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Neurogenic shock

MedGen UID:
107781
•Concept ID:
C0544617
•
Pathologic Function
Synonyms: Neurogenic Shock; Vasogenic Shock
SNOMED CT: Neurogenic shock (129577007)

Definition

Shock resulting from neurogenic vasodilation, which can be produced by cerebral trauma or hemorrhage, spinal cord injury, deep general or spinal anesthesia, or toxic central nervous system depression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurogenic shock

Professional guidelines

PubMed

Acute Management of Cervical Spinal Cord Injuries.
Hunt A, McQuillan KA
Crit Care Nurs Clin North Am 2023 Jun;35(2):119-128. Epub 2023 Mar 27 doi: 10.1016/j.cnc.2023.02.004. PMID: 37127369
Spinal shock. Assessment & treatment of spinal cord injuries & neurogenic shock.
Fox AD
JEMS 2014 Nov;39(11):64-7. PMID: 25630163
Critical care and perioperative management in traumatic spinal cord injury.
Stevens RD, Bhardwaj A, Kirsch JR, Mirski MA
J Neurosurg Anesthesiol 2003 Jul;15(3):215-29. doi: 10.1097/00008506-200307000-00009. PMID: 12826969

Recent clinical studies

Etiology

Neurogenic Shock: A Case Report.
North N, Adams A
J Emerg Nurs 2023 Jul;49(4):495-498. doi: 10.1016/j.jen.2023.04.003. PMID: 37393074
Alterations in cardiac autonomic control in spinal cord injury.
Biering-Sørensen F, Biering-Sørensen T, Liu N, Malmqvist L, Wecht JM, Krassioukov A
Auton Neurosci 2018 Jan;209:4-18. Epub 2017 Feb 15 doi: 10.1016/j.autneu.2017.02.004. PMID: 28228335
Bradycardia in neurosurgery.
Agrawal A, Timothy J, Cincu R, Agarwal T, Waghmare LB
Clin Neurol Neurosurg 2008 Apr;110(4):321-7. Epub 2008 Mar 7 doi: 10.1016/j.clineuro.2008.01.013. PMID: 18329164
Spinal injuries.
Mackenzie R
J R Army Med Corps 2002 Jun;148(2):163-71. doi: 10.1136/jramc-148-02-11. PMID: 12174560
The pathophysiology of shock.
Skowronski GA
Med J Aust 1988 Jun 6;148(11):576-9, 582-3. PMID: 3287110

Diagnosis

Neurogenic Shock: A Case Report.
North N, Adams A
J Emerg Nurs 2023 Jul;49(4):495-498. doi: 10.1016/j.jen.2023.04.003. PMID: 37393074
Alterations in cardiac autonomic control in spinal cord injury.
Biering-Sørensen F, Biering-Sørensen T, Liu N, Malmqvist L, Wecht JM, Krassioukov A
Auton Neurosci 2018 Jan;209:4-18. Epub 2017 Feb 15 doi: 10.1016/j.autneu.2017.02.004. PMID: 28228335
Update on traumatic acute spinal cord injury. Part 1.
Galeiras Vázquez R, Ferreiro Velasco ME, Mourelo Fariña M, Montoto Marqués A, Salvador de la Barrera S
Med Intensiva 2017 May;41(4):237-247. Epub 2017 Feb 1 doi: 10.1016/j.medin.2016.11.002. PMID: 28161028
Spinal injuries.
Mackenzie R
J R Army Med Corps 2002 Jun;148(2):163-71. doi: 10.1136/jramc-148-02-11. PMID: 12174560
The pathophysiology of shock.
Skowronski GA
Med J Aust 1988 Jun 6;148(11):576-9, 582-3. PMID: 3287110

