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Diminished prolactin response to thyrotrophin-releasing hormone stimulation

MedGen UID:
1054838
•Concept ID:
CN376754
•
Finding
HPO: HP:6000241

Definition

The increase in prolactin concentration (PRL) following stimulation with thyrotropin (thyrdoid releasing hormone) as compared to baseline PRL concentration is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiminished prolactin response to thyrotrophin-releasing hormone stimulation

Recent clinical studies

Therapy

Ovulation induction with pulsatile gonadotropin-releasing hormone (GnRH) or gonadotropins in a case of hypothalamic amenorrhea and diabetes insipidus.
Georgopoulos NA, Markou KB, Pappas AP, Protonatariou A, Vagenakis GA, Sykiotis GP, Dimopoulos PA, Tzingounis VA
Gynecol Endocrinol 2001 Dec;15(6):421-5. PMID: 11826765
Effects of atrial natriuretic factor on anterior pituitary hormone secretion in normal man.
Kentsch M, Lawrenz R, Ball P, Gerzer R, Müller-Esch G
Clin Investig 1992 Jul;70(7):549-55. doi: 10.1007/BF00184789. PMID: 1392423
Behavioral and endocrine responses of schizophrenic patients to TRH (protirelin).
Prange AJ Jr, Loosen PT, Wilson IC, Meltzer HY, Fang VS
Arch Gen Psychiatry 1979 Sep;36(10):1086-93. doi: 10.1001/archpsyc.1979.01780100056005. PMID: 112944
Effect of sulpiride on serum growth hormone and prolactin concentrations following L-DOPA administration in man.
Mori M, Kobayashi I, Shimoyama S, Uehara T, Nemoto T
Endocrinol Jpn 1977 Apr;24(2):149-53. doi: 10.1507/endocrj1954.24.149. PMID: 406134
Thyrotropin-releasing hormone: differential antidepressant and endocrinological effects.
Furlong FW, Brown GM, Beeching MF
Am J Psychiatry 1976 Oct;133(10):1187-90. doi: 10.1176/ajp.133.10.1187. PMID: 823828

Prognosis

Impaired secretion of TSH in critically ill patients with 'low T4-syndrome'.
Vierhapper H, Laggner A, Waldhäusl W, Grubeck-Loebenstein B, Kleinberger G
Acta Endocrinol (Copenh) 1982 Dec;101(4):542-9. doi: 10.1530/acta.0.1010542. PMID: 6818804
Biological markers of melancholia and reclassification of depressive disorders.
Greden JF
Encephale 1982;8(2):193-202. PMID: 6809444

Clinical prediction guides

Dose-response studies with thyrotropin-releasing hormone (TRH) in abstinent male alcoholics: evidence for selective thyrotroph dysfunction?
Garbutt JC, Mayo JP Jr, Gillette GM, Little KY, Hicks RE, Mason GA, Prange AJ Jr
J Stud Alcohol 1991 May;52(3):275-80. doi: 10.15288/jsa.1991.52.275. PMID: 1646352
Effect of sulpiride on serum growth hormone and prolactin concentrations following L-DOPA administration in man.
Mori M, Kobayashi I, Shimoyama S, Uehara T, Nemoto T
Endocrinol Jpn 1977 Apr;24(2):149-53. doi: 10.1507/endocrj1954.24.149. PMID: 406134
Stimulation of growth hormone release by luteinizing hormone-releasing hormone in two males with isolated gonadotropin deficiency.
Kasagi K, Oishi M, Nishikawa M, Kurata S, Inada M, Kato Y, Imura H
Endocrinol Jpn 1976 Oct;23(5):383-90. doi: 10.1507/endocrj1954.23.383. PMID: 827432
Pituitary hormone responses to hypothalamic releasing hormones in acromegaly.
Cantalamessa L, Reschini E, Catania A, Giustina G
Acta Endocrinol (Copenh) 1976 Dec;83(4):673-83. doi: 10.1530/acta.0.0830673. PMID: 826061
Hypothalamic-pituitary functions in patients with idiopathic pituitary dwarfism.
Demura R, Jujo K, Takano K, Odagiri E, Maeda T, Suda T, Demura H, Shizume K
Endocrinol Jpn 1975 Apr;22(2):97-103. doi: 10.1507/endocrj1954.22.97. PMID: 807471

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