U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nasal flaring

MedGen UID:
124453
•Concept ID:
C0277873
•
Sign or Symptom
Synonyms: Flared alae nasi; Flaring nostrils; Flaring of nasal alae
SNOMED CT: Alar flare, nose (21558008); Flared nostrils (21558008); Flaring of alae nasi (21558008); Nasal flaring (248568003)
 
HPO: HP:0030863

Definition

Widening of the nostrils upon inhalation as a manifestation of respiratory distress. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasal flaring

Conditions with this feature

Ectodermal dysplasia-blindness syndrome
MedGen UID:
340297
•Concept ID:
C1849332
•
Disease or Syndrome
A rare multiple congenital anomalies/dysmorphic syndrome characterized by intellectual disability, severe visual impairment due to ocular malformations (microphthalmos and microcornea with sclerocornea), short stature, hypotrichosis, dental anomalies, and dysmorphic facial features (such as a narrow nasal bridge with marked distal flaring and low-set, protruding ears). There have been no further descriptions in the literature since 1992.
See: Condition Record
Alfadhel syndrome
MedGen UID:
1845825
•Concept ID:
C5882735
•
Disease or Syndrome
Alfadhel syndrome (AFDL) is an autosomal recessive neurodevelopmental disorder with features of global developmental delay, hypotonia, and facial dysmorphism (Asiri et al., 2020, Bertoli-Avella et al., 2021).
See: Condition Record
Alfadhel syndrome
Ectodermal dysplasia-blindness syndrome

Professional guidelines

PubMed

International variation in evidence-based emergency department management of bronchiolitis: a retrospective cohort study.
Lirette MP, Kuppermann N, Finkelstein Y, Zemek R, Plint AC, Florin TA, Babl FE, Dalziel S, Freedman S, Roland D, Lyttle MD, Schnadower D, Steele D, Fernandes RM, Stephens D, Kharbanda A, Johnson DW, Macias C, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
BMJ Open 2022 Dec 7;12(12):e059784. doi: 10.1136/bmjopen-2021-059784. PMID: 36600373Free PMC Article
Community-acquired pneumonia among children: the latest evidence for an updated management.
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Optimising the management of bronchiolitis in infants.
McNaughten B, Bourke TW
Practitioner 2015 Jul-Aug;259(1784):13-5, 2. PMID: 26514055

Recent clinical studies

Etiology

Nasal flaring as a clinical sign of respiratory acidosis in patients with dyspnea.
Zorrilla-Riveiro JG, Arnau-Bartés A, Rafat-Sellarés R, García-Pérez D, Mas-Serra A, Fernández-Fernández R
Am J Emerg Med 2017 Apr;35(4):548-553. Epub 2016 Dec 10 doi: 10.1016/j.ajem.2016.12.008. PMID: 28007319
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Chest physiotherapy for pneumonia in children.
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988
Sleep-disordered breathing in children.
Guilleminault C, Pelayo R
Ann Med 1998 Aug;30(4):350-6. doi: 10.3109/07853899809029934. PMID: 9783833
Alae nasi activation (nasal flaring) decreases nasal resistance in preterm infants.
Carlo WA, Martin RJ, Bruce EN, Strohl KP, Fanaroff AA
Pediatrics 1983 Sep;72(3):338-43. PMID: 6684277

Diagnosis

International variation in evidence-based emergency department management of bronchiolitis: a retrospective cohort study.
Lirette MP, Kuppermann N, Finkelstein Y, Zemek R, Plint AC, Florin TA, Babl FE, Dalziel S, Freedman S, Roland D, Lyttle MD, Schnadower D, Steele D, Fernandes RM, Stephens D, Kharbanda A, Johnson DW, Macias C, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
BMJ Open 2022 Dec 7;12(12):e059784. doi: 10.1136/bmjopen-2021-059784. PMID: 36600373Free PMC Article
Community-acquired pneumonia among children: the latest evidence for an updated management.
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Newborn Respiratory Distress.
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Sleep-disordered breathing in children.
Guilleminault C, Pelayo R
Ann Med 1998 Aug;30(4):350-6. doi: 10.3109/07853899809029934. PMID: 9783833

