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Rest limb pain

MedGen UID:
1052511
Concept ID:
CN377459
Finding
Synonym: Critical limb ischemia
 
HPO: HP:6000627

Definition

Rest pain is a continuous unrelenting pain due to ischemia of the lower leg, beginning with or being aggravated by elevation and being relieved by sitting with legs in a dependent position or by standing. [from HPO]

Professional guidelines

Recent clinical studies

Etiology

Gutiérrez-Espinoza H, Pinto-Concha S, Sepúlveda-Osses O, Araya-Quintanilla F
Ann Phys Rehabil Med 2023 Jun;66(5):101744. Epub 2023 Apr 6 doi: 10.1016/j.rehab.2023.101744. PMID: 37030191
Ortega-Castillo M, Cuesta-Vargas A, Luque-Teba A, Trinidad-Fernández M
Musculoskelet Sci Pract 2022 Dec;62:102645. Epub 2022 Aug 8 doi: 10.1016/j.msksp.2022.102645. PMID: 35964498
Abd El-Azeim AS, Mahmoud AG, Mohamed MT, El-Khateeb YS
Eur J Phys Rehabil Med 2022 Oct;58(5):757-766. Epub 2022 Jun 8 doi: 10.23736/S1973-9087.22.07361-0. PMID: 35673945Free PMC Article
Hoe VC, Urquhart DM, Kelsall HL, Zamri EN, Sim MR
Cochrane Database Syst Rev 2018 Oct 23;10(10):CD008570. doi: 10.1002/14651858.CD008570.pub3. PMID: 30350850Free PMC Article
Patel DS, Roth M, Kapil N
Am Fam Physician 2011 Jan 1;83(1):39-46. PMID: 21888126

Diagnosis

Meunier M
Clin Sports Med 2020 Jul;39(3):657-660. doi: 10.1016/j.csm.2020.03.001. PMID: 32446581
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH, Aboyans V, Aksoy M, Alexandrescu VA, Armstrong D, Azuma N, Belch J, Bergoeing M, Bjorck M, Chakfé N, Cheng S, Dawson J, Debus ES, Dueck A, Duval S, Eckstein HH, Ferraresi R, Gambhir R, Gargiulo M, Geraghty P, Goode S, Gray B, Guo W, Gupta PC, Hinchliffe R, Jetty P, Komori K, Lavery L, Liang W, Lookstein R, Menard M, Misra S, Miyata T, Moneta G, Munoa Prado JA, Munoz A, Paolini JE, Patel M, Pomposelli F, Powell R, Robless P, Rogers L, Schanzer A, Schneider P, Taylor S, De Ceniga MV, Veller M, Vermassen F, Wang J, Wang S; GVG Writing Group for the Joint Guidelines of the Society for Vascular Surgery (SVS), European Society for Vascular Surgery (ESVS), and World Federation of Vascular Societies (WFVS)
Eur J Vasc Endovasc Surg 2019 Jul;58(1S):S1-S109.e33. Epub 2019 Jun 8 doi: 10.1016/j.ejvs.2019.05.006. PMID: 31182334Free PMC Article
Tu P
Am Fam Physician 2018 Jan 15;97(2):86-93. PMID: 29365222
Agyekum EK, Ma K
Chin J Traumatol 2015;18(3):164-9. doi: 10.1016/j.cjtee.2015.03.002. PMID: 26643244
Patel DS, Roth M, Kapil N
Am Fam Physician 2011 Jan 1;83(1):39-46. PMID: 21888126

Therapy

Yamamoto N, Szymski D, Voss A, Ishikawa H, Muraki T, Cunha RA, Ejnisman B, Noack J, McCarty E, Mulcahey MK, Itoi E
J ISAKOS 2023 Oct;8(5):289-295. Epub 2023 Jun 13 doi: 10.1016/j.jisako.2023.06.002. PMID: 37321293
Ortega-Castillo M, Cuesta-Vargas A, Luque-Teba A, Trinidad-Fernández M
Musculoskelet Sci Pract 2022 Dec;62:102645. Epub 2022 Aug 8 doi: 10.1016/j.msksp.2022.102645. PMID: 35964498
Abd El-Azeim AS, Mahmoud AG, Mohamed MT, El-Khateeb YS
Eur J Phys Rehabil Med 2022 Oct;58(5):757-766. Epub 2022 Jun 8 doi: 10.23736/S1973-9087.22.07361-0. PMID: 35673945Free PMC Article
Kashif M, Albalwi A, Alharbi A, Iram H, Manzoor N
J Pak Med Assoc 2021 Dec;71(12):2705-2709. doi: 10.47391/JPMA.1049. PMID: 35150524
Patel DS, Roth M, Kapil N
Am Fam Physician 2011 Jan 1;83(1):39-46. PMID: 21888126