Therapy

Emergency Neuropharmacology.
DeWitt KM, Porter BA
Emerg Med Clin North Am 2021 Feb;39(1):133-154. Epub 2020 Nov 5 doi: 10.1016/j.emc.2020.09.008. PMID: 33218654
Vasopressor support in managing acute spinal cord injury: current knowledge.
Yue JK, Tsolinas RE, Burke JF, Deng H, Upadhyayula PS, Robinson CK, Lee YM, Chan AK, Winkler EA, Dhall SS
J Neurosurg Sci 2019 Jun;63(3):308-317. Epub 2017 Mar 1 doi: 10.23736/S0390-5616.17.04003-6. PMID: 28252264
Early neurological care of patients with spinal cord injury.
Kessler TM, Traini LR, Welk B, Schneider MP, Thavaseelan J, Curt A
World J Urol 2018 Oct;36(10):1529-1536. Epub 2018 May 28 doi: 10.1007/s00345-018-2343-2. PMID: 29808302
Update on traumatic acute spinal cord injury. Part 1.
Galeiras Vázquez R, Ferreiro Velasco ME, Mourelo Fariña M, Montoto Marqués A, Salvador de la Barrera S
Med Intensiva 2017 May;41(4):237-247. Epub 2017 Feb 1 doi: 10.1016/j.medin.2016.11.002. PMID: 28161028
Terlipressin in brain-death donors.
Piazza O, Scarpati G, Rispoli F, Iannuzzi M, Tufano R, De Robertis E
Clin Transplant 2012 Nov-Dec;26(6):E571-5. Epub 2012 Nov 2 doi: 10.1111/ctr.12038. PMID: 23121213

Prognosis

Incidence and Natural Progression of Neurogenic Shock after Traumatic Spinal Cord Injury.
Ruiz IA, Squair JW, Phillips AA, Lukac CD, Huang D, Oxciano P, Yan D, Krassioukov AV
J Neurotrauma 2018 Feb 1;35(3):461-466. Epub 2017 Dec 18 doi: 10.1089/neu.2016.4947. PMID: 29141498
Update on traumatic acute spinal cord injury. Part 1.
Galeiras Vázquez R, Ferreiro Velasco ME, Mourelo Fariña M, Montoto Marqués A, Salvador de la Barrera S
Med Intensiva 2017 May;41(4):237-247. Epub 2017 Feb 1 doi: 10.1016/j.medin.2016.11.002. PMID: 28161028
Spinal shock. Assessment & treatment of spinal cord injuries & neurogenic shock.
Fox AD
JEMS 2014 Nov;39(11):64-7. PMID: 25630163
Cardiac dysfunctions following spinal cord injury.
Grigorean VT, Sandu AM, Popescu M, Iacobini MA, Stoian R, Neascu C, Strambu V, Popa F
J Med Life 2009 Apr-Jun;2(2):133-45. PMID: 20108532Free PMC Article
Acute spinal cord injury, part I: pathophysiologic mechanisms.
Dumont RJ, Okonkwo DO, Verma S, Hurlbert RJ, Boulos PT, Ellegala DB, Dumont AS
Clin Neuropharmacol 2001 Sep-Oct;24(5):254-64. doi: 10.1097/00002826-200109000-00002. PMID: 11586110

Clinical prediction guides

Use of the ice water test as an early predictor of recovery of erectile function in patients with spinal cord injury.
Hadiji N, Prévinaire JG, Soler JM
Spinal Cord Ser Cases 2020 Jun 29;6(1):51. doi: 10.1038/s41394-020-0300-y. PMID: 32601269Free PMC Article
Vasopressor support in managing acute spinal cord injury: current knowledge.
Yue JK, Tsolinas RE, Burke JF, Deng H, Upadhyayula PS, Robinson CK, Lee YM, Chan AK, Winkler EA, Dhall SS
J Neurosurg Sci 2019 Jun;63(3):308-317. Epub 2017 Mar 1 doi: 10.23736/S0390-5616.17.04003-6. PMID: 28252264
Bradycardia in neurosurgery.
Agrawal A, Timothy J, Cincu R, Agarwal T, Waghmare LB
Clin Neurol Neurosurg 2008 Apr;110(4):321-7. Epub 2008 Mar 7 doi: 10.1016/j.clineuro.2008.01.013. PMID: 18329164
Cervical spinal cord injury and the need for cardiovascular intervention.
Bilello JF, Davis JW, Cunningham MA, Groom TF, Lemaster D, Sue LP
Arch Surg 2003 Oct;138(10):1127-9. doi: 10.1001/archsurg.138.10.1127. PMID: 14557131
Critical care and perioperative management in traumatic spinal cord injury.
Stevens RD, Bhardwaj A, Kirsch JR, Mirski MA
J Neurosurg Anesthesiol 2003 Jul;15(3):215-29. doi: 10.1097/00008506-200307000-00009. PMID: 12826969

Recent systematic reviews

A systematic review of intensive cardiopulmonary management after spinal cord injury.
Casha S, Christie S
J Neurotrauma 2011 Aug;28(8):1479-95. Epub 2010 Apr 8 doi: 10.1089/neu.2009.1156. PMID: 20030558Free PMC Article

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