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Brachial plexus neuritis

MedGen UID:
113170
•Concept ID:
C0221759
•
Disease or Syndrome
Synonyms: Brachial Neuritides; Brachial Neuritis; Brachial Plexus Neuritides; Brachial Plexus Neuritis; Girdle Neuropathies, Shoulder; Girdle Neuropathy, Shoulder; Neuritides, Brachial; Neuritides, Brachial Plexus; Neuritis, Brachial; Neuritis, Brachial Plexus; Neuropathies, Shoulder Girdle; Neuropathies, Shoulder-Girdle; Neuropathy, Shoulder Girdle; Neuropathy, Shoulder-Girdle; Parsonage Aldren Turner Syndrome; Parsonage Turner Syndrome; Parsonage-Aldren-Turner Syndrome; Parsonage-Turner Syndrome; Shoulder Girdle Neuropathies; Shoulder Girdle Neuropathy; Shoulder-Girdle Neuropathies; Shoulder-Girdle Neuropathy; Syndrome, Parsonage-Aldren-Turner; Syndrome, Parsonage-Turner
SNOMED CT: Brachial neuritis (72893007); Parsonage-Turner syndrome (26609002); Parsonage-Aldren-Turner syndrome (26609002); Shoulder girdle syndrome (26609002)
 
Monarch Initiative: MONDO:0006682

Definition

An inflammatory process affecting the brachial plexus. It results in severe pain in the upper extremity and shoulder, upper arm weakness and loss of sensation in the upper arm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrachial plexus neuritis
Follow this link to review classifications for Brachial plexus neuritis in Orphanet.

Professional guidelines

PubMed

ACR Appropriateness Criteria® Plexopathy: 2021 Update.
Expert Panel on Neurological and Musculoskeletal Imaging, Boulter DJ, Job J, Shah LM, Wessell DE, Lenchik L, Parsons MS, Agarwal V, Appel M, Burns J, Hutchins TA, Kendi AT, Khan MA, Liebeskind DS, Moritani T, Ortiz AO, Shah VN, Singh S, Than KD, Timpone VM, Beaman FD, Corey AS
J Am Coll Radiol 2021 Nov;18(11S):S423-S441. doi: 10.1016/j.jacr.2021.08.014. PMID: 34794598
ACR Appropriateness Criteria(®) Plexopathy.
Expert Panel on Neurologic Imaging:, Bykowski J, Aulino JM, Berger KL, Cassidy RC, Choudhri AF, Kendi AT, Kirsch CFE, Luttrull MD, Sharma A, Shetty VS, Than K, Winfree CJ, Cornelius RS
J Am Coll Radiol 2017 May;14(5S):S225-S233. doi: 10.1016/j.jacr.2017.02.002. PMID: 28473078
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis).
van Alfen N, van Engelen BG, Hughes RA
Cochrane Database Syst Rev 2009 Jul 8;2009(3):CD006976. doi: 10.1002/14651858.CD006976.pub2. PMID: 19588414Free PMC Article

Recent clinical studies

Etiology

Neuralgic Amyotrophy.
Holle JF, Limmroth V, Windisch W, Zimmerman M
Dtsch Arztebl Int 2024 Jul 26;121(15):483-489. doi: 10.3238/arztebl.m2024.0077. PMID: 38835178Free PMC Article
A standardized ultrasound approach in neuralgic amyotrophy.
Cignetti NE, Cox RS, Baute V, McGhee MB, van Alfen N, Strakowski JA, Boon AJ, Norbury JW, Cartwright MS
Muscle Nerve 2023 Jan;67(1):3-11. Epub 2022 Aug 30 doi: 10.1002/mus.27705. PMID: 36040106Free PMC Article
Challenging pain syndromes: Parsonage-Turner syndrome.
Smith CC, Bevelaqua AC
Phys Med Rehabil Clin N Am 2014 May;25(2):265-77. Epub 2014 Mar 18 doi: 10.1016/j.pmr.2014.01.001. PMID: 24787332
Idiopathic brachial neuritis.
Sumner AJ
Neurosurgery 2009 Oct;65(4 Suppl):A150-2. doi: 10.1227/01.NEU.0000345355.59438.D1. PMID: 19927060
Hereditary neuralgic amyotrophy.
Meuleman J, Timmerman V, Van Broeckhoven C, De Jonghe P
Neurogenetics 2001 Jul;3(3):115-8. doi: 10.1007/s100480100109. PMID: 11523561

