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Increased CSF/serum albumin ratio

MedGen UID:
1375860
Concept ID:
C4476791
Finding
HPO: HP:0025459

Definition

An increase above normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Libri I, Silvestri C, Caratozzolo S, Alberici A, Pilotto A, Archetti S, Trainini L, Borroni B, Padovani A, Benussi A
Neurobiol Aging 2024 Aug;140:33-40. Epub 2024 Apr 10 doi: 10.1016/j.neurobiolaging.2024.04.003. PMID: 38718740
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440

Recent clinical studies

Etiology

Engel S, Halcour J, Ellwardt E, Uphaus T, Steffen F, Zipp F, Bittner S, Luessi F
Fluids Barriers CNS 2023 Jan 11;20(1):3. doi: 10.1186/s12987-022-00403-2. PMID: 36631830Free PMC Article
Lai QL, Cai MT, Zheng Y, Fang GL, Du BQ, Shen CH, Wang JJ, Weng QJ, Zhang YX
Fluids Barriers CNS 2022 Nov 23;19(1):93. doi: 10.1186/s12987-022-00392-2. PMID: 36419157Free PMC Article
Jeppesen R, Orlovska-Waast S, Sørensen NV, Christensen RHB, Benros ME
Schizophr Bull 2022 Nov 18;48(6):1206-1216. doi: 10.1093/schbul/sbac098. PMID: 35939296Free PMC Article
Lin Z, Sur S, Liu P, Li Y, Jiang D, Hou X, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Albert M, Moghekar A, Lu H
Ann Neurol 2021 Aug;90(2):227-238. Epub 2021 Jun 5 doi: 10.1002/ana.26134. PMID: 34041783Free PMC Article
Llorens F, Schmitz M, Gloeckner SF, Kaerst L, Hermann P, Schmidt C, Varges D, Zerr I
J Neurol Sci 2015 Nov 15;358(1-2):398-403. Epub 2015 Oct 23 doi: 10.1016/j.jns.2015.10.011. PMID: 26476775

Diagnosis

Jeppesen R, Borbye-Lorenzen N, Christensen RHB, Sørensen NV, Köhler-Forsberg O, Skogstrand K, Benros ME
Brain Behav Immun 2024 Mar;117:167-174. Epub 2023 Dec 29 doi: 10.1016/j.bbi.2023.12.035. PMID: 38160934
Verde F, Milone I, Colombo E, Maranzano A, Dubini A, Colombrita C, Gentile F, Doretti A, Torre S, Messina S, Morelli C, Torresani E, Poletti B, Priori A, Maderna L, Ratti A, Silani V, Ticozzi N
Neurol Sci 2023 Oct;44(10):3697-3702. Epub 2023 Jun 27 doi: 10.1007/s10072-023-06916-4. PMID: 37369876
Shams M, Martola J, Charidimou A, Granberg T, Ferreira D, Westman E, Wintermark M, Iv M, Larvie M, Kristoffersen Wiberg M, Kaijser M, Forsgard N, Zetterberg H, Wahlund LO, Shams S
J Alzheimers Dis 2020;78(3):1229-1236. doi: 10.3233/JAD-200656. PMID: 33104030
Parnetti L, Paciotti S, Farotti L, Bellomo G, Sepe FN, Eusebi P
Clin Chim Acta 2019 Aug;495:318-325. Epub 2019 Apr 30 doi: 10.1016/j.cca.2019.04.078. PMID: 31051162
Llorens F, Schmitz M, Gloeckner SF, Kaerst L, Hermann P, Schmidt C, Varges D, Zerr I
J Neurol Sci 2015 Nov 15;358(1-2):398-403. Epub 2015 Oct 23 doi: 10.1016/j.jns.2015.10.011. PMID: 26476775

