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Thinning of Descemet membrane

MedGen UID:: 1376185
•Concept ID:: C4477011
•: Finding

HPO:	HP:0031159

Definition

A reduction in the thickness of Descemet's membrane. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThinning of Descemet membrane

Abnormality of the eye
- Abnormal eye morphology
  - Abnormal anterior eye segment morphology
    - Abnormal cornea morphology
      - Abnormal corneal endothelium morphology
        Abnormal Descemet membrane morphology
        Thinning of Descemet membrane

Conditions with this feature

Posterior polymorphous corneal dystrophy 1

MedGen UID:: 343836
•Concept ID:: C1852555
•: Disease or Syndrome

A posterior polymorphous corneal dystrophy that has material basis in autosomal dominant inheritance of mutation in the OVOL2 gene on chromosome 20p11.23.

See: Condition Record

Posterior polymorphous corneal dystrophy 1

Professional guidelines

PubMed

Infectious keratitis caused by Klebsiella spp.: predisposing factors, presentation, and management.

Masoumi A, Zeidabadinejad H, Jafari B, Esfandiari A, Soleimani M
Int Ophthalmol 2023 Apr;43(4):1169-1173. Epub 2022 Sep 17 doi: 10.1007/s10792-022-02515-y. PMID: 36114910

See all (1)

Recent clinical studies

Etiology

Surgical management of complicated Descemet's membrane detachment in corneas without prior endothelial keratoplasty.

Berger T, Seitz B, Flockerzi E, Suffo S, Flockerzi FA, Berger M, Szentmáry N, Daas L
Graefes Arch Clin Exp Ophthalmol 2024 Mar;262(3):879-889. Epub 2023 Sep 8 doi: 10.1007/s00417-023-06231-w. PMID: 37682334 Free PMC Article

Lamellar corneal patch grafts in the management of corneal thinning and perforations without using extra corneas.

Calli U, Genc S, Şalkacı O, Ömeroğlu A
Semin Ophthalmol 2022 Jan 2;37(1):3-6. Epub 2021 Apr 6 doi: 10.1080/08820538.2021.1896754. PMID: 33822683

POSTOPERATIVE THINNING OF LAMELLAR DONOR GRAFT AFTER CONVENTIONAL DESCEMET'S STRIPPING AUTOMATED ENDOTHELIAL KERATOPLASTY.

Meter A, Kuzman T, Kalauz M, Škegro I, Masnec S, Pavan J
Acta Clin Croat 2018 Dec;57(4):653-657. doi: 10.20471/acc.2018.57.04.07. PMID: 31168202 Free PMC Article

Corneal Sublayers Thickness in Patients With Mitral Valve Prolapse.

Duru N, Haşhaş OE, Göktaş E, Duru Z, Arifoğlu HB, Ulusoy DM, Karatepe Haşhaş AS, Ataş M
Eye Contact Lens 2018 Jan;44(1):55-59. doi: 10.1097/ICL.0000000000000300. PMID: 27541972

Acute corneal hydrops in keratoconus.

Maharana PK, Sharma N, Vajpayee RB
Indian J Ophthalmol 2013 Aug;61(8):461-4. doi: 10.4103/0301-4738.116062. PMID: 23925338 Free PMC Article

See all (32)

Diagnosis

Surgical management of complicated Descemet's membrane detachment in corneas without prior endothelial keratoplasty.

Congenital Corneal Opacity in 22q11.2 Deletion Syndrome: A Case Series.

Franco E, Iqbal N, Shah PR, Alabek M, Tripi KS, Prescott C, Scanga HL, Chu CT, Nischal KK
Cornea 2023 Mar 1;42(3):344-350. Epub 2022 Nov 30 doi: 10.1097/ICO.0000000000003155. PMID: 36455075

Descemet Membrane Detachment After Penetrating Keratoplasty for Keratoconus.

Kit V, Kriman J, Vasquez-Perez A, Muthusamy K, Thaung C, Tuft S
Cornea 2020 Oct;39(10):1315-1320. doi: 10.1097/ICO.0000000000002352. PMID: 32384301

Corneal Sublayers Thickness in Patients With Mitral Valve Prolapse.

Duru N, Haşhaş OE, Göktaş E, Duru Z, Arifoğlu HB, Ulusoy DM, Karatepe Haşhaş AS, Ataş M
Eye Contact Lens 2018 Jan;44(1):55-59. doi: 10.1097/ICL.0000000000000300. PMID: 27541972

Acute corneal hydrops in keratoconus.