Diagnosis

Parsonage-Turner Syndrome and Hereditary Brachial Plexus Neuropathy.
Meiling JB, Boon AJ, Niu Z, Howe BM, Hoskote SS, Spinner RJ, Klein CJ
Mayo Clin Proc 2024 Jan;99(1):124-140. doi: 10.1016/j.mayocp.2023.06.011. PMID: 38176820
A standardized ultrasound approach in neuralgic amyotrophy.
Cignetti NE, Cox RS, Baute V, McGhee MB, van Alfen N, Strakowski JA, Boon AJ, Norbury JW, Cartwright MS
Muscle Nerve 2023 Jan;67(1):3-11. Epub 2022 Aug 30 doi: 10.1002/mus.27705. PMID: 36040106Free PMC Article
Neuralgic amyotrophy.
IJspeert J, Janssen RMJ, van Alfen N
Curr Opin Neurol 2021 Oct 1;34(5):605-612. doi: 10.1097/WCO.0000000000000968. PMID: 34054111
Neuralgic amyotrophy: a paradigm shift in diagnosis and treatment.
Gstoettner C, Mayer JA, Rassam S, Hruby LA, Salminger S, Sturma A, Aman M, Harhaus L, Platzgummer H, Aszmann OC
J Neurol Neurosurg Psychiatry 2020 Aug;91(8):879-888. Epub 2020 Jun 2 doi: 10.1136/jnnp-2020-323164. PMID: 32487526
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment.
Van Eijk JJ, Groothuis JT, Van Alfen N
Muscle Nerve 2016 Mar;53(3):337-50. Epub 2016 Jan 20 doi: 10.1002/mus.25008. PMID: 26662794

Therapy

Neuralgic Amyotrophy.
Holle JF, Limmroth V, Windisch W, Zimmerman M
Dtsch Arztebl Int 2024 Jul 26;121(15):483-489. doi: 10.3238/arztebl.m2024.0077. PMID: 38835178Free PMC Article
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment.
Van Eijk JJ, Groothuis JT, Van Alfen N
Muscle Nerve 2016 Mar;53(3):337-50. Epub 2016 Jan 20 doi: 10.1002/mus.25008. PMID: 26662794
Challenging pain syndromes: Parsonage-Turner syndrome.
Smith CC, Bevelaqua AC
Phys Med Rehabil Clin N Am 2014 May;25(2):265-77. Epub 2014 Mar 18 doi: 10.1016/j.pmr.2014.01.001. PMID: 24787332
Neuralgic amyotrophy.
Sathasivam S, Lecky B, Manohar R, Selvan A
J Bone Joint Surg Br 2008 May;90(5):550-3. doi: 10.1302/0301-620X.90B5.20411. PMID: 18450616
Neuralgic amyotrophy.
Aymond JK, Goldner JL, Hardaker WT Jr
Orthop Rev 1989 Dec;18(12):1275-9. PMID: 2687774

