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Endometrial clear cell adenocarcinoma

MedGen UID:
124655
•Concept ID:
C0279765
•
Neoplastic Process
Synonyms: Clear Cell Carcinoma of Endometrium; clear cell carcinoma of endometrium; Clear Cell Carcinoma of the Endometrium; clear cell carcinoma of the endometrium; Endometrial Clear Cell Adenocarcinoma; endometrial clear cell adenocarcinoma; endometrium clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0006191

Definition

A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing. The neoplastic cells form papillary, glandular, or sheet-like structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial clear cell adenocarcinoma

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Sentinel lymph node mapping and staging in endometrial cancer: A Society of Gynecologic Oncology literature review with consensus recommendations.
Holloway RW, Abu-Rustum NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, Rossi EC, Tanner EJ, Wolsky RJ
Gynecol Oncol 2017 Aug;146(2):405-415. Epub 2017 May 28 doi: 10.1016/j.ygyno.2017.05.027. PMID: 28566221Free PMC Article

Recent clinical studies

Etiology

Clear cell adenocarcinoma present exclusively within endometrial polyp: report of two cases.
Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2014;7(4):1757-63. Epub 2014 Mar 15 PMID: 24817975Free PMC Article
Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report.
Patsner B
Eur J Gynaecol Oncol 1998;19(6):522-3. PMID: 10215432

Diagnosis

An Isolated Metastasis From Clear Cell Renal Cell Carcinoma to the Uterus: A Case Report and Review of Literature.
Singh K, DiSilvestro PA, Lawrence WD, Quddus MR
Int J Gynecol Pathol 2016 Sep;35(5):419-22. doi: 10.1097/PGP.0000000000000253. PMID: 26630224
Clear cell adenocarcinoma present exclusively within endometrial polyp: report of two cases.
Ishida M, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2014;7(4):1757-63. Epub 2014 Mar 15 PMID: 24817975Free PMC Article
Endometrial clear cell adenocarcinoma diagnosed by endometrial cytological examination: two cases report.
Kinoshita Y, Takasu K, Adachi Y, Yuri T, Ikuta A, Shikata N
Diagn Cytopathol 2011 Mar;39(3):200-3. doi: 10.1002/dc.21397. PMID: 21319323
Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report.
Patsner B
Eur J Gynaecol Oncol 1998;19(6):522-3. PMID: 10215432
Characterization of a newly established human tumor cell line (TEN) from a patient with clear cell carcinoma of the uterine body and its sensitivity to anti-cancer agents.
Fushiki H, Hidaka T, Fujimura M, Yasoshima K, Yamakawa Y, Izumi R
Hum Cell 1997 Sep;10(3):199-208. PMID: 9436040

Therapy

Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report.
Patsner B
Eur J Gynaecol Oncol 1998;19(6):522-3. PMID: 10215432

Prognosis

Endometrial clear cell adenocarcinoma diagnosed by endometrial cytological examination: two cases report.
Kinoshita Y, Takasu K, Adachi Y, Yuri T, Ikuta A, Shikata N
Diagn Cytopathol 2011 Mar;39(3):200-3. doi: 10.1002/dc.21397. PMID: 21319323
Late recurrence of a uterine clear cell adenocarcinoma confined to an endometrial polyp: case report.
Patsner B
Eur J Gynaecol Oncol 1998;19(6):522-3. PMID: 10215432

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