U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mosaic attenuation pattern in lung

MedGen UID:
1053585
•Concept ID:
CN377126
•
Finding
HPO: HP:6000317

Definition

Mosaic attenuation pattern in the lung is a term used to describe regions of differing pulmonary attenuation on CT imaging. It is a non-specific finding, although is associated with several conditions such as obstructive small airway disease, occlusive vascular disease (in which case is called mosaic perfusion pattern), pulmonary edema, and parenchymal diseases. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMosaic attenuation pattern in lung

Professional guidelines

PubMed

HRCT findings in the lungs of primary care patients with lower respiratory tract infection.
Lähde S, Jartti A, Broas M, Koivisto M, Syrjälä H
Acta Radiol 2002 Mar;43(2):159-63. doi: 10.1080/028418502127347673. PMID: 12010295

Recent clinical studies

Etiology

HRCT findings in secondhand smokers with respiratory symptoms.
Detorakis EE, Lasithiotaki I, Dailiani K, Raissaki M
Jpn J Radiol 2023 Feb;41(2):153-163. Epub 2022 Sep 19 doi: 10.1007/s11604-022-01336-4. PMID: 36121625
Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
Gayá García-Manso I, Arenas-Jiménez J, García-Sevila R, Ruiz-Alcaraz S, Sirera-Matilla M, García-Garrigós E, Martínez-García MÁ, Hernández-Blasco L
Sci Rep 2022 May 4;12(1):7289. doi: 10.1038/s41598-022-10750-7. PMID: 35508493Free PMC Article
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension.
Fernandes CJCDS, de Oliveira EP, Salibe-Filho W, Terra-Filho M, Jardim CVP, Kato-Morinaga LT, Hoette S, de Souza R
Clinics (Sao Paulo) 2020;75:e1373. Epub 2020 Jan 10 doi: 10.6061/clinics/2020/e1373. PMID: 31939560Free PMC Article
Pulmonary interstitial glycogenosis - A systematic analysis of new cases.
Seidl E, Carlens J, Reu S, Wetzke M, Ley-Zaporozhan J, Brasch F, Wesselak T, Schams A, Rauch D, Schuch L, Kappler M, Schelstraete P, Wolf M, Stehling F, Haarmann E, Borensztajn D, van de Loo M, Rubak S, Lex C, Hinrichs B, Reiter K, Schwerk N, Griese M
Respir Med 2018 Jul;140:11-20. Epub 2018 May 17 doi: 10.1016/j.rmed.2018.05.009. PMID: 29957271
Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445

Diagnosis

Mosaic Attenuation Pattern: A Guide to Analysis with HRCT.
Lee GM, Carroll MB, Galvin JR, Walker CM
Radiol Clin North Am 2022 Nov;60(6):963-978. Epub 2022 Sep 3 doi: 10.1016/j.rcl.2022.06.009. PMID: 36202482
Overview and Challenges of Bronchiolar Disorders.
Swaminathan AC, Carney JM, Tailor TD, Palmer SM
Ann Am Thorac Soc 2020 Mar;17(3):253-263. doi: 10.1513/AnnalsATS.201907-569CME. PMID: 31860801
Diffuse Neuroendocrine Hyperplasia with Obliterative Bronchiolitis and Usual Interstitial Pneumonia: An Unusual "Headcheese Pattern" with Nodules.
Pietrangeli V, Piciucchi S, Tomassetti S, Ravaglia C, Gurioli C, Gurioli Ch, Cavazza A, Dubini A, Poletti V
Lung 2015 Dec;193(6):1051-4. Epub 2015 Oct 7 doi: 10.1007/s00408-015-9817-4. PMID: 26446675
Mosaic Attenuation: Etiology, Methods of Differentiation, and Pitfalls.
Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR
Radiographics 2015 Sep-Oct;35(5):1360-80. Epub 2015 Aug 14 doi: 10.1148/rg.2015140308. PMID: 26274445
Imaging appearances of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.
Foran PJ, Hayes SA, Blair DJ, Zakowski MF, Ginsberg MS
Clin Imaging 2015 Mar-Apr;39(2):243-6. Epub 2014 Oct 30 doi: 10.1016/j.clinimag.2014.10.017. PMID: 25496668

