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Elevated urine D-lactate level

MedGen UID:
1054181
Concept ID:
CN377299
Finding
Synonym: https://github.com/obophenotype/human-phenotype-ontology/issues/8641
 
HPO: HP:6000467

Definition

The amount of D-lactate in the urine, normalized for urine concentration, is above the upper limit of normal. L-lactate is a familiar molecule to the human body and is also produced in large amounts in human tissues, depending on metabolic conditions. In contrast, D-lactate is produced only in minute quantities in human tissues, and is therefore not detectable in the bloodstream under normal physiological conditions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urine D-lactate level

Conditions with this feature

Lactic aciduria due to D-lactic acid
MedGen UID:
1679270
Concept ID:
C5193006
Disease or Syndrome
D-lactic aciduria is characterized by elevated D-lactate in plasma and urine. Patients show elevated serum uric acid concentrations and low urinary uric acid levels, due to reduced renal clearance of uric acid, and affected adults may experience episodes of gouty arthropathy (Drabkin et al., 2019). For a discussion of genetic heterogeneity of serum uric acid concentration quantitative trait loci, see UAQTL1 (138900).

Recent clinical studies

Etiology

Wisén E, Almazrooa A, Sand Bown L, Rizell M, Ricksten SE, Kvarnström A, Svennerholm K
Acta Anaesthesiol Scand 2021 Aug;65(7):886-894. Epub 2021 Apr 16 doi: 10.1111/aas.13823. PMID: 33811772
Chou CK, Lee YT, Chen SM, Hsieh CW, Huang TC, Li YC, Lee JA
J Pharm Biomed Anal 2015 Dec 10;116:65-70. Epub 2015 Jun 12 doi: 10.1016/j.jpba.2015.06.014. PMID: 26166004

Diagnosis

Wisén E, Almazrooa A, Sand Bown L, Rizell M, Ricksten SE, Kvarnström A, Svennerholm K
Acta Anaesthesiol Scand 2021 Aug;65(7):886-894. Epub 2021 Apr 16 doi: 10.1111/aas.13823. PMID: 33811772
Chou CK, Lee YT, Chen SM, Hsieh CW, Huang TC, Li YC, Lee JA
J Pharm Biomed Anal 2015 Dec 10;116:65-70. Epub 2015 Jun 12 doi: 10.1016/j.jpba.2015.06.014. PMID: 26166004
Henry H, Marmy Conus N, Steenhout P, Béguin A, Boulat O
Biomed Chromatogr 2012 Apr;26(4):425-8. Epub 2011 Aug 12 doi: 10.1002/bmc.1681. PMID: 21842515
Lord RS, Bralley JA
Altern Med Rev 2008 Dec;13(4):292-306. PMID: 19152477
Tailor P, Raman T, Garganta CL, Njalsson R, Carlsson K, Ristoff E, Carey HB
Am J Kidney Dis 2005 Jul;46(1):e4-10. doi: 10.1053/j.ajkd.2005.03.021. PMID: 15983950

Therapy

Tailor P, Raman T, Garganta CL, Njalsson R, Carlsson K, Ristoff E, Carey HB
Am J Kidney Dis 2005 Jul;46(1):e4-10. doi: 10.1053/j.ajkd.2005.03.021. PMID: 15983950
Karton MA, Rettmer R, Lipkin EW, Ott SM, Chait A
JPEN J Parenter Enteral Nutr 1989 Mar-Apr;13(2):132-5. doi: 10.1177/0148607189013002132. PMID: 2496243
Ramakrishnan T, Stokes P
JPEN J Parenter Enteral Nutr 1985 May-Jun;9(3):361-3. doi: 10.1177/0148607185009003361. PMID: 4009922

Clinical prediction guides

Wisén E, Almazrooa A, Sand Bown L, Rizell M, Ricksten SE, Kvarnström A, Svennerholm K
Acta Anaesthesiol Scand 2021 Aug;65(7):886-894. Epub 2021 Apr 16 doi: 10.1111/aas.13823. PMID: 33811772
Henry H, Marmy Conus N, Steenhout P, Béguin A, Boulat O
Biomed Chromatogr 2012 Apr;26(4):425-8. Epub 2011 Aug 12 doi: 10.1002/bmc.1681. PMID: 21842515

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