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Multinodular and vacuolating neuronal tumor

MedGen UID:
1372723
Concept ID:
C4330721
Neoplastic Process
Synonyms: Multinodular and Vacuolated Neuronal Tumor; Multinodular and Vacuolated Neuronal Tumor of the Cerebrum; Multinodular and Vacuolated Tumor of the Cerebrum; Multinodular and Vacuolating Neuronal Tumor; multinodular and vacuolating neuronal tumor
 
Monarch Initiative: MONDO:0858957

Definition

A low-grade tumor affecting the cerebral hemispheres. It is composed of cells with glial and/or neuronal differentiation forming multiple nodules with prominent vacuolation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultinodular and vacuolating neuronal tumor

Recent clinical studies

Etiology

Turan A, Tatar IG, Hekimoglu A, Coskun H, Yildirim F
Turk Neurosurg 2021;31(5):725-730. doi: 10.5137/1019-5149.JTN.32215-20.3. PMID: 34169991
Nunes Dias L, Candela-Cantó S, Jou C, Aparicio Calvo J, García-García S, Mena-Bernal JH
Childs Nerv Syst 2020 Jul;36(7):1557-1561. Epub 2020 Jan 16 doi: 10.1007/s00381-019-04496-3. PMID: 31950248
Buffa GB, Chaves H, Serra MM, Stefanoff NI, Gagliardo AS, Yañez P
J Neuroradiol 2020 May;47(3):216-220. Epub 2019 Jun 20 doi: 10.1016/j.neurad.2019.05.010. PMID: 31229580
Lecler A, Bailleux J, Carsin B, Adle-Biassette H, Baloglu S, Bogey C, Bonneville F, Calvier E, Comby PO, Cottier JP, Cotton F, Deschamps R, Diard-Detoeuf C, Ducray F, Duron L, Drissi C, Elmaleh M, Farras J, Garcia JA, Gerardin E, Grand S, Jianu DC, Kremer S, Magne N, Mejdoubi M, Moulignier A, Ollivier M, Nagi S, Rodallec M, Sadik JC, Shor N, Tourdias T, Vandendries C, Broquet V, Savatovsky J; ENIGMA Investigation Group (EuropeaN Interdisciplinary Group for MVNT Analysis)
AJNR Am J Neuroradiol 2019 Oct;40(10):1689-1694. Epub 2019 Sep 26 doi: 10.3174/ajnr.A6223. PMID: 31558497Free PMC Article
Thom M, Liu J, Bongaarts A, Reinten RJ, Paradiso B, Jäger HR, Reeves C, Somani A, An S, Marsdon D, McEvoy A, Miserocchi A, Thorne L, Newman F, Bucur S, Honavar M, Jacques T, Aronica E
Brain Pathol 2018 Mar;28(2):155-171. Epub 2017 Sep 19 doi: 10.1111/bpa.12555. PMID: 28833756Free PMC Article

Diagnosis

Lim SD, Kim SI, Park JW, Won JK, Kim SK, Phi JH, Chung CK, Choi SH, Yun H, Park SH
Brain Tumor Pathol 2022 Apr;39(2):65-78. Epub 2022 Jan 20 doi: 10.1007/s10014-021-00420-3. PMID: 35048219
Alizada O, Ayman T, Akgun MY, Sar M, Urganci N, Kemerdere R
Clin Neurol Neurosurg 2020 Oct;197:106149. Epub 2020 Aug 11 doi: 10.1016/j.clineuro.2020.106149. PMID: 32979644
Lecler A, Broquet V, Bailleux J, Carsin B, Adle-Biassette H, Baloglu S, Forestier G, Bonneville F, Calvier E, Chauvet D, Comby PO, Cottier JP, Cotton F, Deschamps R, Diard-Detoeuf C, Ducray F, Drissi C, Elmaleh M, Farras J, Aguilar Garcia J, Gerardin E, Grand S, Jianu DC, Kremer S, Loiseau H, Magne N, Mejdoubi M, Moulignier A, Ollivier M, Nagi S, Rodallec M, Shor N, Tourdias T, Vandendries C, Anxionnat R, Duron L, Savatovsky J
Eur J Neurol 2020 Aug;27(8):1561-1569. Epub 2020 May 22 doi: 10.1111/ene.14264. PMID: 32301260
Buffa GB, Chaves H, Serra MM, Stefanoff NI, Gagliardo AS, Yañez P
J Neuroradiol 2020 May;47(3):216-220. Epub 2019 Jun 20 doi: 10.1016/j.neurad.2019.05.010. PMID: 31229580
Gonzalez-Quarante LH, Ruiz-Juretschke F, Sola Vendrell E, Gil de Sagredo Del Corral OL, Agarwal V, Garcia-Leal R
Neurocirugia (Astur : Engl Ed) 2018 Jan-Feb;29(1):44-55. Epub 2017 Oct 28 doi: 10.1016/j.neucir.2017.08.003. PMID: 29111096

Prognosis

Zhang W, Guo Q, Chen J, Zhu D, Tan Q, Zhang L, Li H, Cheng B
Eur J Med Res 2024 Oct 24;29(1):512. doi: 10.1186/s40001-024-02097-8. PMID: 39444045Free PMC Article
Nunes Dias L, Candela-Cantó S, Jou C, Aparicio Calvo J, García-García S, Mena-Bernal JH
Childs Nerv Syst 2020 Jul;36(7):1557-1561. Epub 2020 Jan 16 doi: 10.1007/s00381-019-04496-3. PMID: 31950248
De Wandeler T, De Brucker Y, Jansen A, Vanderhasselt T
Acta Neurol Belg 2020 Jun;120(3):747-748. Epub 2019 Jun 14 doi: 10.1007/s13760-019-01157-9. PMID: 31201671
Alsufayan R, Alcaide-Leon P, de Tilly LN, Mandell DM, Krings T
Neuroradiology 2017 Sep;59(9):873-883. Epub 2017 Jul 27 doi: 10.1007/s00234-017-1884-1. PMID: 28752311

Clinical prediction guides

Buffa GB, Chaves H, Serra MM, Stefanoff NI, Gagliardo AS, Yañez P
J Neuroradiol 2020 May;47(3):216-220. Epub 2019 Jun 20 doi: 10.1016/j.neurad.2019.05.010. PMID: 31229580
Thom M, Liu J, Bongaarts A, Reinten RJ, Paradiso B, Jäger HR, Reeves C, Somani A, An S, Marsdon D, McEvoy A, Miserocchi A, Thorne L, Newman F, Bucur S, Honavar M, Jacques T, Aronica E
Brain Pathol 2018 Mar;28(2):155-171. Epub 2017 Sep 19 doi: 10.1111/bpa.12555. PMID: 28833756Free PMC Article

Recent systematic reviews

On TJ, Alcantar-Garibay O, Xu Y, Abramov I, Eschbacher JM, Tiwari N, Smith KA, Preul MC
Acta Neurochir (Wien) 2024 Aug 19;166(1):340. doi: 10.1007/s00701-024-06230-8. PMID: 39160266

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