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Tympanic membrane bulla

MedGen UID:
1054744
•Concept ID:
CN377018
•
Finding
Synonyms: Bullous myringitis; Tympanic membrane blister
 
HPO: HP:6000422

Definition

Presence of blisters (bullae) on the tympanic membrane, often accompanied by fever, thickening, and erythematous appearance of the tympanic membrane, decreased or absent light reflex, and decreased mobility. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTympanic membrane bulla

Professional guidelines

PubMed

Diagnosis and treatment of the child with a draining ear.
Ramsey AM
J Pediatr Health Care 2002 Jul-Aug;16(4):161-9. PMID: 12122378
Management of acute ear infections.
Walike JW
Otolaryngol Clin North Am 1979 May;12(2):439-45. PMID: 460883

Recent clinical studies

Etiology

Chronic tympanic membrane perforation repair with a collagen-based scaffold: An in vivo model.
Harvey EA, Hong W, Sheehy EJ, do Amaral RJ, Khampang P, Runge CL, O'Leary C, O'Brien FJ, Kerschner JE
Int J Pediatr Otorhinolaryngol 2024 Jan;176:111807. Epub 2023 Dec 1 doi: 10.1016/j.ijporl.2023.111807. PMID: 38134588
Symptoms and otoscopic signs in bilateral and unilateral acute otitis media.
Uitti JM, Laine MK, Tähtinen PA, Ruuskanen O, Ruohola A
Pediatrics 2013 Feb;131(2):e398-405. Epub 2013 Jan 28 doi: 10.1542/peds.2012-1188. PMID: 23359578
Postoperative granuloma after stapedectomy: is it destiny or avoidable?
Batman C, Öztürk Ö, Ramadan SS
Adv Otorhinolaryngol 2007;65:285-295. doi: 10.1159/000098844. PMID: 17245060
Autoimmunity in the etiology of otitis media with effusion.
Kirglu M, Yildirim I, Aydogan B, Okur E, Tuncer U, Erken E
Am J Otolaryngol 2003 May-Jun;24(3):159-62. doi: 10.1016/s0196-0709(02)32425-6. PMID: 12761702
Diagnosis and treatment of the child with a draining ear.
Ramsey AM
J Pediatr Health Care 2002 Jul-Aug;16(4):161-9. PMID: 12122378

Diagnosis

Symptoms and otoscopic signs in bilateral and unilateral acute otitis media.
Uitti JM, Laine MK, Tähtinen PA, Ruuskanen O, Ruohola A
Pediatrics 2013 Feb;131(2):e398-405. Epub 2013 Jan 28 doi: 10.1542/peds.2012-1188. PMID: 23359578
Bullous hemorrhagic myringitis.
Elzir L, Saliba I
Otolaryngol Head Neck Surg 2013 Feb;148(2):347-8. Epub 2012 Dec 13 doi: 10.1177/0194599812471488. PMID: 23239808
Hearing loss in bullous myringitis.
Drendel M, Yakirevitch A, Kerimis P, Migirov L, Wolf M
Auris Nasus Larynx 2012 Feb;39(1):28-30. Epub 2011 May 23 doi: 10.1016/j.anl.2011.04.001. PMID: 21601393
Bullous myringitis: a case-control study.
McCormick DP, Saeed KA, Pittman C, Baldwin CD, Friedman N, Teichgraeber DC, Chonmaitree T
Pediatrics 2003 Oct;112(4):982-6. doi: 10.1542/peds.112.4.982. PMID: 14523199
Diagnosis and treatment of the child with a draining ear.
Ramsey AM
J Pediatr Health Care 2002 Jul-Aug;16(4):161-9. PMID: 12122378

