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Elevated CSF 5-hydroxyindoleacetic acid concentration

MedGen UID:
1052680
•Concept ID:
CN377971
•
Finding
HPO: HP:6000823

Definition

The concentration of 5-hydroxyindoleacetic acid in the cerebrospinal fluid (CSF) is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated CSF 5-hydroxyindoleacetic acid concentration

Professional guidelines

PubMed

Clinical and biochemical parameters during neuroleptic treatment. I. Investigations with haloperidol.
Rüther E, Schilkrut R, Ackenheil M, Eben E, Hippius H
Pharmakopsychiatr Neuropsychopharmakol 1976 Jan;9(1):33-6. doi: 10.1055/s-0028-1094475. PMID: 981320

Recent clinical studies

Etiology

Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Sullivan GM, Oquendo MA, Huang YY, Mann JJ
Int J Neuropsychopharmacol 2006 Oct;9(5):547-56. Epub 2005 Nov 1 doi: 10.1017/S1461145705006231. PMID: 16259647
5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment.
Stuerenburg HJ, Ganzer S, Müller-Thomsen T
Neuro Endocrinol Lett 2004 Dec;25(6):435-7. PMID: 15665806
Neurochemical differences in the CSF between Binswanger's and Alzheimer's disease.
Strittmatter M, Hamann GF, Grauer MT, Cramer H, Schimrigk K
Dement Geriatr Cogn Disord 1997 Jan-Feb;8(1):34-42. doi: 10.1159/000106598. PMID: 8997550
Elevated cerebrospinal fluid noradrenaline in tardive dyskinesia.
Jeste DV, Doongaji DR, Linnoila M
Br J Psychiatry 1984 Feb;144:177-80. doi: 10.1192/bjp.144.2.177. PMID: 6200172
CSF-changes of HVA and 5-HIAA during intermittent and continuous Parkinson therapy with particular regard to prodipin application.
Oppel F, Schulze G
Pharmakopsychiatr Neuropsychopharmakol 1978 Mar;11(2):76-80. doi: 10.1055/s-0028-1094565. PMID: 347467

Diagnosis

Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.
Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, Hansson O, Björkqvist M, Träskman-Bendz L, Brundin L
Biol Psychiatry 2009 Aug 1;66(3):287-92. Epub 2009 Mar 6 doi: 10.1016/j.biopsych.2009.01.030. PMID: 19268915
Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up.
Manegold C, Hoffmann GF, Degen I, Ikonomidou H, Knust A, Laass MW, Pritsch M, Wilichowski E, Hörster F
J Inherit Metab Dis 2009 Jun;32(3):371-80. Epub 2009 Jan 28 doi: 10.1007/s10545-009-1076-1. PMID: 19172410
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Sullivan GM, Oquendo MA, Huang YY, Mann JJ
Int J Neuropsychopharmacol 2006 Oct;9(5):547-56. Epub 2005 Nov 1 doi: 10.1017/S1461145705006231. PMID: 16259647
Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease.
Abdo WF, De Jong D, Hendriks JC, Horstink MW, Kremer BP, Bloem BR, Verbeek MM
Mov Disord 2004 May;19(5):571-9. doi: 10.1002/mds.10714. PMID: 15133823
Dementias, psychological tests, and neurotransmitters.
Degrell I, Pék G, Nagy D, Nagy E, Hoyer S
Arch Gerontol Geriatr 1985 Dec;4(4):365-71. doi: 10.1016/0167-4943(85)90043-3. PMID: 2421656

