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Elevated CSF 14-3-3 protein concentration

MedGen UID:
1053956
•Concept ID:
CN377518
•
Finding
HPO: HP:6000689

Definition

The concentration of 14-3-3 protein in the cerebrospinal fluid (CSF) is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated CSF 14-3-3 protein concentration

Professional guidelines

PubMed

Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer's Disease.
Hermann P, Haller P, Goebel S, Bunck T, Schmidt C, Wiltfang J, Zerr I
Viruses 2022 Jan 28;14(2) doi: 10.3390/v14020276. PMID: 35215868Free PMC Article

Recent clinical studies

Etiology

Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer's Disease.
Hermann P, Haller P, Goebel S, Bunck T, Schmidt C, Wiltfang J, Zerr I
Viruses 2022 Jan 28;14(2) doi: 10.3390/v14020276. PMID: 35215868Free PMC Article
TREM2 expression in the brain and biological fluids in prion diseases.
Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, Zetterberg H, Blennow K, Del Río JA, Marín-Moreno A, Espinosa JC, Torres JM, Sánchez-Valle R, Mollenhauer B, Ferrer I, Zerr I, Llorens F
Acta Neuropathol 2021 Jun;141(6):841-859. Epub 2021 Apr 21 doi: 10.1007/s00401-021-02296-1. PMID: 33881612Free PMC Article
Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Kasai T, Tokuda T, Ishii R, Ishigami N, Tsuboi Y, Nakagawa M, Mizuno T, El-Agnaf OM
J Neurol 2014 Jun;261(6):1203-9. Epub 2014 Apr 16 doi: 10.1007/s00415-014-7334-7. PMID: 24737170
14-3-3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection.
Tsai HC, Huang YL, Chen YS, Yen CM, Tsai R, Lee SS, Tai MH
BMC Res Notes 2014 Feb 20;7:97. doi: 10.1186/1756-0500-7-97. PMID: 24555778Free PMC Article

Diagnosis

Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer's Disease.
Hermann P, Haller P, Goebel S, Bunck T, Schmidt C, Wiltfang J, Zerr I
Viruses 2022 Jan 28;14(2) doi: 10.3390/v14020276. PMID: 35215868Free PMC Article
TREM2 expression in the brain and biological fluids in prion diseases.
Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, Zetterberg H, Blennow K, Del Río JA, Marín-Moreno A, Espinosa JC, Torres JM, Sánchez-Valle R, Mollenhauer B, Ferrer I, Zerr I, Llorens F
Acta Neuropathol 2021 Jun;141(6):841-859. Epub 2021 Apr 21 doi: 10.1007/s00401-021-02296-1. PMID: 33881612Free PMC Article
Regulation of human cerebrospinal fluid malate dehydrogenase 1 in sporadic Creutzfeldt-Jakob disease patients.
Schmitz M, Llorens F, Pracht A, Thom T, Correia Â, Zafar S, Ferrer I, Zerr I
Aging (Albany NY) 2016 Nov 14;8(11):2927-2935. doi: 10.18632/aging.101101. PMID: 27852982Free PMC Article
Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic.
Schmitz M, Ebert E, Stoeck K, Karch A, Collins S, Calero M, Sklaviadis T, Laplanche JL, Golanska E, Baldeiras I, Satoh K, Sanchez-Valle R, Ladogana A, Skinningsrud A, Hammarin AL, Mitrova E, Llorens F, Kim YS, Green A, Zerr I
Mol Neurobiol 2016 May;53(4):2189-99. Epub 2015 May 7 doi: 10.1007/s12035-015-9167-5. PMID: 25947081
Increased α-synuclein levels in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.
Kasai T, Tokuda T, Ishii R, Ishigami N, Tsuboi Y, Nakagawa M, Mizuno T, El-Agnaf OM
J Neurol 2014 Jun;261(6):1203-9. Epub 2014 Apr 16 doi: 10.1007/s00415-014-7334-7. PMID: 24737170

Prognosis

Tau protein and 14-3-3 are elevated in the cerebrospinal fluid of patients with multiple sclerosis and correlate with intrathecal synthesis of IgG.
Bartosik-Psujek H, Archelos JJ
J Neurol 2004 Apr;251(4):414-20. doi: 10.1007/s00415-004-0336-0. PMID: 15083285

Clinical prediction guides

Total and Phosphorylated Cerebrospinal Fluid Tau in the Differential Diagnosis of Sporadic Creutzfeldt-Jakob Disease and Rapidly Progressive Alzheimer's Disease.
Hermann P, Haller P, Goebel S, Bunck T, Schmidt C, Wiltfang J, Zerr I
Viruses 2022 Jan 28;14(2) doi: 10.3390/v14020276. PMID: 35215868Free PMC Article
Tau protein and 14-3-3 are elevated in the cerebrospinal fluid of patients with multiple sclerosis and correlate with intrathecal synthesis of IgG.
Bartosik-Psujek H, Archelos JJ
J Neurol 2004 Apr;251(4):414-20. doi: 10.1007/s00415-004-0336-0. PMID: 15083285

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