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Anti-dachshund family transcription factor 1 antibody positivity

MedGen UID:
1053098
•Concept ID:
CN378023
•
Finding
Synonym: Anti-neuronal nuclear antibody-type 3 positivity
 
HPO: HP:6000877

Definition

The presence of autoantibodies in the serum that react against dachshund-homolog 1 (DACH1) autoantigen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-dachshund family transcription factor 1 antibody positivity

Professional guidelines

PubMed

An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.
Bhakta S, Crocker LM, Chen Y, Hazen M, Schutten MM, Li D, Kuijl C, Ohri R, Zhong F, Poon KA, Go MAT, Cheng E, Piskol R, Firestein R, Fourie-O'Donohue A, Kozak KR, Raab H, Hongo JA, Sampath D, Dennis MS, Scheller RH, Polakis P, Junutula JR
Mol Cancer Ther 2018 Mar;17(3):638-649. Epub 2017 Dec 27 doi: 10.1158/1535-7163.MCT-17-0813. PMID: 29282299
Differential Diagnosis of Meningeal SFT-HPC and Meningioma: Which Immunohistochemical Markers Should Be Used?
Macagno N, Figarella-Branger D, Mokthari K, Metellus P, Jouvet A, Vasiljevic A, Loundou A, Bouvier C
Am J Surg Pathol 2016 Feb;40(2):270-8. doi: 10.1097/PAS.0000000000000526. PMID: 26448189
Anti-CD137 antibodies in the treatment of autoimmune disease and cancer.
Mittler RS, Foell J, McCausland M, Strahotin S, Niu L, Bapat A, Hewes LB
Immunol Res 2004;29(1-3):197-208. doi: 10.1385/IR:29:1-3:197. PMID: 15181282

Recent clinical studies

Therapy

Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma.
Le Saux O, Ardin M, Berthet J, Barrin S, Bourhis M, Cinier J, Lounici Y, Treilleux I, Just PA, Bataillon G, Savoye AM, Mouret-Reynier MA, Coquan E, Derbel O, Jeay L, Bouizaguen S, Labidi-Galy I, Tabone-Eglinger S, Ferrari A, Thomas E, Ménétrier-Caux C, Tartour E, Galy-Fauroux I, Stern MH, Terme M, Caux C, Dubois B, Ray-Coquard I
Nat Commun 2024 Jul 16;15(1):5932. doi: 10.1038/s41467-024-47000-5. PMID: 39013886Free PMC Article
B7-H3 as a Therapeutic Target in Advanced Prostate Cancer.
Guo C, Figueiredo I, Gurel B, Neeb A, Seed G, Crespo M, Carreira S, Rekowski J, Buroni L, Welti J, Bogdan D, Gallagher L, Sharp A, Fenor de la Maza MD, Rescigno P, Westaby D, Chandran K, Riisnaes R, Ferreira A, Miranda S, Calì B, Alimonti A, Bressan S, Nguyen AHT, Shen MM, Hawley JE, Obradovic A, Drake CG, Bertan C, Baker C, Tunariu N, Yuan W, de Bono JS
Eur Urol 2023 Mar;83(3):224-238. Epub 2022 Sep 13 doi: 10.1016/j.eururo.2022.09.004. PMID: 36114082
Δ40p53 isoform up-regulates netrin-1/UNC5B expression and potentiates netrin-1 pro-oncogenic activity.
Sun Y, Manceau A, Frydman L, Cappuccio L, Neves D, Basso V, Wang H, Fombonne J, Maisse C, Mehlen P, Paradisi A
Proc Natl Acad Sci U S A 2021 Sep 7;118(36) doi: 10.1073/pnas.2103319118. PMID: 34470826Free PMC Article
IL-1β-Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up-regulating Programmed Death Ligand 1 and Colony-Stimulating Factor 1.
He Q, Liu M, Huang W, Chen X, Zhang B, Zhang T, Wang Y, Liu D, Xie M, Ji X, Sun M, Tian D, Xia L
Hepatology 2021 Dec;74(6):3174-3193. Epub 2021 Aug 27 doi: 10.1002/hep.32062. PMID: 34288020
Treating young adults with type 2 diabetes or monogenic diabetes.
Owen KR
Best Pract Res Clin Endocrinol Metab 2016 Jun;30(3):455-67. Epub 2016 May 27 doi: 10.1016/j.beem.2016.05.002. PMID: 27432078

