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Positive CSF infectious agent test

MedGen UID:
1053212
•Concept ID:
CN377066
•
Finding
HPO: HP:0430123

Definition

Any kind of test for an infectious agent in the cerebrospinal fluid (CSF) positive. [from HPO]

Professional guidelines

PubMed

Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.
Zhuang W, He T, Tuerheng J, He G, Wang BL, Yang YH, Zhang L, Dong XZ, Xi SY
BMC Infect Dis 2024 May 10;24(1):485. doi: 10.1186/s12879-024-09308-x. PMID: 38730327Free PMC Article
Consensus statement on childhood tuberculosis.
Working Group on Tuberculosis, Indian Academy of Pediatrics (IAP)
Indian Pediatr 2010 Jan;47(1):41-55. doi: 10.1007/s13312-010-0008-3. PMID: 20139477
Differential diagnosis and clinical course of autoimmune neutropenia in infancy: comparison with congenital neutropenia.
Taniuchi S, Masuda M, Hasui M, Tsuji S, Takahashi H, Kobayashi Y
Acta Paediatr 2002;91(11):1179-82. doi: 10.1080/080352502320777405. PMID: 12463315

Recent clinical studies

Etiology

Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.
Zhuang W, He T, Tuerheng J, He G, Wang BL, Yang YH, Zhang L, Dong XZ, Xi SY
BMC Infect Dis 2024 May 10;24(1):485. doi: 10.1186/s12879-024-09308-x. PMID: 38730327Free PMC Article
Varicella zoster virus infection in neurological patients in Bulgaria.
Shikova E, Kumanova A, Tournev I, Zhelyazkova S, Vassileva E, Ivanov I, Pishmisheva M
J Neurovirol 2021 Apr;27(2):272-278. Epub 2021 Mar 4 doi: 10.1007/s13365-021-00952-6. PMID: 33661458
Positive Impact of Routine Testing for Enterovirus and Parechovirus on Length of Hospitalization and Antimicrobial Use among Inpatients ≤6 Months of Age.
Lee BR, Sasidharan A, Harrison CJ, Selvarangan R
J Clin Microbiol 2020 Dec 17;59(1) doi: 10.1128/JCM.02106-20. PMID: 33055181Free PMC Article
Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives.
Talagrand-Reboul E, Raffetin A, Zachary P, Jaulhac B, Eldin C
Front Cell Infect Microbiol 2020;10:241. Epub 2020 May 19 doi: 10.3389/fcimb.2020.00241. PMID: 32509603Free PMC Article
Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients.
Landi C, Santinelli L, Bianchi L, Shaba E, Ceccarelli G, Cavallari EN, Borrazzo C, Pinacchio C, Scagnolari C, Vullo V, Bini L, d'Ettorre G
J Neurovirol 2020 Feb;26(1):95-106. Epub 2019 Nov 1 doi: 10.1007/s13365-019-00801-7. PMID: 31677067

Diagnosis

Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.
Zhuang W, He T, Tuerheng J, He G, Wang BL, Yang YH, Zhang L, Dong XZ, Xi SY
BMC Infect Dis 2024 May 10;24(1):485. doi: 10.1186/s12879-024-09308-x. PMID: 38730327Free PMC Article
Comparison of bacterial culture with BioFire® FilmArray® multiplex PCR screening of archived cerebrospinal fluid specimens from children with suspected bacterial meningitis in Nigeria.
Obaro S, Hassan-Hanga F, Medugu N, Olaosebikan R, Olanipekun G, Jibir B, Gambo S, Ajose T, Duru C, Ebruke B, Davies HD
BMC Infect Dis 2023 Oct 2;23(1):641. doi: 10.1186/s12879-023-08645-7. PMID: 37784010Free PMC Article
Neuroimaging of central nervous system tuberculosis.
Morais CG, Reis-Melo A, Oliveira J, Ribeiro A, Pinto-Carvalho I, Tavares M
Acta Neurol Taiwan 2023 Jun 30;32(2):86-87. PMID: 37198514
Evaluation of the Novel CE-IVD-Marked Multiplex PCR QIAstat-Dx Meningitis/Encephalitis Panel.
Humisto A, Antikainen J, Holma T, Jarva H, Toivonen A, Loginov R, Mannonen L
Microbiol Spectr 2023 Jun 15;11(3):e0514422. Epub 2023 Apr 12 doi: 10.1128/spectrum.05144-22. PMID: 37042772Free PMC Article
Immunoserological Diagnosis of Human Borrelioses: Current Knowledge and Perspectives.
Talagrand-Reboul E, Raffetin A, Zachary P, Jaulhac B, Eldin C
Front Cell Infect Microbiol 2020;10:241. Epub 2020 May 19 doi: 10.3389/fcimb.2020.00241. PMID: 32509603Free PMC Article

