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Invasive pulmonary aspergillosis

MedGen UID:
124444
•Concept ID:
C0276653
•
Disease or Syndrome
Synonyms: Aspergillosis, Invasive Pulmonary; Invasive Pulmonary Aspergillosis; Pulmonary Aspergilloses, Invasive; Pulmonary Aspergillosis - Invasive; Pulmonary Aspergillosis Invasive; Pulmonary Aspergillosis, Invasive
SNOMED CT: Invasive pulmonary aspergillosis (3214003)
 
HPO: HP:0020103

Definition

Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive pulmonary aspergillosis

Professional guidelines

PubMed

Pulmonary aspergillosis: diagnosis and treatment.
Lamoth F, Calandra T
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 29 doi: 10.1183/16000617.0114-2022. PMID: 36450372Free PMC Article
Aspergillosis: Epidemiology, Diagnosis, and Treatment.
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Etiology

Acute Invasive Pulmonary Aspergillosis: Clinical Presentation and Treatment.
Heylen J, Vanbiervliet Y, Maertens J, Rijnders B, Wauters J
Semin Respir Crit Care Med 2024 Feb;45(1):69-87. Epub 2024 Jan 11 doi: 10.1055/s-0043-1777769. PMID: 38211628
Aspergillosis: Epidemiology, Diagnosis, and Treatment.
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Invasive Pulmonary Aspergillosis.
Ledoux MP, Guffroy B, Nivoix Y, Simand C, Herbrecht R
Semin Respir Crit Care Med 2020 Feb;41(1):80-98. Epub 2020 Jan 30 doi: 10.1055/s-0039-3401990. PMID: 32000286
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, Ullmann AJ, Dimopoulos G, Lange C; European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society
Eur Respir J 2016 Jan;47(1):45-68. doi: 10.1183/13993003.00583-2015. PMID: 26699723

Diagnosis

Aspergillosis: Epidemiology, Diagnosis, and Treatment.
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches.
Jenks JD, Nam HH, Hoenigl M
Mycoses 2021 Sep;64(9):1002-1014. Epub 2021 Apr 6 doi: 10.1111/myc.13274. PMID: 33760284Free PMC Article
Invasive Pulmonary Aspergillosis.
Ledoux MP, Guffroy B, Nivoix Y, Simand C, Herbrecht R
Semin Respir Crit Care Med 2020 Feb;41(1):80-98. Epub 2020 Jan 30 doi: 10.1055/s-0039-3401990. PMID: 32000286
Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes.
Gans MD, Gavrilova T
Paediatr Respir Rev 2020 Nov;36:118-127. Epub 2019 Oct 9 doi: 10.1016/j.prrv.2019.08.002. PMID: 31678040
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957

Therapy

Acute Invasive Pulmonary Aspergillosis: Clinical Presentation and Treatment.
Heylen J, Vanbiervliet Y, Maertens J, Rijnders B, Wauters J
Semin Respir Crit Care Med 2024 Feb;45(1):69-87. Epub 2024 Jan 11 doi: 10.1055/s-0043-1777769. PMID: 38211628
Aspergillosis: Epidemiology, Diagnosis, and Treatment.
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Invasive Pulmonary Aspergillosis.
Ledoux MP, Guffroy B, Nivoix Y, Simand C, Herbrecht R
Semin Respir Crit Care Med 2020 Feb;41(1):80-98. Epub 2020 Jan 30 doi: 10.1055/s-0039-3401990. PMID: 32000286
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial.
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM
Lancet Haematol 2017 Dec;4(12):e573-e583. Epub 2017 Nov 15 doi: 10.1016/S2352-3026(17)30211-9. PMID: 29153975