Therapy

Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up.
Manegold C, Hoffmann GF, Degen I, Ikonomidou H, Knust A, Laass MW, Pritsch M, Wilichowski E, Hörster F
J Inherit Metab Dis 2009 Jun;32(3):371-80. Epub 2009 Jan 28 doi: 10.1007/s10545-009-1076-1. PMID: 19172410
Plasma concentrations of 5-HT, 5-HIAA, norepinephrine, epinephrine and dopamine in ecstasy users.
Stuerenburg HJ, Petersen K, Bäumer T, Rosenkranz M, Buhmann C, Thomasius R
Neuro Endocrinol Lett 2002 Jun;23(3):259-61. PMID: 12080289
Effects of raclopride treatment on plasma and CSF HVA: relationships with clinical improvement in male schizophrenics.
Csernansky JG, Newcomer JW, Jackson K, Lombrozo L, Faull KF, Zipursky R, Pfefferbaum A, Faustman WO
Psychopharmacology (Berl) 1994 Nov;116(3):291-6. doi: 10.1007/BF02245331. PMID: 7534423
Tetrahydrobiopterin administration in biopterin-deficient progressive dystonia with diurnal variation.
Fink JK, Ravin P, Argoff CE, Levine RA, Brady RO, Hallett M, Barton NW
Neurology 1989 Oct;39(10):1393-5. doi: 10.1212/wnl.39.10.1393. PMID: 2477772
Elevated cerebrospinal fluid noradrenaline in tardive dyskinesia.
Jeste DV, Doongaji DR, Linnoila M
Br J Psychiatry 1984 Feb;144:177-80. doi: 10.1192/bjp.144.2.177. PMID: 6200172

Prognosis

Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up.
Manegold C, Hoffmann GF, Degen I, Ikonomidou H, Knust A, Laass MW, Pritsch M, Wilichowski E, Hörster F
J Inherit Metab Dis 2009 Jun;32(3):371-80. Epub 2009 Jan 28 doi: 10.1007/s10545-009-1076-1. PMID: 19172410
Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression.
Raison CL, Borisov AS, Majer M, Drake DF, Pagnoni G, Woolwine BJ, Vogt GJ, Massung B, Miller AH
Biol Psychiatry 2009 Feb 15;65(4):296-303. Epub 2008 Sep 18 doi: 10.1016/j.biopsych.2008.08.010. PMID: 18801471Free PMC Article
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder.
Sullivan GM, Oquendo MA, Huang YY, Mann JJ
Int J Neuropsychopharmacol 2006 Oct;9(5):547-56. Epub 2005 Nov 1 doi: 10.1017/S1461145705006231. PMID: 16259647
5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment.
Stuerenburg HJ, Ganzer S, Müller-Thomsen T
Neuro Endocrinol Lett 2004 Dec;25(6):435-7. PMID: 15665806
Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease.
Abdo WF, De Jong D, Hendriks JC, Horstink MW, Kremer BP, Bloem BR, Verbeek MM
Mov Disord 2004 May;19(5):571-9. doi: 10.1002/mds.10714. PMID: 15133823

Clinical prediction guides

Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.
Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, Hansson O, Björkqvist M, Träskman-Bendz L, Brundin L
Biol Psychiatry 2009 Aug 1;66(3):287-92. Epub 2009 Mar 6 doi: 10.1016/j.biopsych.2009.01.030. PMID: 19268915
5-Hydroxyindoleacetic acid and homovanillic acid concentrations in cerebrospinal fluid in patients with Alzheimer's disease, depression and mild cognitive impairment.
Stuerenburg HJ, Ganzer S, Müller-Thomsen T
Neuro Endocrinol Lett 2004 Dec;25(6):435-7. PMID: 15665806
Neurochemical differences in the CSF between Binswanger's and Alzheimer's disease.
Strittmatter M, Hamann GF, Grauer MT, Cramer H, Schimrigk K
Dement Geriatr Cogn Disord 1997 Jan-Feb;8(1):34-42. doi: 10.1159/000106598. PMID: 8997550
Elevated CSF dynorphin A [1-8] in Tourette's syndrome.
Leckman JF, Riddle MA, Berrettini WH, Anderson GM, Hardin M, Chappell P, Bissette G, Nemeroff CB, Goodman WK, Cohen DJ
Life Sci 1988;43(24):2015-23. doi: 10.1016/0024-3205(88)90575-9. PMID: 2463450
Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients.
Widerlöv E, Bissette G, Nemeroff CB
J Affect Disord 1988 Mar-Apr;14(2):99-107. doi: 10.1016/0165-0327(88)90051-1. PMID: 2452842

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