U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Terminal insomnia

MedGen UID:
107755
•Concept ID:
C0541798
•
Mental or Behavioral Dysfunction
Synonyms: Awakening, Early; Early Awakening
SNOMED CT: Terminal insomnia (67062000); Matutinal insomnia (67062000); Early morning waking (401236004); Early waking (67062000); Wakes and cannot sleep again (67062000); Wakes early (67062000)
 
HPO: HP:0031356

Definition

A type of insomnia characterized by waking up too early in the morning is known as early morning awakening. The termination of sleep must occur at least 30 minutes before the desired time. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTerminal insomnia

Professional guidelines

PubMed

Insomnia as an expression of obstructive sleep apnea syndrome--the effect of treatment with nocturnal ventilatory support.
Mendes MS, dos Santos JM
Rev Port Pneumol (2006) 2015 Jul-Aug;21(4):203-8. Epub 2015 Feb 11 doi: 10.1016/j.rppnen.2014.11.002. PMID: 25926264
Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate.
Murali H, Kotagal S
Sleep 2006 Aug;29(8):1025-9. doi: 10.1093/sleep/29.8.1025. PMID: 16944670

Recent clinical studies

Etiology

Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis.
Cohen S, Goldsmith DR, Ning CS, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Keshavan M, Mathalon DH, Perkins DO, Seidman LJ, Stone WS, Tsuang MT, Woods SW, Walker EF, Miller BJ
Psychiatry Res 2024 Nov;341:116147. Epub 2024 Aug 20 doi: 10.1016/j.psychres.2024.116147. PMID: 39197223
Exploring adverse events of Vilazodone: evidence from the FAERS database.
Jiang Y, Qu Y, Du Z, Ou M, Shen Y, Zhou Q, Tian L, Zhu H
BMC Psychiatry 2024 May 16;24(1):371. doi: 10.1186/s12888-024-05813-0. PMID: 38755677Free PMC Article
Sleep disturbances and dementia risk: A multicenter study.
Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M
Alzheimers Dement 2018 Oct;14(10):1235-1242. Epub 2018 Jul 17 doi: 10.1016/j.jalz.2018.05.012. PMID: 30030112
Sleep and fatigue in multiple sclerosis.
Stanton BR, Barnes F, Silber E
Mult Scler 2006 Aug;12(4):481-6. doi: 10.1191/135248506ms1320oa. PMID: 16900762
Modelling late-life depression.
Parker G, Snowdon J, Parker K
Int J Geriatr Psychiatry 2003 Dec;18(12):1102-9. doi: 10.1002/gps.1020. PMID: 14677142

Diagnosis

Differences in anxiety levels among symptoms of insomnia. The HUNT study.
Bragantini D, Sivertsen B, Gehrman P, Lydersen S, Güzey IC
Sleep Health 2019 Aug;5(4):370-375. Epub 2019 Feb 8 doi: 10.1016/j.sleh.2019.01.002. PMID: 31400882
Distress Related to Individual Depressive Symptoms: A Cross-sectional Study in Thai Patients with Major Depression.
Rungpetchwong T, Likhitsathian S, Jaranai S, Srisurapanont M
East Asian Arch Psychiatry 2017 Sep;27(3):115-20. PMID: 28993544
The Role of Sleep Disturbance in Suicidal and Nonsuicidal Self-Injurious Behavior among Adolescents.
McGlinchey EL, Courtney-Seidler EA, German M, Miller AL
Suicide Life Threat Behav 2017 Feb;47(1):103-111. Epub 2016 Jun 7 doi: 10.1111/sltb.12268. PMID: 27273654
Age-related characteristics of depression: a preliminary STAR*D report.
Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R
Am J Geriatr Psychiatry 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852. PMID: 16223963
Nightmares and terminal insomnia in depressed patients with and without melancholic features.
Besiroglu L, Agargun MY, Inci R
Psychiatry Res 2005 Feb 28;133(2-3):285-7. doi: 10.1016/j.psychres.2004.12.001. PMID: 15741005

