U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal QRS complex

MedGen UID:
1370423
Concept ID:
C4476580
Finding
HPO: HP:0025074

Definition

An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal QRS complex

Conditions with this feature

Sinoatrial node dysfunction and deafness
MedGen UID:
766932
Concept ID:
C3554018
Disease or Syndrome
Patients with sinoatrial node dysfunction and deafness have congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia (Baig et al., 2011). See Jervell and Lange-Nielsen syndrome (220400) for discussion of another deafness syndrome with impaired cardiac conduction.
Sick sinus syndrome 4
MedGen UID:
1794159
Concept ID:
C5561949
Disease or Syndrome
Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).

Professional guidelines

PubMed

Wu PE, Juurlink DN
Can J Cardiol 2022 Sep;38(9):1378-1383. Epub 2022 Apr 14 doi: 10.1016/j.cjca.2022.04.005. PMID: 35430193
Littmann L, Olson EG, Gibbs MA
Am J Emerg Med 2019 Jul;37(7):1340-1345. Epub 2019 Apr 12 doi: 10.1016/j.ajem.2019.04.027. PMID: 31027937
Hanna EB, Glancy DL
Cleve Clin J Med 2015 Jun;82(6):373-84. doi: 10.3949/ccjm.82a.14026. PMID: 26086496

Recent clinical studies

Etiology

Mukhopadhyay SK, Krishnan S
Comput Methods Programs Biomed 2022 Jan;213:106518. Epub 2021 Nov 11 doi: 10.1016/j.cmpb.2021.106518. PMID: 34808531
Sletten J, Kessler J
Acta Obstet Gynecol Scand 2015 Oct;94(10):1128-35. Epub 2015 Aug 4 doi: 10.1111/aogs.12709. PMID: 26178868
Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505

Diagnosis

Chen-Scarabelli C, Scarabelli TM
Am J Emerg Med 2009 Sep;27(7):898.e1-4. doi: 10.1016/j.ajem.2008.10.037. PMID: 19683128
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505
Zipes DP, Fisch C
Arch Intern Med 1972 Jul;130(1):129-34. PMID: 5035977
Zipes DP, Fisch C
Arch Intern Med 1972 Nov;130(5):781-4. PMID: 4117270
SEIDEN GE, KEISMAN RA
Am Heart J 1956 Jul;52(1):62-9. doi: 10.1016/0002-8703(56)90118-1. PMID: 13326835

Therapy

Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563

Prognosis

Dhesi S, Lockwood E, Sandhu RK
Can J Cardiol 2017 Aug;33(8):1060-1065. Epub 2017 Apr 23 doi: 10.1016/j.cjca.2017.04.007. PMID: 28666618
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505

Clinical prediction guides

Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563
Ker J, Webb EC, Ker JA, Bekker PA
Onderstepoort J Vet Res 2003 Dec;70(4):299-305. doi: 10.4102/ojvr.v70i4.294. PMID: 14971732

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...