U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced circulating insulin-like growth factor 2 concentration

MedGen UID:
1053061
•Concept ID:
CN377000
•
Finding
HPO: HP:6000404

Definition

The concentration of insulin-like growth factor 2 (IGF2) in the blood circulation is below the lower limit of normal. IGF2 is a peptide hormone regulating various cellular processes such as proliferation and apoptosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating insulin-like growth factor 2 concentration

Professional guidelines

PubMed

Reversible effects of cessation and recommencement of thyroxine treatment on insulin-like growth factors (IGFs) and IGF-binding proteins in patients with total thyroidectomy.
Miell JP, Zini M, Quin JD, Jones J, Portioli I, Valcavi R
J Clin Endocrinol Metab 1994 Nov;79(5):1507-12. doi: 10.1210/jcem.79.5.7525638. PMID: 7525638

Recent clinical studies

Etiology

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis.
Hoeflich A, Fitzner B, Walz C, Hecker M, Tuchscherer A, Brenmoehl J, Zettl UK
Front Endocrinol (Lausanne) 2020;11:565557. Epub 2021 Jan 5 doi: 10.3389/fendo.2020.565557. PMID: 33469444Free PMC Article
Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism.
Caixeta LS, Giesy SL, Krumm CS, Perfield JW 2nd, Butterfield A, Boisclair YR
J Dairy Sci 2019 Dec;102(12):11597-11608. Epub 2019 Sep 20 doi: 10.3168/jds.2019-16696. PMID: 31548064
Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure.
Frystyk J, Ivarsen P, Skjaerbaek C, Flyvbjerg A, Pedersen EB, Orskov H
Kidney Int 1999 Dec;56(6):2076-84. doi: 10.1046/j.1523-1755.1999.00798.x. PMID: 10594783
Free insulin-like growth factors in human obesity.
Frystyk J, Vestbo E, Skjaerbaek C, Mogensen CE, Orskov H
Metabolism 1995 Oct;44(10 Suppl 4):37-44. doi: 10.1016/0026-0495(95)90219-8. PMID: 7476310

Diagnosis

Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats.
Castilla-Cortázar I, García-Fernández M, Delgado G, Puche JE, Sierra I, Barhoum R, González-Barón S
J Transl Med 2011 Jul 6;9:103. doi: 10.1186/1479-5876-9-103. PMID: 21733157Free PMC Article
Low circulating IGF-II concentrations predict weight gain and obesity in humans.
Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ
Diabetes 2003 Jun;52(6):1403-8. doi: 10.2337/diabetes.52.6.1403. PMID: 12765950
Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain.
Armstrong CS, Wuarin L, Ishii DN
J Neurosci Res 2000 Mar 1;59(5):649-60. doi: 10.1002/(SICI)1097-4547(20000301)59:5<649::AID-JNR8>3.0.CO;2-W. PMID: 10686593
Increased pulsatile, but not basal, growth hormone secretion rates and plasma insulin-like growth factor I levels during the periovulatory interval in normal women.
Ovesen P, Vahl N, Fisker S, Veldhuis JD, Christiansen JS, Jørgensen JO
J Clin Endocrinol Metab 1998 May;83(5):1662-7. doi: 10.1210/jcem.83.5.4761. PMID: 9589674
Nutritional regulation of the insulin-like growth factors.
Thissen JP, Ketelslegers JM, Underwood LE
Endocr Rev 1994 Feb;15(1):80-101. doi: 10.1210/edrv-15-1-80. PMID: 8156941