Therapy

HRCT findings in secondhand smokers with respiratory symptoms.
Detorakis EE, Lasithiotaki I, Dailiani K, Raissaki M
Jpn J Radiol 2023 Feb;41(2):153-163. Epub 2022 Sep 19 doi: 10.1007/s11604-022-01336-4. PMID: 36121625
Lung Cavities in Chronic Thromboembolic Pulmonary Hypertension.
Fernandes CJCDS, de Oliveira EP, Salibe-Filho W, Terra-Filho M, Jardim CVP, Kato-Morinaga LT, Hoette S, de Souza R
Clinics (Sao Paulo) 2020;75:e1373. Epub 2020 Jan 10 doi: 10.6061/clinics/2020/e1373. PMID: 31939560Free PMC Article
Pulmonary interstitial glycogenosis - A systematic analysis of new cases.
Seidl E, Carlens J, Reu S, Wetzke M, Ley-Zaporozhan J, Brasch F, Wesselak T, Schams A, Rauch D, Schuch L, Kappler M, Schelstraete P, Wolf M, Stehling F, Haarmann E, Borensztajn D, van de Loo M, Rubak S, Lex C, Hinrichs B, Reiter K, Schwerk N, Griese M
Respir Med 2018 Jul;140:11-20. Epub 2018 May 17 doi: 10.1016/j.rmed.2018.05.009. PMID: 29957271
Invasive airway aspergillosis with new airflow obstruction mimicking post-BMT bronchiolitis obliterans.
Nusair S, Amir G, Or R, Breuer R
Bone Marrow Transplant 2002 Apr;29(8):711-3. doi: 10.1038/sj.bmt.1703553. PMID: 12180119
Clinical spectrum of adult chronic bronchiolitis.
Poletti V, Zompatori M, Cancellieri A
Sarcoidosis Vasc Diffuse Lung Dis 1999 Sep;16(2):183-96. PMID: 10560122

Prognosis

Incidental pulmonary nodules in children: characteristic features and clinical course.
Başaran A, Başaran AE, Keven A, Elmalı A, Durmuş SY, Kazlı T, Kocacık-Uygun DF, Bingöl A
Turk J Pediatr 2022;64(3):466-473. doi: 10.24953/turkjped.2021.4858. PMID: 35899559
Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
Gayá García-Manso I, Arenas-Jiménez J, García-Sevila R, Ruiz-Alcaraz S, Sirera-Matilla M, García-Garrigós E, Martínez-García MÁ, Hernández-Blasco L
Sci Rep 2022 May 4;12(1):7289. doi: 10.1038/s41598-022-10750-7. PMID: 35508493Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Presence of Air Trapping and Mosaic Attenuation on Chest Computed Tomography Predicts Survival in Chronic Hypersensitivity Pneumonitis.
Chung JH, Zhan X, Cao M, Koelsch TL, Manjarres DCG, Brown KK, Lynch DA, Russell G, Fernández Pérez ER
Ann Am Thorac Soc 2017 Oct;14(10):1533-1538. doi: 10.1513/AnnalsATS.201701-035OC. PMID: 28513215
Invasive airway aspergillosis with new airflow obstruction mimicking post-BMT bronchiolitis obliterans.
Nusair S, Amir G, Or R, Breuer R
Bone Marrow Transplant 2002 Apr;29(8):711-3. doi: 10.1038/sj.bmt.1703553. PMID: 12180119

Clinical prediction guides

Incidental pulmonary nodules in children: characteristic features and clinical course.
Başaran A, Başaran AE, Keven A, Elmalı A, Durmuş SY, Kazlı T, Kocacık-Uygun DF, Bingöl A
Turk J Pediatr 2022;64(3):466-473. doi: 10.24953/turkjped.2021.4858. PMID: 35899559
Mosaic attenuation in non-fibrotic areas as a predictor of non-usual interstitial pneumonia pathologic diagnosis.
Gayá García-Manso I, Arenas-Jiménez J, García-Sevila R, Ruiz-Alcaraz S, Sirera-Matilla M, García-Garrigós E, Martínez-García MÁ, Hernández-Blasco L
Sci Rep 2022 May 4;12(1):7289. doi: 10.1038/s41598-022-10750-7. PMID: 35508493Free PMC Article
Air trapping in COVID-19 patients following hospital discharge: retrospective evaluation with paired inspiratory/expiratory thin-section CT.
Franquet T, Giménez A, Ketai L, Mazzini S, Rial A, Pomar V, Domingo P
Eur Radiol 2022 Jul;32(7):4427-4436. Epub 2022 Feb 28 doi: 10.1007/s00330-022-08580-2. PMID: 35226158Free PMC Article
Forced Oscillation Technique and Small Airway Involvement in Chronic Hypersensitivity Pneumonitis.
Dias OM, Baldi BG, Chate RC, Ribeiro de Carvalho CR, Dellacà RL, Milesi I, Pereira de Albuquerque AL
Arch Bronconeumol (Engl Ed) 2019 Oct;55(10):519-525. Epub 2019 Apr 8 doi: 10.1016/j.arbres.2019.01.022. PMID: 30975515
Presence of Air Trapping and Mosaic Attenuation on Chest Computed Tomography Predicts Survival in Chronic Hypersensitivity Pneumonitis.
Chung JH, Zhan X, Cao M, Koelsch TL, Manjarres DCG, Brown KK, Lynch DA, Russell G, Fernández Pérez ER
Ann Am Thorac Soc 2017 Oct;14(10):1533-1538. doi: 10.1513/AnnalsATS.201701-035OC. PMID: 28513215

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...