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Decreased circulating thrombopoietin concentration

MedGen UID:
1053631
•Concept ID:
CN376536
•
Finding
HPO: HP:6000021

Definition

Concentration of thrombopoietin in the blood circulation below the lower limit of normal. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney that stimulates the production and differentiation of megakaryocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating thrombopoietin concentration

Professional guidelines

PubMed

Development of Romiplostim for Treatment of Primary Immune Thrombocytopenia From a Pharmacokinetic and Pharmacodynamic Perspective.
Yang BB, Doshi S, Arkam K, Franklin J, Chow AT
Clin Pharmacokinet 2016 Sep;55(9):1045-58. doi: 10.1007/s40262-016-0382-7. PMID: 27056734

Recent clinical studies

Etiology

Laboratory Markers of Platelet Production and Turnover.
Bodrova VV, Shustova ON, Khaspekova SG, Mazurov AV
Biochemistry (Mosc) 2023 Jan;88(Suppl 1):S39-S51. doi: 10.1134/S0006297923140031. PMID: 37069113
Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
The Levels of Circulating Proangiogenic Factors in Migraineurs.
Michalak S, Kalinowska-Lyszczarz A, Wegrzyn D, Thielemann A, Osztynowicz K, Kozubski W
Neuromolecular Med 2017 Dec;19(4):510-517. Epub 2017 Sep 16 doi: 10.1007/s12017-017-8465-7. PMID: 28918499Free PMC Article
Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis, and its relationship with circulating thrombocyte counts.
Koruk M, Onuk MD, Akçay F, Savas MC
Hepatogastroenterology 2002 Nov-Dec;49(48):1645-8. PMID: 12397754
Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.
Prchal JT
Semin Hematol 2001 Jan;38(1 Suppl 2):10-20. doi: 10.1016/s0037-1963(01)90135-0. PMID: 11242597

Diagnosis

Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Serum thrombopoietin level after allogeneic bone marrow transplantation: possible correlations with platelet recovery, acute graft-versus-host disease and hepatic veno-occlusive disease. Nagoya Bone Marrow Transplantation Group.
Hamaguchi M, Yamada H, Morishima Y, Morishita Y, Kato Y, Sao H, Kanie T, Murata M, Taji H, Nakayama Y, Minami S, Saito H, Kodera Y
Int J Hematol 1996 Oct;64(3-4):241-8. doi: 10.1016/0925-5710(96)00487-2. PMID: 8923786

Therapy

Development of Romiplostim for Treatment of Primary Immune Thrombocytopenia From a Pharmacokinetic and Pharmacodynamic Perspective.
Yang BB, Doshi S, Arkam K, Franklin J, Chow AT
Clin Pharmacokinet 2016 Sep;55(9):1045-58. doi: 10.1007/s40262-016-0382-7. PMID: 27056734
Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside.
Deutsch VR, Tomer A
Br J Haematol 2013 Jun;161(6):778-93. Epub 2013 Apr 18 doi: 10.1111/bjh.12328. PMID: 23594368
Megakaryocyte development and platelet production.
Deutsch VR, Tomer A
Br J Haematol 2006 Sep;134(5):453-66. doi: 10.1111/j.1365-2141.2006.06215.x. PMID: 16856888
In vivo expansion of the circulating stem cell pool.
Körbling M
Stem Cells 1998;16 Suppl 1:131-8. doi: 10.1002/stem.5530160816. PMID: 11012155
Serum thrombopoietin and interleukin 6 concentrations in tumour patients and response to chemotherapy-induced thrombocytopenia.
Heits F, Katschinski DM, Wilmsen U, Wiedemann GJ, Jelkmann W
Eur J Haematol 1997 Jul;59(1):53-8. doi: 10.1111/j.1600-0609.1997.tb00959.x. PMID: 9260581

Prognosis

Thrombopoietin participates in platelet activation in COVID-19 patients.
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Endogenous serum thrombopoietin concentrations in patients with myelodysplastic syndromes.
Zwierzina H, Rollinger-Holzinger I, Nuessler V, Herold M, Meng YG
Leukemia 1998 Jan;12(1):59-64. doi: 10.1038/sj.leu.2400901. PMID: 9436921

Clinical prediction guides

Laboratory Markers of Platelet Production and Turnover.
Bodrova VV, Shustova ON, Khaspekova SG, Mazurov AV
Biochemistry (Mosc) 2023 Jan;88(Suppl 1):S39-S51. doi: 10.1134/S0006297923140031. PMID: 37069113
The Levels of Circulating Proangiogenic Factors in Migraineurs.
Michalak S, Kalinowska-Lyszczarz A, Wegrzyn D, Thielemann A, Osztynowicz K, Kozubski W
Neuromolecular Med 2017 Dec;19(4):510-517. Epub 2017 Sep 16 doi: 10.1007/s12017-017-8465-7. PMID: 28918499Free PMC Article
Development of Romiplostim for Treatment of Primary Immune Thrombocytopenia From a Pharmacokinetic and Pharmacodynamic Perspective.
Yang BB, Doshi S, Arkam K, Franklin J, Chow AT
Clin Pharmacokinet 2016 Sep;55(9):1045-58. doi: 10.1007/s40262-016-0382-7. PMID: 27056734
Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis.
Cuccurullo A, Greco E, Lupia E, De Giuli P, Bosco O, Martin-Conte E, Spatola T, Turco E, Montrucchio G
PLoS One 2016;11(3):e0151088. Epub 2016 Mar 10 doi: 10.1371/journal.pone.0151088. PMID: 26963510Free PMC Article
Circasemidian rather than circadian variation of circulating osteoprotegerin in clinical health.
Tarquini R, Mazzoccoli G, Dolenti S, Gaudiano P, Comuni C, Laffi G, Perfetto F, Otsuka K, Cornélissen G, Halberg F
Biomed Pharmacother 2005 Oct;59 Suppl 1(Suppl 1):S225-8. doi: 10.1016/s0753-3322(05)80036-8. PMID: 16275499Free PMC Article

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