Prognosis

Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma.
Le Saux O, Ardin M, Berthet J, Barrin S, Bourhis M, Cinier J, Lounici Y, Treilleux I, Just PA, Bataillon G, Savoye AM, Mouret-Reynier MA, Coquan E, Derbel O, Jeay L, Bouizaguen S, Labidi-Galy I, Tabone-Eglinger S, Ferrari A, Thomas E, Ménétrier-Caux C, Tartour E, Galy-Fauroux I, Stern MH, Terme M, Caux C, Dubois B, Ray-Coquard I
Nat Commun 2024 Jul 16;15(1):5932. doi: 10.1038/s41467-024-47000-5. PMID: 39013886Free PMC Article
HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression.
Liu D, Luo X, Xie M, Zhang T, Chen X, Zhang B, Sun M, Wang Y, Feng Y, Ji X, Li Y, Liu B, Huang W, Xia L
Cancer Sci 2022 Oct;113(10):3347-3361. Epub 2022 Aug 12 doi: 10.1111/cas.15494. PMID: 35848884Free PMC Article
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy.
Salmon AJ, Shavkunov AS, Miao Q, Jarjour NN, Keshari S, Esaulova E, Williams CD, Ward JP, Highsmith AM, Pineda JE, Taneja R, Chen K, Edelson BT, Gubin MM
Cancer Immunol Res 2022 May 3;10(5):597-611. doi: 10.1158/2326-6066.CIR-21-0129. PMID: 35181783Free PMC Article
IL-1β-Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up-regulating Programmed Death Ligand 1 and Colony-Stimulating Factor 1.
He Q, Liu M, Huang W, Chen X, Zhang B, Zhang T, Wang Y, Liu D, Xie M, Ji X, Sun M, Tian D, Xia L
Hepatology 2021 Dec;74(6):3174-3193. Epub 2021 Aug 27 doi: 10.1002/hep.32062. PMID: 34288020
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J
Autophagy 2021 Oct;17(10):3175-3195. Epub 2020 Oct 22 doi: 10.1080/15548627.2020.1826689. PMID: 32972302Free PMC Article

Clinical prediction guides

Immunomic longitudinal profiling of the NeoPembrOv trial identifies drivers of immunoresistance in high-grade ovarian carcinoma.
Le Saux O, Ardin M, Berthet J, Barrin S, Bourhis M, Cinier J, Lounici Y, Treilleux I, Just PA, Bataillon G, Savoye AM, Mouret-Reynier MA, Coquan E, Derbel O, Jeay L, Bouizaguen S, Labidi-Galy I, Tabone-Eglinger S, Ferrari A, Thomas E, Ménétrier-Caux C, Tartour E, Galy-Fauroux I, Stern MH, Terme M, Caux C, Dubois B, Ray-Coquard I
Nat Commun 2024 Jul 16;15(1):5932. doi: 10.1038/s41467-024-47000-5. PMID: 39013886Free PMC Article
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy.
Salmon AJ, Shavkunov AS, Miao Q, Jarjour NN, Keshari S, Esaulova E, Williams CD, Ward JP, Highsmith AM, Pineda JE, Taneja R, Chen K, Edelson BT, Gubin MM
Cancer Immunol Res 2022 May 3;10(5):597-611. doi: 10.1158/2326-6066.CIR-21-0129. PMID: 35181783Free PMC Article
The role of interleukin-33 in chronic rhinosinusitis.
Kim DK, Jin HR, Eun KM, Mo JH, Cho SH, Oh S, Cho D, Kim DW
Thorax 2017 Jul;72(7):635-645. Epub 2016 Nov 24 doi: 10.1136/thoraxjnl-2016-208772. PMID: 27885166
Activating transcription factor 2 in mesenchymal tumors.
Endo M, Su L, Nielsen TO
Hum Pathol 2014 Feb;45(2):276-84. Epub 2013 Nov 27 doi: 10.1016/j.humpath.2013.09.003. PMID: 24289970
Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy.
Ohnuki K, Umezono T, Abe M, Kobayashi T, Kato M, Miyauchi M, Yamamoto N, Kimura M, Toyoda M, Suzuki D
J Nephrol 2012 Mar-Apr;25(2):233-9. doi: 10.5301/JN.2011.8449. PMID: 21725924

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