Prognosis

Çağlar Okur S, Aydın A
J Musculoskelet Neuronal Interact 2019 Jun 1;19(2):178-186. PMID: 31186388Free PMC Article
Thompson JR, Henke PK
Adv Surg 2018 Sep;52(1):257-274. Epub 2018 Jun 19 doi: 10.1016/j.yasu.2018.03.012. PMID: 30098617
Elsayed S, Clavijo LC
Cardiol Clin 2015 Feb;33(1):37-47. doi: 10.1016/j.ccl.2014.09.008. PMID: 25439329
Minar E
Hamostaseologie 2009 Jan;29(1):102-9. PMID: 19151858
Silbernagel KG, Thomeé R, Thomeé P, Karlsson J
Scand J Med Sci Sports 2001 Aug;11(4):197-206. doi: 10.1034/j.1600-0838.2001.110402.x. PMID: 11476424

Clinical prediction guides

Wang Q, Jin Q, Cai L, Zhao C, Feng P, Jia J, Xu W, Qian Q, Ding Z, Xu J, Gu C, Zhang S, Shi H, Ma H, Deng Y, Zhang T, Song Y, Wang Q, Zhang Y, Zhou X, Pei L, Yang Y, Liang J, Jiang T, Li H, Liu H, Wu L, Kang P
J Bone Joint Surg Am 2024 Mar 20;106(6):492-500. Epub 2023 Dec 18 doi: 10.2106/JBJS.23.00854. PMID: 38109425
Ortega-Castillo M, Cuesta-Vargas A, Luque-Teba A, Trinidad-Fernández M
Musculoskelet Sci Pract 2022 Dec;62:102645. Epub 2022 Aug 8 doi: 10.1016/j.msksp.2022.102645. PMID: 35964498
Kim DH, Liu J, Beathe JC, Lin Y, Wetmore DS, Kim SJ, Haskins SC, Garvin S, Oxendine JA, Ho MC, Allen AA, Popovic M, Gbaje E, Wu CL, Memtsoudis SG
Anesthesiology 2022 Mar 1;136(3):434-447. doi: 10.1097/ALN.0000000000004111. PMID: 35041742
Romero-Moraleda B, González-García J, Cuéllar-Rayo Á, Balsalobre-Fernández C, Muñoz-García D, Morencos E
J Sports Sci Med 2019 Mar;18(1):172-180. Epub 2019 Feb 11 PMID: 30787665Free PMC Article
Mills JL Sr, Conte MS, Armstrong DG, Pomposelli FB, Schanzer A, Sidawy AN, Andros G; Society for Vascular Surgery Lower Extremity Guidelines Committee
J Vasc Surg 2014 Jan;59(1):220-34.e1-2. Epub 2013 Oct 12 doi: 10.1016/j.jvs.2013.08.003. PMID: 24126108

Recent systematic reviews

Ortega-Castillo M, Cuesta-Vargas A, Luque-Teba A, Trinidad-Fernández M
Musculoskelet Sci Pract 2022 Dec;62:102645. Epub 2022 Aug 8 doi: 10.1016/j.msksp.2022.102645. PMID: 35964498
Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R, Mills JL, Ricco JB, Suresh KR, Murad MH; GVG Writing Group
J Vasc Surg 2019 Jun;69(6S):3S-125S.e40. Epub 2019 May 28 doi: 10.1016/j.jvs.2019.02.016. PMID: 31159978Free PMC Article
Agyekum EK, Ma K
Chin J Traumatol 2015;18(3):164-9. doi: 10.1016/j.cjtee.2015.03.002. PMID: 26643244
Smyth RM, Aflaifel N, Bamigboye AA
Cochrane Database Syst Rev 2015 Oct 19;2015(10):CD001066. doi: 10.1002/14651858.CD001066.pub3. PMID: 26477632Free PMC Article
Kahn SR, Shrier I, Kearon C
Thromb Res 2008;122(6):763-73. Epub 2007 Dec 21 doi: 10.1016/j.thromres.2007.10.011. PMID: 18078981

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