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Decreased CSF N-acetylaspartic acid concentration

MedGen UID:
1053067
Concept ID:
CN377503
Finding
Synonyms: Decreased CSF N-acetylaspartate acid concentration; N-acetylaspartate absent in CSF
 
HPO: HP:6000674

Definition

Concentration of N-acetylaspartic acid in the cerebrospinal fluid below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased CSF N-acetylaspartic acid concentration

Professional guidelines

PubMed

Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article

Recent clinical studies

Etiology

Voevodskaya O, Sundgren PC, Strandberg O, Zetterberg H, Minthon L, Blennow K, Wahlund LO, Westman E, Hansson O; Swedish BioFINDER study group
Neurology 2016 May 10;86(19):1754-61. Epub 2016 Apr 15 doi: 10.1212/WNL.0000000000002672. PMID: 27164711Free PMC Article
Molina V, Sánchez J, Sanz J, Reig S, Benito C, Leal I, Sarramea F, Rebolledo R, Palomo T, Desco M
Eur Psychiatry 2007 Nov;22(8):505-12. Epub 2007 Sep 29 doi: 10.1016/j.eurpsy.2007.07.006. PMID: 17904824
Chang L, Ernst T, Witt MD, Ames N, Gaiefsky M, Miller E
Neuroimage 2002 Nov;17(3):1638-48. doi: 10.1006/nimg.2002.1254. PMID: 12414302
Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD
Brain 2002 Oct;125(Pt 10):2332-41. doi: 10.1093/brain/awf226. PMID: 12244089
Do KQ, Lauer CJ, Schreiber W, Zollinger M, Gutteck-Amsler U, Cuénod M, Holsboer F
J Neurochem 1995 Dec;65(6):2652-62. doi: 10.1046/j.1471-4159.1995.65062652.x. PMID: 7595563

Diagnosis

Port JD, Unal SS, Mrazek DA, Marcus SM
Psychiatry Res 2008 Feb 28;162(2):113-21. Epub 2007 Dec 31 doi: 10.1016/j.pscychresns.2007.08.004. PMID: 18164911
Molina V, Sánchez J, Sanz J, Reig S, Benito C, Leal I, Sarramea F, Rebolledo R, Palomo T, Desco M
Eur Psychiatry 2007 Nov;22(8):505-12. Epub 2007 Sep 29 doi: 10.1016/j.eurpsy.2007.07.006. PMID: 17904824
Teunissen CE, Dijkstra C, Polman C
Lancet Neurol 2005 Jan;4(1):32-41. doi: 10.1016/S1474-4422(04)00964-0. PMID: 15620855
Chang L, Ernst T, Witt MD, Ames N, Gaiefsky M, Miller E
Neuroimage 2002 Nov;17(3):1638-48. doi: 10.1006/nimg.2002.1254. PMID: 12414302
Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD
Brain 2002 Oct;125(Pt 10):2332-41. doi: 10.1093/brain/awf226. PMID: 12244089

Therapy

Gongvatana A, Harezlak J, Buchthal S, Daar E, Schifitto G, Campbell T, Taylor M, Singer E, Algers J, Zhong J, Brown M, McMahon D, So YT, Mi D, Heaton R, Robertson K, Yiannoutsos C, Cohen RA, Navia B; HIV Neuroimaging Consortium
J Neurovirol 2013 Jun;19(3):209-18. Epub 2013 Apr 24 doi: 10.1007/s13365-013-0162-1. PMID: 23613008Free PMC Article
Lentz MR, Degaonkar M, Mohamed MA, Kim H, Conant K, Halpern EF, Sacktor N, Barker PB, Pomper MG
J Neurovirol 2010 Oct;16(5):368-76. doi: 10.3109/13550284.2010.513029. PMID: 20839921Free PMC Article
Woermann FG, McLean MA, Bartlett PA, Barker GJ, Duncan JS
Brain 2001 Feb;124(Pt 2):427-36. doi: 10.1093/brain/124.2.427. PMID: 11157569
Chang L, Ernst T, Strickland T, Mehringer CM
Am J Psychiatry 1999 May;156(5):716-22. doi: 10.1176/ajp.156.5.716. PMID: 10327904
Maeda H, Furune S, Nomura K, Kitou O, Ando Y, Negoro T, Watanabe K
Neuropediatrics 1997 Oct;28(5):262-7. doi: 10.1055/s-2007-973711. PMID: 9413005

Prognosis

Kuroda H, Fujihara K, Mugikura S, Takahashi S, Kushimoto S, Aoki M
J Neurol Sci 2016 Jan 15;360:161-9. Epub 2015 Dec 7 doi: 10.1016/j.jns.2015.12.006. PMID: 26723994
Lentz MR, Degaonkar M, Mohamed MA, Kim H, Conant K, Halpern EF, Sacktor N, Barker PB, Pomper MG
J Neurovirol 2010 Oct;16(5):368-76. doi: 10.3109/13550284.2010.513029. PMID: 20839921Free PMC Article
Tsujikawa T, Yoneda M, Shimizu Y, Uematsu H, Toyooka M, Ikawa M, Kudo T, Okazawa H, Kuriyama M, Kimura H
Brain Dev 2010 Feb;32(2):143-9. Epub 2009 Jan 26 doi: 10.1016/j.braindev.2008.12.003. PMID: 19171446
Teunissen CE, Dijkstra C, Polman C
Lancet Neurol 2005 Jan;4(1):32-41. doi: 10.1016/S1474-4422(04)00964-0. PMID: 15620855

Clinical prediction guides

Kuroda H, Fujihara K, Mugikura S, Takahashi S, Kushimoto S, Aoki M
J Neurol Sci 2016 Jan 15;360:161-9. Epub 2015 Dec 7 doi: 10.1016/j.jns.2015.12.006. PMID: 26723994
Teunissen CE, Dijkstra C, Polman C
Lancet Neurol 2005 Jan;4(1):32-41. doi: 10.1016/S1474-4422(04)00964-0. PMID: 15620855
Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD
Brain 2002 Oct;125(Pt 10):2332-41. doi: 10.1093/brain/awf226. PMID: 12244089
Huang W, Alexander GE, Chang L, Shetty HU, Krasuski JS, Rapoport SI, Schapiro MB
Neurology 2001 Aug 28;57(4):626-32. doi: 10.1212/wnl.57.4.626. PMID: 11524470
Chang L, Ernst T, Strickland T, Mehringer CM
Am J Psychiatry 1999 May;156(5):716-22. doi: 10.1176/ajp.156.5.716. PMID: 10327904

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