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Idiopathic acute eosinophilic pneumonia

MedGen UID:
1371970
•Concept ID:
C4518469
•
Disease or Syndrome
Synonyms: Acute Eosinophilic Pneumonia; IAEP; idiopathic acute eosinophilic pneumonia; Loeffler syndrome; Loeffler's pneumonia; Loffler syndrome; Loffler's syndrome; Löffler syndrome; pulmonary infiltrates with eosinophilia
SNOMED CT: Idiopathic acute eosinophilic pneumonia (724499007)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0019122
Orphanet: ORPHA724

Definition

Idiopathic acute eosinophilic pneumonia (IAEP) is an eosinophilic pneumonia of undetermined etiology that is characterized by acute febrile hypoxic respiratory failure associated with diffuse radiographic infiltrates and pulmonary eosinophilia, but without concurring allergy or infection. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic acute eosinophilic pneumonia

Professional guidelines

PubMed

Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396

Recent clinical studies

Etiology

Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature.
Harne PS, Rao S, Malik M, Shepherd Z
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925978. doi: 10.1177/2324709620925978. PMID: 32462944Free PMC Article
Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use.
Mull ES, Erdem G, Nicol K, Adler B, Shell R
Pediatrics 2020 Apr;145(4) doi: 10.1542/peds.2019-3007. PMID: 32217740
Idiopathic acute eosinophilic pneumonia: A rare cause of hypoxic respiratory failure.
Spaulding KH, Ng PC, April MD
Am J Emerg Med 2019 Dec;37(12):2264.e1-2264.e3. Epub 2019 Aug 5 doi: 10.1016/j.ajem.2019.158386. PMID: 31427164
Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396
Idiopathic acute eosinophilic pneumonia: a study of 22 patients.
Philit F, Etienne-Mastroïanni B, Parrot A, Guérin C, Robert D, Cordier JF
Am J Respir Crit Care Med 2002 Nov 1;166(9):1235-9. doi: 10.1164/rccm.2112056. PMID: 12403693

Diagnosis

Eosinophilic Lung Diseases.
Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Idiopathic acute eosinophilic pneumonia.
Pizzuto M, Seychell M, Caruana Montaldo B, Mizzi A
BMJ Case Rep 2019 Sep 26;12(9) doi: 10.1136/bcr-2019-231095. PMID: 31558489Free PMC Article
Eosinophilic Lung Diseases.
Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599
Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396
Eosinophilic lung diseases.
Cottin V, Cordier JF
Immunol Allergy Clin North Am 2012 Nov;32(4):557-86. doi: 10.1016/j.iac.2012.08.007. PMID: 23102066

Therapy

Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature.
Harne PS, Rao S, Malik M, Shepherd Z
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925978. doi: 10.1177/2324709620925978. PMID: 32462944Free PMC Article
Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use.
Mull ES, Erdem G, Nicol K, Adler B, Shell R
Pediatrics 2020 Apr;145(4) doi: 10.1542/peds.2019-3007. PMID: 32217740
Idiopathic acute eosinophilic pneumonia.
Pizzuto M, Seychell M, Caruana Montaldo B, Mizzi A
BMJ Case Rep 2019 Sep 26;12(9) doi: 10.1136/bcr-2019-231095. PMID: 31558489Free PMC Article
Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396
Idiopathic acute eosinophilic pneumonia.
Nishio M, Ohata M, Suruda T, Uetani K, Kobayashi H, Funasako M
Intern Med 1992 Sep;31(9):1139-43. doi: 10.2169/internalmedicine.31.1139. PMID: 1421726

Prognosis

Acute Eosinophilic Pneumonia Secondary to Menthol Cigarette Use: A Rare Phenomenon With a Review of Literature.
Harne PS, Rao S, Malik M, Shepherd Z
J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925978. doi: 10.1177/2324709620925978. PMID: 32462944Free PMC Article
Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment.
Giovannini-Chami L, Blanc S, Hadchouel A, Baruchel A, Boukari R, Dubus JC, Fayon M, Le Bourgeois M, Nathan N, Albertini M, Clément A, de Blic J
Pediatr Pulmonol 2016 Feb;51(2):203-16. Epub 2015 Dec 30 doi: 10.1002/ppul.23368. PMID: 26716396
Idiopathic acute eosinophilic pneumonia.
Liu KT, Wu MH, Chiu CH, Tung SM, Wu YJ, Chang SC
J Chin Med Assoc 2006 Jul;69(7):330-3. doi: 10.1016/S1726-4901(09)70268-0. PMID: 16903648
Fatal idiopathic acute eosinophilic pneumonia with acute lung injury.
Kawayama T, Fujiki R, Morimitsu Y, Rikimaru T, Aizawa H
Respirology 2002 Dec;7(4):373-5. doi: 10.1046/j.1440-1843.2002.00413.x. PMID: 12421248
Acute eosinophilic pneumonia simulating severe community acquired pneumonia.
BaHammam AS
Saudi Med J 2002 Jan;23(1):104-8. PMID: 11938376

Clinical prediction guides

Idiopathic acute eosinophilic pneumonia requiring ECMO in a teenager smoking tobacco and cannabis.
Sauvaget E, Dellamonica J, Arlaud K, Sanfiorenzo C, Bernardin G, Padovani B, Viard L, Dubus JC
Pediatr Pulmonol 2010 Dec;45(12):1246-9. Epub 2010 Sep 1 doi: 10.1002/ppul.21314. PMID: 20812251
Fatal idiopathic acute eosinophilic pneumonia with acute lung injury.
Kawayama T, Fujiki R, Morimitsu Y, Rikimaru T, Aizawa H
Respirology 2002 Dec;7(4):373-5. doi: 10.1046/j.1440-1843.2002.00413.x. PMID: 12421248

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