Therapy

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis.
Hoeflich A, Fitzner B, Walz C, Hecker M, Tuchscherer A, Brenmoehl J, Zettl UK
Front Endocrinol (Lausanne) 2020;11:565557. Epub 2021 Jan 5 doi: 10.3389/fendo.2020.565557. PMID: 33469444Free PMC Article
Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody.
Parra-Guillen ZP, Schmid U, Janda A, Freiwald M, Troconiz IF
Clin Pharmacol Ther 2020 Mar;107(3):597-606. Epub 2019 Nov 19 doi: 10.1002/cpt.1648. PMID: 31562819
Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism.
Caixeta LS, Giesy SL, Krumm CS, Perfield JW 2nd, Butterfield A, Boisclair YR
J Dairy Sci 2019 Dec;102(12):11597-11608. Epub 2019 Sep 20 doi: 10.3168/jds.2019-16696. PMID: 31548064
Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk.
Vrieling A, Rookus MA, Kampman E, Bonfrer JM, Korse CM, van Doorn J, Lampe JW, Cats A, Witteman BJ, van Leeuwen FE, van't Veer LJ, Voskuil DW
J Nutr 2007 Feb;137(2):379-83. doi: 10.1093/jn/137.2.379. PMID: 17237315
Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells.
Frost RA, Lang CH
Minerva Endocrinol 2003 Mar;28(1):53-73. PMID: 12621363

Prognosis

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis.
Hoeflich A, Fitzner B, Walz C, Hecker M, Tuchscherer A, Brenmoehl J, Zettl UK
Front Endocrinol (Lausanne) 2020;11:565557. Epub 2021 Jan 5 doi: 10.3389/fendo.2020.565557. PMID: 33469444Free PMC Article
Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody.
Parra-Guillen ZP, Schmid U, Janda A, Freiwald M, Troconiz IF
Clin Pharmacol Ther 2020 Mar;107(3):597-606. Epub 2019 Nov 19 doi: 10.1002/cpt.1648. PMID: 31562819
Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Association of in vitro fertilization outcome with circulating insulin-like growth factor components prior to cycle initiation.
Ramer I, Kanninen TT, Sisti G, Witkin SS, Spandorfer SD
Am J Obstet Gynecol 2015 Sep;213(3):356.e1-6. Epub 2015 Apr 30 doi: 10.1016/j.ajog.2015.04.026. PMID: 25935785
Low circulating IGF-II concentrations predict weight gain and obesity in humans.
Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ
Diabetes 2003 Jun;52(6):1403-8. doi: 10.2337/diabetes.52.6.1403. PMID: 12765950

Clinical prediction guides

Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody.
Parra-Guillen ZP, Schmid U, Janda A, Freiwald M, Troconiz IF
Clin Pharmacol Ther 2020 Mar;107(3):597-606. Epub 2019 Nov 19 doi: 10.1002/cpt.1648. PMID: 31562819
Insulin-like growth factor-1 and soluble FMS-like tyrosine kinase-1 prospectively predict cancelled IVF cycles.
Nasioudis D, Minis E, Irani M, Kreines F, Witkin SS, Spandorfer SD
J Assist Reprod Genet 2019 Dec;36(12):2485-2491. Epub 2019 Nov 21 doi: 10.1007/s10815-019-01618-3. PMID: 31755001Free PMC Article
Association of in vitro fertilization outcome with circulating insulin-like growth factor components prior to cycle initiation.
Ramer I, Kanninen TT, Sisti G, Witkin SS, Spandorfer SD
Am J Obstet Gynecol 2015 Sep;213(3):356.e1-6. Epub 2015 Apr 30 doi: 10.1016/j.ajog.2015.04.026. PMID: 25935785
Acid-labile subunit deficiency: phenotypic similarities and differences between human and mouse.
Domené HM, Bengolea SV, Jasper HG, Boisclair YR
J Endocrinol Invest 2005;28(5 Suppl):43-6. PMID: 16114275
Increased insulin-like growth factor (IGF)-II and IGF/IGF-binding protein ratio in prepubertal constitutionally tall children.
Garrone S, Radetti G, Sidoti M, Bozzola M, Minuto F, Barreca A
J Clin Endocrinol Metab 2002 Dec;87(12):5455-60. doi: 10.1210/jc.2002-020614. PMID: 12466336

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...