Therapy

Brown RB, Tozer DJ, Loubière L, Harshfield EL, Hong YT, Fryer TD, Williams GB, Graves MJ, Aigbirhio FI, O'Brien JT, Markus HS
Alzheimers Dement 2024 Jun;20(6):3852-3863. Epub 2024 Apr 17 doi: 10.1002/alz.13830. PMID: 38629936Free PMC Article
Danielson M, Wiklund A, Granath F, Blennow K, Mkrtchian S, Nellgård B, Oras J, Jonsson Fagerlund M, Granström A, Schening A, Rasmussen LS, Erlandsson Harris H, Zetterberg H, Ricksten SE, Eriksson LI
Ann Neurol 2020 Mar;87(3):370-382. Epub 2020 Jan 25 doi: 10.1002/ana.25678. PMID: 31930549
Danielson M, Reinsfelt B, Westerlind A, Zetterberg H, Blennow K, Ricksten SE
J Neuroinflammation 2018 Sep 27;15(1):283. doi: 10.1186/s12974-018-1318-y. PMID: 30261896Free PMC Article
Sartorius T, Peter A, Heni M, Maetzler W, Fritsche A, Häring HU, Hennige AM
PLoS One 2015;10(5):e0126804. Epub 2015 May 12 doi: 10.1371/journal.pone.0126804. PMID: 25965336Free PMC Article
Anckarsäter R, Anckarsäter H, Bromander S, Blennow K, Wass C, Zetterberg H
J Neural Transm (Vienna) 2014 Jun;121(6):649-53. Epub 2014 Jan 14 doi: 10.1007/s00702-013-1156-0. PMID: 24420082

Prognosis

Lai QL, Cai MT, Zheng Y, Fang GL, Du BQ, Shen CH, Wang JJ, Weng QJ, Zhang YX
Fluids Barriers CNS 2022 Nov 23;19(1):93. doi: 10.1186/s12987-022-00392-2. PMID: 36419157Free PMC Article
Lin Z, Sur S, Liu P, Li Y, Jiang D, Hou X, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Albert M, Moghekar A, Lu H
Ann Neurol 2021 Aug;90(2):227-238. Epub 2021 Jun 5 doi: 10.1002/ana.26134. PMID: 34041783Free PMC Article
Garland P, Morton M, Zolnourian A, Durnford A, Gaastra B, Toombs J, Heslegrave AJ, More J, Zetterberg H, Bulters DO, Galea I
Brain 2021 Apr 12;144(3):761-768. doi: 10.1093/brain/awaa451. PMID: 33517369Free PMC Article
Parnetti L, Paciotti S, Farotti L, Bellomo G, Sepe FN, Eusebi P
Clin Chim Acta 2019 Aug;495:318-325. Epub 2019 Apr 30 doi: 10.1016/j.cca.2019.04.078. PMID: 31051162
Elwood E, Lim Z, Naveed H, Galea I
Brain Behav Immun 2017 May;62:35-40. Epub 2016 Nov 1 doi: 10.1016/j.bbi.2016.10.020. PMID: 27810376Free PMC Article

Clinical prediction guides

Engel S, Halcour J, Ellwardt E, Uphaus T, Steffen F, Zipp F, Bittner S, Luessi F
Fluids Barriers CNS 2023 Jan 11;20(1):3. doi: 10.1186/s12987-022-00403-2. PMID: 36631830Free PMC Article
Lai QL, Cai MT, Zheng Y, Fang GL, Du BQ, Shen CH, Wang JJ, Weng QJ, Zhang YX
Fluids Barriers CNS 2022 Nov 23;19(1):93. doi: 10.1186/s12987-022-00392-2. PMID: 36419157Free PMC Article
Lin Z, Sur S, Liu P, Li Y, Jiang D, Hou X, Darrow J, Pillai JJ, Yasar S, Rosenberg P, Albert M, Moghekar A, Lu H
Ann Neurol 2021 Aug;90(2):227-238. Epub 2021 Jun 5 doi: 10.1002/ana.26134. PMID: 34041783Free PMC Article
Garland P, Morton M, Zolnourian A, Durnford A, Gaastra B, Toombs J, Heslegrave AJ, More J, Zetterberg H, Bulters DO, Galea I
Brain 2021 Apr 12;144(3):761-768. doi: 10.1093/brain/awaa451. PMID: 33517369Free PMC Article
Parnetti L, Paciotti S, Farotti L, Bellomo G, Sepe FN, Eusebi P
Clin Chim Acta 2019 Aug;495:318-325. Epub 2019 Apr 30 doi: 10.1016/j.cca.2019.04.078. PMID: 31051162

Recent systematic reviews

Orlovska-Waast S, Köhler-Forsberg O, Brix SW, Nordentoft M, Kondziella D, Krogh J, Benros ME
Mol Psychiatry 2019 Jun;24(6):869-887. Epub 2018 Aug 16 doi: 10.1038/s41380-018-0220-4. PMID: 30116031Free PMC Article

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