Prognosis

Neuralgic Amyotrophy.
Holle JF, Limmroth V, Windisch W, Zimmerman M
Dtsch Arztebl Int 2024 Jul 26;121(15):483-489. doi: 10.3238/arztebl.m2024.0077. PMID: 38835178Free PMC Article
A standardized ultrasound approach in neuralgic amyotrophy.
Cignetti NE, Cox RS, Baute V, McGhee MB, van Alfen N, Strakowski JA, Boon AJ, Norbury JW, Cartwright MS
Muscle Nerve 2023 Jan;67(1):3-11. Epub 2022 Aug 30 doi: 10.1002/mus.27705. PMID: 36040106Free PMC Article
Benign focal amyotrophy.
Cintas P
Rev Neurol (Paris) 2017 May;173(5):338-344. Epub 2017 Apr 24 doi: 10.1016/j.neurol.2017.03.016. PMID: 28449880
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment.
Van Eijk JJ, Groothuis JT, Van Alfen N
Muscle Nerve 2016 Mar;53(3):337-50. Epub 2016 Jan 20 doi: 10.1002/mus.25008. PMID: 26662794
Neuralgic amyotrophy.
Sathasivam S, Lecky B, Manohar R, Selvan A
J Bone Joint Surg Br 2008 May;90(5):550-3. doi: 10.1302/0301-620X.90B5.20411. PMID: 18450616

Clinical prediction guides

A standardized ultrasound approach in neuralgic amyotrophy.
Cignetti NE, Cox RS, Baute V, McGhee MB, van Alfen N, Strakowski JA, Boon AJ, Norbury JW, Cartwright MS
Muscle Nerve 2023 Jan;67(1):3-11. Epub 2022 Aug 30 doi: 10.1002/mus.27705. PMID: 36040106Free PMC Article
Parsonage-Turner syndrome and cytomegalovirus disease.
Mastroianni A, Mauro MV
Clin Neuropathol 2022 May-Jun;41(3):135-144. doi: 10.5414/NP301409. PMID: 35142284
Neuralgic amyotrophy: a paradigm shift in diagnosis and treatment.
Gstoettner C, Mayer JA, Rassam S, Hruby LA, Salminger S, Sturma A, Aman M, Harhaus L, Platzgummer H, Aszmann OC
J Neurol Neurosurg Psychiatry 2020 Aug;91(8):879-888. Epub 2020 Jun 2 doi: 10.1136/jnnp-2020-323164. PMID: 32487526
Hepatitis E virus: Infection beyond the liver?
Pischke S, Hartl J, Pas SD, Lohse AW, Jacobs BC, Van der Eijk AA
J Hepatol 2017 May;66(5):1082-1095. Epub 2016 Nov 29 doi: 10.1016/j.jhep.2016.11.016. PMID: 27913223
Neuralgic amyotrophy: An update on diagnosis, pathophysiology, and treatment.
Van Eijk JJ, Groothuis JT, Van Alfen N
Muscle Nerve 2016 Mar;53(3):337-50. Epub 2016 Jan 20 doi: 10.1002/mus.25008. PMID: 26662794

Recent systematic reviews

Association of Parsonage-Turner syndrome with COVID-19 infection and vaccination: a systematic review.
Ameer MZ, Haiy AU, Bajwa MH, Abeer H, Mustafa B, Ameer F, Amjad Z, Rehman AU
J Int Med Res 2023 Jul;51(7):3000605231187939. doi: 10.1177/03000605231187939. PMID: 37523491Free PMC Article
Shoulder Pain and Dysfunction After Vaccination: A Systematic Review.
Wright JO, Wiggins W, Smith MS, King JJ, Wright TW
JBJS Rev 2023 Jan 1;11(1) Epub 2023 Jan 12 doi: 10.2106/JBJS.RVW.22.00134. PMID: 36722836
A systematic literature review on the effectiveness of non-invasive therapy for cervicobrachial pain.
Salt E, Wright C, Kelly S, Dean A
Man Ther 2011 Feb;16(1):53-65. Epub 2010 Nov 12 doi: 10.1016/j.math.2010.09.005. PMID: 21075037
Treatment for idiopathic and hereditary neuralgic amyotrophy (brachial neuritis).
van Alfen N, van Engelen BG, Hughes RA
Cochrane Database Syst Rev 2009 Jul 8;2009(3):CD006976. doi: 10.1002/14651858.CD006976.pub2. PMID: 19588414Free PMC Article

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