Therapy

Exploring adverse events of Vilazodone: evidence from the FAERS database.
Jiang Y, Qu Y, Du Z, Ou M, Shen Y, Zhou Q, Tian L, Zhu H
BMC Psychiatry 2024 May 16;24(1):371. doi: 10.1186/s12888-024-05813-0. PMID: 38755677Free PMC Article
Insomnia and inflammation in phase 1 of the clinical antipsychotic trials of intervention effectiveness study.
Miller BJ, McCall WV, McEvoy JP, Lu XY
Psychiatry Res 2021 Nov;305:114195. Epub 2021 Aug 29 doi: 10.1016/j.psychres.2021.114195. PMID: 34481199
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Insomnia as a predictor for symptom worsening following antipsychotic withdrawal in schizophrenia.
Chemerinski E, Ho BC, Flaum M, Arndt S, Fleming F, Andreasen NC
Compr Psychiatry 2002 Sep-Oct;43(5):393-6. doi: 10.1053/comp.2002.34627. PMID: 12216015
Cyclic AMP second-messenger signal amplification in depression.
Ebstein RP, Lerer B, Shapira B, Shemesh Z, Moscovich DG, Kindler S
Br J Psychiatry 1988 May;152:665-9. doi: 10.1192/bjp.152.5.665. PMID: 2844354

Prognosis

Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Sleep disturbances and dementia risk: A multicenter study.
Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M
Alzheimers Dement 2018 Oct;14(10):1235-1242. Epub 2018 Jul 17 doi: 10.1016/j.jalz.2018.05.012. PMID: 30030112
The Role of Sleep Disturbance in Suicidal and Nonsuicidal Self-Injurious Behavior among Adolescents.
McGlinchey EL, Courtney-Seidler EA, German M, Miller AL
Suicide Life Threat Behav 2017 Feb;47(1):103-111. Epub 2016 Jun 7 doi: 10.1111/sltb.12268. PMID: 27273654
Off-label treatment of severe childhood narcolepsy-cataplexy with sodium oxybate.
Murali H, Kotagal S
Sleep 2006 Aug;29(8):1025-9. doi: 10.1093/sleep/29.8.1025. PMID: 16944670
Age-related characteristics of depression: a preliminary STAR*D report.
Husain MM, Rush AJ, Sackeim HA, Wisniewski SR, McClintock SM, Craven N, Holiner J, Mitchell JR, Balasubramani GK, Hauger R
Am J Geriatr Psychiatry 2005 Oct;13(10):852-60. doi: 10.1176/appi.ajgp.13.10.852. PMID: 16223963

Clinical prediction guides

Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis.
Cohen S, Goldsmith DR, Ning CS, Addington J, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Keshavan M, Mathalon DH, Perkins DO, Seidman LJ, Stone WS, Tsuang MT, Woods SW, Walker EF, Miller BJ
Psychiatry Res 2024 Nov;341:116147. Epub 2024 Aug 20 doi: 10.1016/j.psychres.2024.116147. PMID: 39197223
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Differences in anxiety levels among symptoms of insomnia. The HUNT study.
Bragantini D, Sivertsen B, Gehrman P, Lydersen S, Güzey IC
Sleep Health 2019 Aug;5(4):370-375. Epub 2019 Feb 8 doi: 10.1016/j.sleh.2019.01.002. PMID: 31400882
Distress Related to Individual Depressive Symptoms: A Cross-sectional Study in Thai Patients with Major Depression.
Rungpetchwong T, Likhitsathian S, Jaranai S, Srisurapanont M
East Asian Arch Psychiatry 2017 Sep;27(3):115-20. PMID: 28993544
Modelling late-life depression.
Parker G, Snowdon J, Parker K
Int J Geriatr Psychiatry 2003 Dec;18(12):1102-9. doi: 10.1002/gps.1020. PMID: 14677142

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...