Prognosis

Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study.
Bartoletti M, Pascale R, Cricca M, Rinaldi M, Maccaro A, Bussini L, Fornaro G, Tonetti T, Pizzilli G, Francalanci E, Giuntoli L, Rubin A, Moroni A, Ambretti S, Trapani F, Vatamanu O, Ranieri VM, Castelli A, Baiocchi M, Lewis R, Giannella M, Viale P; PREDICO Study Group
Clin Infect Dis 2021 Dec 6;73(11):e3606-e3614. doi: 10.1093/cid/ciaa1065. PMID: 32719848Free PMC Article
Invasive Aspergillosis in solid-organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.
Husain S, Camargo JF
Clin Transplant 2019 Sep;33(9):e13544. Epub 2019 Apr 23 doi: 10.1111/ctr.13544. PMID: 30900296
Biomarkers of fungal lung infection.
Paiva JA, Pereira JM
Curr Opin Infect Dis 2019 Apr;32(2):136-142. doi: 10.1097/QCO.0000000000000523. PMID: 30640821
The spectrum of pulmonary aspergillosis.
Kanj A, Abdallah N, Soubani AO
Respir Med 2018 Aug;141:121-131. Epub 2018 Jul 3 doi: 10.1016/j.rmed.2018.06.029. PMID: 30053957
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Clinical prediction guides

Pathogenesis of Respiratory Viral and Fungal Coinfections.
Salazar F, Bignell E, Brown GD, Cook PC, Warris A
Clin Microbiol Rev 2022 Jan 19;35(1):e0009421. Epub 2021 Nov 17 doi: 10.1128/CMR.00094-21. PMID: 34788127Free PMC Article
Aspergillosis: Epidemiology, Diagnosis, and Treatment.
Cadena J, Thompson GR 3rd, Patterson TF
Infect Dis Clin North Am 2021 Jun;35(2):415-434. doi: 10.1016/j.idc.2021.03.008. PMID: 34016284
Epidemiology of Invasive Pulmonary Aspergillosis Among Intubated Patients With COVID-19: A Prospective Study.
Bartoletti M, Pascale R, Cricca M, Rinaldi M, Maccaro A, Bussini L, Fornaro G, Tonetti T, Pizzilli G, Francalanci E, Giuntoli L, Rubin A, Moroni A, Ambretti S, Trapani F, Vatamanu O, Ranieri VM, Castelli A, Baiocchi M, Lewis R, Giannella M, Viale P; PREDICO Study Group
Clin Infect Dis 2021 Dec 6;73(11):e3606-e3614. doi: 10.1093/cid/ciaa1065. PMID: 32719848Free PMC Article
The clinical spectrum of pulmonary aspergillosis.
Kosmidis C, Denning DW
Thorax 2015 Mar;70(3):270-7. Epub 2014 Oct 29 doi: 10.1136/thoraxjnl-2014-206291. PMID: 25354514
Pulmonary aspergillosis: a clinical review.
Kousha M, Tadi R, Soubani AO
Eur Respir Rev 2011 Sep 1;20(121):156-74. doi: 10.1183/09059180.00001011. PMID: 21881144Free PMC Article

Recent systematic reviews

Safety and usefulness of nebulized liposomal amphotericin B: Systematic scoping review.
Hagiya H, Nishimura Y, Otsuka F
Pulm Pharmacol Ther 2023 Oct;82:102233. Epub 2023 Jul 4 doi: 10.1016/j.pupt.2023.102233. PMID: 37414132
Management of pulmonary aspergillosis in children: a systematic review.
Terlizzi V, Motisi MA, Pellegrino R, Galli L, Taccetti G, Chiappini E
Ital J Pediatr 2023 Mar 28;49(1):39. doi: 10.1186/s13052-023-01440-9. PMID: 36978151Free PMC Article
Invasive fungal infections in acute and chronic liver impairment: A systematic review.
Lahmer T, Peçanha-Pietrobom PM, Schmid RM, Colombo AL
Mycoses 2022 Feb;65(2):140-151. Epub 2021 Dec 8 doi: 10.1111/myc.13403. PMID: 34837414
Intensive care medicine research agenda on invasive fungal infection in critically ill patients.
Bassetti M, Garnacho-Montero J, Calandra T, Kullberg B, Dimopoulos G, Azoulay E, Chakrabarti A, Kett D, Leon C, Ostrosky-Zeichner L, Sanguinetti M, Timsit JF, Richardson MD, Shorr A, Cornely OA
Intensive Care Med 2017 Sep;43(9):1225-1238. Epub 2017 Mar 2 doi: 10.1007/s00134-017-4731-2. PMID: 28255613
Systematic review of immunotherapy for chronic rhinosinusitis.
DeYoung K, Wentzel JL, Schlosser RJ, Nguyen SA, Soler ZM
Am J Rhinol Allergy 2014 Mar-Apr;28(2):145-50. doi: 10.2500/ajra.2014.28.4019. PMID: 24717953

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