Maharana PK, Sharma N, Vajpayee RB
Indian J Ophthalmol 2013 Aug;61(8):461-4. doi: 10.4103/0301-4738.116062. PMID: 23925338 Free PMC Article

See all (24)

Therapy

The potential therapeutic efficacy of intravenous versus subconjunctival mesenchymal stem cells on experimentally ultraviolet-induced corneal injury in adult male albino rats.

Nasr El-Din WA, Nooreldin N, Essawy AS
Folia Morphol (Warsz) 2022;81(4):900-916. Epub 2021 Sep 21 doi: 10.5603/FM.a2021.0085. PMID: 34545564

Descemet Membrane Detachment After Penetrating Keratoplasty for Keratoconus.

Kit V, Kriman J, Vasquez-Perez A, Muthusamy K, Thaung C, Tuft S
Cornea 2020 Oct;39(10):1315-1320. doi: 10.1097/ICO.0000000000002352. PMID: 32384301

Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography.

Fujita A, Yoshida J, Toyono T, Usui T, Miyai T
Curr Eye Res 2019 Nov;44(11):1189-1194. Epub 2019 Jun 13 doi: 10.1080/02713683.2019.1629597. PMID: 31172834

Atypical hydrops in keratoconus.

Said DG, Faraj L, Elalfy MS, Miri A, Maharajan SV, Dua HS
Int Ophthalmol 2014 Aug;34(4):951-5. Epub 2013 Nov 19 doi: 10.1007/s10792-013-9881-9. PMID: 24249457

Silicone oil keratopathy.

Choi WC, Choi SK, Lee JH
Korean J Ophthalmol 1993 Dec;7(2):65-9. doi: 10.3341/kjo.1993.7.2.65. PMID: 8189637

See all (13)

Prognosis

Surgical management of complicated Descemet's membrane detachment in corneas without prior endothelial keratoplasty.

Severity Assessment of Acute Hydrops Due to Recurrent Keratoconus after Penetrating Keratoplasty Using Anterior Segment Optical Coherence Tomography.

Fujita A, Yoshida J, Toyono T, Usui T, Miyai T
Curr Eye Res 2019 Nov;44(11):1189-1194. Epub 2019 Jun 13 doi: 10.1080/02713683.2019.1629597. PMID: 31172834

Corneal Sublayers Thickness in Patients With Mitral Valve Prolapse.

Duru N, Haşhaş OE, Göktaş E, Duru Z, Arifoğlu HB, Ulusoy DM, Karatepe Haşhaş AS, Ataş M
Eye Contact Lens 2018 Jan;44(1):55-59. doi: 10.1097/ICL.0000000000000300. PMID: 27541972

Atypical hydrops in keratoconus.

Said DG, Faraj L, Elalfy MS, Miri A, Maharajan SV, Dua HS
Int Ophthalmol 2014 Aug;34(4):951-5. Epub 2013 Nov 19 doi: 10.1007/s10792-013-9881-9. PMID: 24249457

Keratoconus: a review.

Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS
Cont Lens Anterior Eye 2010 Aug;33(4):157-66; quiz 205. doi: 10.1016/j.clae.2010.04.006. PMID: 20537579

See all (10)

Clinical prediction guides

Congenital Corneal Opacity in 22q11.2 Deletion Syndrome: A Case Series.

Franco E, Iqbal N, Shah PR, Alabek M, Tripi KS, Prescott C, Scanga HL, Chu CT, Nischal KK
Cornea 2023 Mar 1;42(3):344-350. Epub 2022 Nov 30 doi: 10.1097/ICO.0000000000003155. PMID: 36455075

A unique pre-endothelial layer at the posterior peripheral cornea: ultrastructural study.

Akhtar S, Samivel R, Smedowski A, Alkanaan A, Masmali A, Kirat O, Khan AA, Almubrad T
Sci Rep 2022 Feb 15;12(1):2556. doi: 10.1038/s41598-022-06552-6. PMID: 35169268 Free PMC Article

The potential therapeutic efficacy of intravenous versus subconjunctival mesenchymal stem cells on experimentally ultraviolet-induced corneal injury in adult male albino rats.

Nasr El-Din WA, Nooreldin N, Essawy AS
Folia Morphol (Warsz) 2022;81(4):900-916. Epub 2021 Sep 21 doi: 10.5603/FM.a2021.0085. PMID: 34545564

An in depth analysis of histopathological characteristics found in keratoconus.

Sykakis E, Carley F, Irion L, Denton J, Hillarby MC
Pathology 2012 Apr;44(3):234-9. doi: 10.1097/PAT.0b013e3283511b42. PMID: 22406479

Keratoconus: a review.

Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS
Cont Lens Anterior Eye 2010 Aug;33(4):157-66; quiz 205. doi: 10.1016/j.clae.2010.04.006. PMID: 20537579

See all (20)

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Thinning of Descemet membrane

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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