Therapy

Community-acquired pneumonia among children: the latest evidence for an updated management.
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
ICU Clinicians Underestimate Breathing Discomfort in Ventilated Subjects.
Binks AP, Desjardin S, Riker R
Respir Care 2017 Feb;62(2):150-155. Epub 2016 Dec 13 doi: 10.4187/respcare.04927. PMID: 27965421
Newborn Respiratory Distress.
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Chest physiotherapy for pneumonia in children.
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

Prognosis

Community-acquired pneumonia among children: the latest evidence for an updated management.
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
Predicting Escalated Care in Infants With Bronchiolitis.
Freire G, Kuppermann N, Zemek R, Plint AC, Babl FE, Dalziel SR, Freedman SB, Atenafu EG, Stephens D, Steele DW, Fernandes RM, Florin TA, Kharbanda A, Lyttle MD, Johnson DW, Schnadower D, Macias CG, Benito J, Schuh S; Pediatric Emergency Research Networks (PERN)
Pediatrics 2018 Sep;142(3) Epub 2018 Aug 20 doi: 10.1542/peds.2017-4253. PMID: 30126934
Practice Variation in Acute Bronchiolitis: A Pediatric Emergency Research Networks Study.
Schuh S, Babl FE, Dalziel SR, Freedman SB, Macias CG, Stephens D, Steele DW, Fernandes RM, Zemek R, Plint AC, Florin TA, Lyttle MD, Johnson DW, Gouin S, Schnadower D, Klassen TP, Bajaj L, Benito J, Kharbanda A, Kuppermann N; Pediatric Emergency Research Networks (PERN)
Pediatrics 2017 Dec;140(6) doi: 10.1542/peds.2017-0842. PMID: 29184035
Clinical features for diagnosis of pneumonia in children younger than 5 years: a systematic review and meta-analysis.
Rambaud-Althaus C, Althaus F, Genton B, D'Acremont V
Lancet Infect Dis 2015 Apr;15(4):439-50. Epub 2015 Mar 11 doi: 10.1016/S1473-3099(15)70017-4. PMID: 25769269
Clinical signs of hypoxaemia in children with acute lower respiratory infection: indicators of oxygen therapy.
Usen S, Webert M
Int J Tuberc Lung Dis 2001 Jun;5(6):505-10. PMID: 11409575

Clinical prediction guides

Respiratory Distress and it's Clinical Outcome in Tertiary Care Centre.
Chaitanya, Ravikiran
J Assoc Physicians India 2022 Apr;70(4):11-12. PMID: 35443455
Community-acquired pneumonia among children: the latest evidence for an updated management.
Nascimento-Carvalho CM
J Pediatr (Rio J) 2020 Mar-Apr;96 Suppl 1(Suppl 1):29-38. Epub 2019 Sep 10 doi: 10.1016/j.jped.2019.08.003. PMID: 31518547Free PMC Article
The complexities of nasal airflow: theory and practice.
O'Neill G, Tolley NS
J Appl Physiol (1985) 2019 Nov 1;127(5):1215-1223. Epub 2019 Aug 1 doi: 10.1152/japplphysiol.01118.2018. PMID: 31369336
Nasal flaring as a clinical sign of respiratory acidosis in patients with dyspnea.
Zorrilla-Riveiro JG, Arnau-Bartés A, Rafat-Sellarés R, García-Pérez D, Mas-Serra A, Fernández-Fernández R
Am J Emerg Med 2017 Apr;35(4):548-553. Epub 2016 Dec 10 doi: 10.1016/j.ajem.2016.12.008. PMID: 28007319
Chest physiotherapy for pneumonia in children.
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

Recent systematic reviews

Clinical features for diagnosis of pneumonia in children younger than 5 years: a systematic review and meta-analysis.
Rambaud-Althaus C, Althaus F, Genton B, D'Acremont V
Lancet Infect Dis 2015 Apr;15(4):439-50. Epub 2015 Mar 11 doi: 10.1016/S1473-3099(15)70017-4. PMID: 25769269
Chest physiotherapy for pneumonia in children.
Chaves GS, Fregonezi GA, Dias FA, Ribeiro CT, Guerra RO, Freitas DA, Parreira VF, Mendonca KM
Cochrane Database Syst Rev 2013 Sep 20;(9):CD010277. doi: 10.1002/14651858.CD010277.pub2. PMID: 24057988

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...