Therapy

Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.
Zhuang W, He T, Tuerheng J, He G, Wang BL, Yang YH, Zhang L, Dong XZ, Xi SY
BMC Infect Dis 2024 May 10;24(1):485. doi: 10.1186/s12879-024-09308-x. PMID: 38730327Free PMC Article
Neuroimaging of central nervous system tuberculosis.
Morais CG, Reis-Melo A, Oliveira J, Ribeiro A, Pinto-Carvalho I, Tavares M
Acta Neurol Taiwan 2023 Jun 30;32(2):86-87. PMID: 37198514
Clinical, radiological and laboratory characteristics of central nervous system histoplasmosis: A systematic review of a severe disease.
de Oliveira VF, Kruschewsky WLL, Sekiguchi WK, Costa SF, Levin AS, Magri MMC, Silva GD
Mycoses 2023 Aug;66(8):659-670. Epub 2023 May 3 doi: 10.1111/myc.13600. PMID: 37132403
Positive Impact of Routine Testing for Enterovirus and Parechovirus on Length of Hospitalization and Antimicrobial Use among Inpatients ≤6 Months of Age.
Lee BR, Sasidharan A, Harrison CJ, Selvarangan R
J Clin Microbiol 2020 Dec 17;59(1) doi: 10.1128/JCM.02106-20. PMID: 33055181Free PMC Article
Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients.
Landi C, Santinelli L, Bianchi L, Shaba E, Ceccarelli G, Cavallari EN, Borrazzo C, Pinacchio C, Scagnolari C, Vullo V, Bini L, d'Ettorre G
J Neurovirol 2020 Feb;26(1):95-106. Epub 2019 Nov 1 doi: 10.1007/s13365-019-00801-7. PMID: 31677067

Prognosis

Neurobrucellosis: laboratory features, clinical characteristics, antibiotic treatment, and clinical outcomes of 21 patients.
Zhuang W, He T, Tuerheng J, He G, Wang BL, Yang YH, Zhang L, Dong XZ, Xi SY
BMC Infect Dis 2024 May 10;24(1):485. doi: 10.1186/s12879-024-09308-x. PMID: 38730327Free PMC Article
Clinical features to distinguish meningitis among young infants at a rural Kenyan hospital.
Obiero CW, Mturi N, Mwarumba S, Ngari M, Newton C, Boele van Hensbroek M, Berkley JA
Arch Dis Child 2021 Feb;106(2):130-136. Epub 2020 Aug 20 doi: 10.1136/archdischild-2020-318913. PMID: 32819909Free PMC Article
Elevated inflammatory cytokines in aqueous cytokine profile in HIV-1 infected patients with cataracts in Uganda.
Otiti-Sengeri J, Colebunders R, Reynolds SJ, Muwonge M, Nakigozi G, Kiggundu V, Nalugoda F, Nakanjako D
BMC Ophthalmol 2018 Jan 19;18(1):12. doi: 10.1186/s12886-018-0680-y. PMID: 29351788Free PMC Article
Diagnostic Value of CRP, Procalcitonin, and Ferritin Levels in Cerebrospinal Fluid of Children with Meningitis.
Shokrollahi MR, Shabanzadeh K, Noorbakhsh S, Tabatabaei A, Movahedi Z, Shamshiri AR
Cent Nerv Syst Agents Med Chem 2018 Jan 26;18(1):58-62. doi: 10.2174/1871524916666160302103223. PMID: 26931764
Severe invasive listeriosis--case report.
Teodor A, Teodor D, Miftode E, Prisăcaru D, Leca D, Petrovici C, Dorneanu O, Dorobăt CM
Rev Med Chir Soc Med Nat Iasi 2012 Jul-Sep;116(3):808-11. PMID: 23272533

Clinical prediction guides

Clinical characteristics, diagnosis, and predictors of neurosyphilis patients with human immunodeficiency virus co-infection: A retrospective study at infectious diseases hospitals in two cities of China.
Yu J, Shi J, Wan H, Li J, Shao Y, Ye J, Dai L, Wang X, Liu A
Medicine (Baltimore) 2021 Oct 22;100(42):e27430. doi: 10.1097/MD.0000000000027430. PMID: 34678871Free PMC Article
Clinical features to distinguish meningitis among young infants at a rural Kenyan hospital.
Obiero CW, Mturi N, Mwarumba S, Ngari M, Newton C, Boele van Hensbroek M, Berkley JA
Arch Dis Child 2021 Feb;106(2):130-136. Epub 2020 Aug 20 doi: 10.1136/archdischild-2020-318913. PMID: 32819909Free PMC Article
Positive Impact of Routine Testing for Enterovirus and Parechovirus on Length of Hospitalization and Antimicrobial Use among Inpatients ≤6 Months of Age.
Lee BR, Sasidharan A, Harrison CJ, Selvarangan R
J Clin Microbiol 2020 Dec 17;59(1) doi: 10.1128/JCM.02106-20. PMID: 33055181Free PMC Article
Cognitive impairment and CSF proteome modification after oral bacteriotherapy in HIV patients.
Landi C, Santinelli L, Bianchi L, Shaba E, Ceccarelli G, Cavallari EN, Borrazzo C, Pinacchio C, Scagnolari C, Vullo V, Bini L, d'Ettorre G
J Neurovirol 2020 Feb;26(1):95-106. Epub 2019 Nov 1 doi: 10.1007/s13365-019-00801-7. PMID: 31677067
Epidemiological and clinical characteristics of neurobrucellosis case patients in Tunisia.
Oueslati I, Berriche A, Ammari L, Abdelmalek R, Kanoun F, Kilani B, Tiouiri Benaissa H
Med Mal Infect 2016 May;46(3):123-30. Epub 2016 Feb 17 doi: 10.1016/j.medmal.2016.01.005. PMID: 26897309

Recent systematic reviews

Clinical, radiological and laboratory characteristics of central nervous system histoplasmosis: A systematic review of a severe disease.
de Oliveira VF, Kruschewsky WLL, Sekiguchi WK, Costa SF, Levin AS, Magri MMC, Silva GD
Mycoses 2023 Aug;66(8):659-670. Epub 2023 May 3 doi: 10.1111/myc.13600. PMID: 37132403

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