Therapy

Bullous hemorrhagic myringitis.
Elzir L, Saliba I
Otolaryngol Head Neck Surg 2013 Feb;148(2):347-8. Epub 2012 Dec 13 doi: 10.1177/0194599812471488. PMID: 23239808
The epidemiology of acute bullous myringitis and its relationship to recurrent acute otitis media in children less than 2 years of age.
Kotikoski MJ, Palmu AA, Huhtala H, Savolainen H, Puhakka HJ
Int J Pediatr Otorhinolaryngol 2003 Nov;67(11):1207-12. doi: 10.1016/j.ijporl.2003.07.010. PMID: 14597372
Bullous myringitis: a case-control study.
McCormick DP, Saeed KA, Pittman C, Baldwin CD, Friedman N, Teichgraeber DC, Chonmaitree T
Pediatrics 2003 Oct;112(4):982-6. doi: 10.1542/peds.112.4.982. PMID: 14523199
Immune-mediated otitis media with effusion.
Suzuki M, Kawauchi H, Mogi G
Am J Otolaryngol 1988 Sep-Oct;9(5):199-209. doi: 10.1016/s0196-0709(88)80028-0. PMID: 3228178
Contraindications to the small hole stapedectomy.
Farrior B
Ann Otol Rhinol Laryngol 1981 Nov-Dec;90(6 Pt 1):636-9. doi: 10.1177/000348948109000627. PMID: 7316390

Prognosis

Temporal bone metastasis as a sign of relapsing chronic lymphocytic leukemia.
Aljafar HM, Alsuhibani SS, Alahmari MS, Alzahrani MA
Saudi Med J 2015 Oct;36(10):1233-5. doi: 10.15537/smj.2015.10.12259. PMID: 26446337Free PMC Article
Symptoms and otoscopic signs in bilateral and unilateral acute otitis media.
Uitti JM, Laine MK, Tähtinen PA, Ruuskanen O, Ruohola A
Pediatrics 2013 Feb;131(2):e398-405. Epub 2013 Jan 28 doi: 10.1542/peds.2012-1188. PMID: 23359578
The epidemiology of acute bullous myringitis and its relationship to recurrent acute otitis media in children less than 2 years of age.
Kotikoski MJ, Palmu AA, Huhtala H, Savolainen H, Puhakka HJ
Int J Pediatr Otorhinolaryngol 2003 Nov;67(11):1207-12. doi: 10.1016/j.ijporl.2003.07.010. PMID: 14597372
Myringitis bullosa haemorrhagica: clinical course influenced by tympanosclerosis.
Woo JK, van Hasselt CA, Gluckman PG
J Laryngol Otol 1992 Feb;106(2):162-3. doi: 10.1017/s0022215100118961. PMID: 1556493
The etiology and clinical course of bullous myringitis.
Merifield DO, Miller GS
Arch Otolaryngol 1966 Nov;84(5):487-9. doi: 10.1001/archotol.1966.00760030489004. PMID: 4289080

Clinical prediction guides

Tomodensitometric and histological age-related changes in the normal feline middle and inner ear.
Montel C, Arribarat G, Cartiaux B, Gaide N, Mogicato G
Anat Histol Embryol 2023 Sep;52(5):798-804. Epub 2023 Jun 19 doi: 10.1111/ahe.12939. PMID: 37334847
Symptoms and otoscopic signs in bilateral and unilateral acute otitis media.
Uitti JM, Laine MK, Tähtinen PA, Ruuskanen O, Ruohola A
Pediatrics 2013 Feb;131(2):e398-405. Epub 2013 Jan 28 doi: 10.1542/peds.2012-1188. PMID: 23359578
Hearing loss in bullous myringitis.
Drendel M, Yakirevitch A, Kerimis P, Migirov L, Wolf M
Auris Nasus Larynx 2012 Feb;39(1):28-30. Epub 2011 May 23 doi: 10.1016/j.anl.2011.04.001. PMID: 21601393
A histologic study on the temporal bone of guinea pigs.
Kayhan FT, Algün Z
Kulak Burun Bogaz Ihtis Derg 2003 Feb;10(2):51-7. PMID: 12717057
Tympanograms of otitis media with effusion: an experimental study.
Okitsu T, Kobayashi T, Endo S, Shibahara Y, Sakuma M, Takasaka T, Kawamoto K, Kaneko Y
Auris Nasus Larynx 1985;12 Suppl 1:S222-4. doi: 10.1016/s0385-8146(85)80156-5. PMID: 3835915

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