;13(4):510-518. Epub 2019 May 8 doi: 10.1007/s12072-019-09948-1. PMID: 31069759
Taylor SL, Dean PJ, Riely CA
Am J Surg Pathol 1994 Jan;18(1):91-9. PMID: 8279631
Anthony PP, Sarsfield P, Clarke T
J Clin Pathol 1990 Dec;43(12):1007-13. doi: 10.1136/jcp.43.12.1007. PMID: 2266172Free PMC Article
Elleder M
Acta Histochem 1986;79(1):1-10. doi: 10.1016/S0065-1281(86)80091-5. PMID: 2874682

Clinical prediction guides

Di Giorgio A, D'Adda A, Marseglia A, Sonzogni A, Licini L, Nicastro E, D'Antiga L
Hepatol Int 2019 Jul;13(4):510-518. Epub 2019 May 8 doi: 10.1007/s12072-019-09948-1. PMID: 31069759

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...