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Reduced CSF creatine concentration

MedGen UID:
1052412
•Concept ID:
CN376996
•
Finding
HPO: HP:6000400

Definition

The concentration of creatine in the cerebrospinal fluid (CSF) is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced CSF creatine concentration

Recent clinical studies

Etiology

HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection.
Cysique LA, Jugé L, Lennon MJ, Gates TM, Jones SP, Lovelace MD, Rae CD, Johnson TP, Nath A, Brew BJ
AIDS 2019 Mar 1;33(3):433-441. doi: 10.1097/QAD.0000000000002076. PMID: 30475266
Decreased left perisylvian GABA concentration in children with autism and unaffected siblings.
Rojas DC, Singel D, Steinmetz S, Hepburn S, Brown MS
Neuroimage 2014 Feb 1;86:28-34. Epub 2013 Jan 28 doi: 10.1016/j.neuroimage.2013.01.045. PMID: 23370056Free PMC Article
Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.
Venkatraman TN, Krishnan RR, Steffens DC, Song AW, Taylor WD
Psychiatry Res 2009 Apr 30;172(1):49-54. doi: 10.1016/j.pscychresns.2008.07.001. PMID: 19179054Free PMC Article
Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.
Chard DT, Griffin CM, McLean MA, Kapeller P, Kapoor R, Thompson AJ, Miller DH
Brain 2002 Oct;125(Pt 10):2342-52. doi: 10.1093/brain/awf240. PMID: 12244090
Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia.
Bustillo JR, Lauriello J, Rowland LM, Jung RE, Petropoulos H, Hart BL, Blanchard J, Keith SJ, Brooks WM
Psychiatry Res 2001 Oct 1;107(3):135-49. doi: 10.1016/s0925-4927(01)00102-0. PMID: 11566430

Diagnosis

The role of gray and white matter segmentation in quantitative proton MR spectroscopic imaging.
Tal A, Kirov II, Grossman RI, Gonen O
NMR Biomed 2012 Dec;25(12):1392-400. Epub 2012 Jun 20 doi: 10.1002/nbm.2812. PMID: 22714729Free PMC Article
Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.
Venkatraman TN, Krishnan RR, Steffens DC, Song AW, Taylor WD
Psychiatry Res 2009 Apr 30;172(1):49-54. doi: 10.1016/j.pscychresns.2008.07.001. PMID: 19179054Free PMC Article
Perioperative changes in cerebral ischemic markers in the cerebrospinal fluid after preoperative nimodipine treatment.
Oehmke MJ, Schirrmeister D, Kuhn DF, Fritz T, Engel J, Hempelmann G
Acta Anaesthesiol Scand 2003 Nov;47(10):1287-91. doi: 10.1046/j.1399-6576.2003.00250.x. PMID: 14616329
Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation.
Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC
Schizophr Res 2001 Oct 1;52(1-2):87-99. doi: 10.1016/s0920-9964(01)00155-4. PMID: 11595395
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
Auer DP, Pütz B, Kraft E, Lipinski B, Schill J, Holsboer F
Biol Psychiatry 2000 Feb 15;47(4):305-13. doi: 10.1016/s0006-3223(99)00159-6. PMID: 10686265

Therapy

Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression.
Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, Fischer J, Chirichigno JW, Ventura J, Elman S, Tsuang J, Walot I, Thomas MA
Neuropsychopharmacology 2007 Dec;32(12):2490-9. Epub 2007 Apr 11 doi: 10.1038/sj.npp.1301387. PMID: 17429412
Perioperative changes in cerebral ischemic markers in the cerebrospinal fluid after preoperative nimodipine treatment.
Oehmke MJ, Schirrmeister D, Kuhn DF, Fritz T, Engel J, Hempelmann G
Acta Anaesthesiol Scand 2003 Nov;47(10):1287-91. doi: 10.1046/j.1399-6576.2003.00250.x. PMID: 14616329
Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia.
Bustillo JR, Lauriello J, Rowland LM, Jung RE, Petropoulos H, Hart BL, Blanchard J, Keith SJ, Brooks WM
Psychiatry Res 2001 Oct 1;107(3):135-49. doi: 10.1016/s0925-4927(01)00102-0. PMID: 11566430
An unusual aminoacidopathy associated with mitochondrial encephalomyopathy.
Perry TL, Hansen S, Booth FA, Penn AM, Jones K, Dilling LA
J Inherit Metab Dis 1989;12(1):23-32. doi: 10.1007/BF01805527. PMID: 2501579

Prognosis

Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.
Chard DT, Griffin CM, McLean MA, Kapeller P, Kapoor R, Thompson AJ, Miller DH
Brain 2002 Oct;125(Pt 10):2342-52. doi: 10.1093/brain/awf240. PMID: 12244090

Clinical prediction guides

HIV brain latency as measured by CSF BcL11b relates to disrupted brain cellular energy in virally suppressed HIV infection.
Cysique LA, Jugé L, Lennon MJ, Gates TM, Jones SP, Lovelace MD, Rae CD, Johnson TP, Nath A, Brew BJ
AIDS 2019 Mar 1;33(3):433-441. doi: 10.1097/QAD.0000000000002076. PMID: 30475266
Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression.
Venkatraman TN, Krishnan RR, Steffens DC, Song AW, Taylor WD
Psychiatry Res 2009 Apr 30;172(1):49-54. doi: 10.1016/j.pscychresns.2008.07.001. PMID: 19179054Free PMC Article
Perioperative changes in cerebral ischemic markers in the cerebrospinal fluid after preoperative nimodipine treatment.
Oehmke MJ, Schirrmeister D, Kuhn DF, Fritz T, Engel J, Hempelmann G
Acta Anaesthesiol Scand 2003 Nov;47(10):1287-91. doi: 10.1046/j.1399-6576.2003.00250.x. PMID: 14616329
Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis.
Chard DT, Griffin CM, McLean MA, Kapeller P, Kapoor R, Thompson AJ, Miller DH
Brain 2002 Oct;125(Pt 10):2342-52. doi: 10.1093/brain/awf240. PMID: 12244090
Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation.
Auer DP, Wilke M, Grabner A, Heidenreich JO, Bronisch T, Wetter TC
Schizophr Res 2001 Oct 1;52(1-2):87-99. doi: 10.1016/s0920-9964(01)00155-4. PMID: 11595395

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