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Cerebrospinal fluid eosinophilia

MedGen UID:
1054537
•Concept ID:
CN377972
•
Finding
Synonym: Eosinophilia in the CSF
 
HPO: HP:6000824

Definition

Presence of at least 10% eosinophils in the total cerebrospinal fluid (CSF) leukocyte count. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebrospinal fluid eosinophilia

Professional guidelines

PubMed

Clinical Characteristics and Treatment Outcome of Eosinophilic Meningoencephalitis in South Indian Children: Experience From a Prospective Registry.
Vinayan KP, Dudipala SC, Roy AG, Anand V
Pediatr Neurol 2023 Oct;147:9-13. Epub 2023 Jul 4 doi: 10.1016/j.pediatrneurol.2023.06.023. PMID: 37516067
Differential diagnosis of CNS angiostrongyliasis: a short review.
Senthong V, Chindaprasirt J, Sawanyawisuth K
Hawaii J Med Public Health 2013 Jun;72(6 Suppl 2):52-4. PMID: 23901385Free PMC Article
Treatment of angiostrongyliasis.
Sawanyawisuth K, Sawanyawisuth K
Trans R Soc Trop Med Hyg 2008 Oct;102(10):990-6. Epub 2008 May 27 doi: 10.1016/j.trstmh.2008.04.021. PMID: 18501934

Recent clinical studies

Etiology

Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis.
Mansbridge CT, Norton NJ, Fox SM
Am J Trop Med Hyg 2020 Nov 23;104(2):731-733. doi: 10.4269/ajtmh.20-1018. PMID: 33236700Free PMC Article
Cerebrospinal fluid eosinophilia in children with ventricular shunts.
Fulkerson DH, Boaz JC
J Neurosurg Pediatr 2008 Apr;1(4):288-95. doi: 10.3171/PED/2008/1/4/288. PMID: 18377304
Raccoon roundworm encephalitis.
Murray WJ, Kazacos KR
Clin Infect Dis 2004 Nov 15;39(10):1484-92. Epub 2004 Oct 27 doi: 10.1086/425364. PMID: 15546085
Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases.
Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM
Am J Med 2001 Aug;111(2):109-14. doi: 10.1016/s0002-9343(01)00766-5. PMID: 11498063
Ventricular cerebrospinal fluid eosinophilia in children with ventriculoperitoneal shunts.
Tung H, Raffel C, McComb JG
J Neurosurg 1991 Oct;75(4):541-4. doi: 10.3171/jns.1991.75.4.0541. PMID: 1885971

Diagnosis

Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis.
Mansbridge CT, Norton NJ, Fox SM
Am J Trop Med Hyg 2020 Nov 23;104(2):731-733. doi: 10.4269/ajtmh.20-1018. PMID: 33236700Free PMC Article
Raccoon roundworm encephalitis.
Murray WJ, Kazacos KR
Clin Infect Dis 2004 Nov 15;39(10):1484-92. Epub 2004 Oct 27 doi: 10.1086/425364. PMID: 15546085
Angiostrongylus cantonensis infection mimicking a spinal cord tumor.
Petjom S, Chaiwun B, Settakorn J, Visrutaratna P, Rangdaeng S, Thorner PS
Ann Neurol 2002 Jul;52(1):99-101. doi: 10.1002/ana.10215. PMID: 12112054
Eosinophilic meningitis caused by Rocky Mountain spotted fever.
Crennan JM, Van Scoy RE
Am J Med 1986 Feb;80(2):288-9. doi: 10.1016/0002-9343(86)90023-9. PMID: 3946444
Cysticercosis update.
Grisolia JS
West J Med 1984 Jun;140(6):901-4. PMID: 6377706Free PMC Article

Therapy

Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis.
Mansbridge CT, Norton NJ, Fox SM
Am J Trop Med Hyg 2020 Nov 23;104(2):731-733. doi: 10.4269/ajtmh.20-1018. PMID: 33236700Free PMC Article
Ventriculoperitoneal shunt malfunction from cerebrospinal fluid eosinophilia in children: case-based update.
Tubbs RS, Muhleman M, Loukas M, Cohen-Gadol AA
Childs Nerv Syst 2012 Mar;28(3):345-8. Epub 2011 Jul 22 doi: 10.1007/s00381-011-1530-x. PMID: 21779976
Cerebrospinal fluid eosinophilia associated with intraventricular shunts.
Bezerra S, Frigeri TM, Severo CM, Santana JC, Graeff-Teixeira C
Clin Neurol Neurosurg 2011 Jun;113(5):345-9. Epub 2011 Apr 13 doi: 10.1016/j.clineuro.2011.03.005. PMID: 21492998
Tissue adhesive and postoperative allergic meningitis.
Kitoh A, Arima Y, Nishigori C, Kikuta Ki, Miyachi Y
Lancet 2002 May 11;359(9318):1668-70. doi: 10.1016/s0140-6736(02)08558-6. PMID: 12020530
Cysticercosis update.
Grisolia JS
West J Med 1984 Jun;140(6):901-4. PMID: 6377706Free PMC Article

Prognosis

Treatment of recurrent ventriculoperitoneal shunt failure associated with persistent cerebrospinal fluid eosinophilia and latex allergy by use of an "extracted" shunt.
Ellis MJ, Kazina CJ, Del Bigio MR, McDonald PJ
J Neurosurg Pediatr 2008 Mar;1(3):237-9. doi: 10.3171/PED/2008/1/3/237. PMID: 18352769
Early diagnosis of ventriculoperitoneal shunt infections and malfunctions in children with hydrocephalus.
Lan CC, Wong TT, Chen SJ, Liang ML, Tang RB
J Microbiol Immunol Infect 2003 Mar;36(1):47-50. PMID: 12741733
Molecular monitoring of cerebrospinal fluid can predict clinical relapse in acute lymphoblastic leukemia with eosinophilia.
Nuñez CA, Zipf TF, Roberts WM, Medeiros LJ, Hayes K, Bueso-Ramos CE
Arch Pathol Lab Med 2003 May;127(5):601-5. doi: 10.5858/2003-127-0601-MMOCFC. PMID: 12708906
Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases.
Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM
Am J Med 2001 Aug;111(2):109-14. doi: 10.1016/s0002-9343(01)00766-5. PMID: 11498063
Ventricular cerebrospinal fluid eosinophilia in children with ventriculoperitoneal shunts.
Tung H, Raffel C, McComb JG
J Neurosurg 1991 Oct;75(4):541-4. doi: 10.3171/jns.1991.75.4.0541. PMID: 1885971

Clinical prediction guides

Cerebrospinal fluid eosinophilia in a child with neuroborreliosis.
Buda P, Zawadka K, Wadowska-Kłopotek W, Smorczewska-Kiljan A, Wieteska-Klimczak A, Marczyńska M, Książyk J
Wiad Lek 2015;68(1):92-4. PMID: 26094340
Early diagnosis of ventriculoperitoneal shunt infections and malfunctions in children with hydrocephalus.
Lan CC, Wong TT, Chen SJ, Liang ML, Tang RB
J Microbiol Immunol Infect 2003 Mar;36(1):47-50. PMID: 12741733
Molecular monitoring of cerebrospinal fluid can predict clinical relapse in acute lymphoblastic leukemia with eosinophilia.
Nuñez CA, Zipf TF, Roberts WM, Medeiros LJ, Hayes K, Bueso-Ramos CE
Arch Pathol Lab Med 2003 May;127(5):601-5. doi: 10.5858/2003-127-0601-MMOCFC. PMID: 12708906

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