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Mucoepidermoid neoplasm (morphology)

MedGen UID:
104922
Concept ID:
C0206712
Neoplastic Process
Synonyms: Mucoepidermoid Tumor; Mucoepidermoid Tumors; Tumor, Mucoepidermoid; Tumors, Mucoepidermoid
SNOMED CT: Mucoepidermoid neoplasm (127571003); Mucoepidermoid neoplasm (morphology) (127571003)

Definition

A malignant epithelial tumor of glandular tissue, especially the salivary glands, characterized by acini with mucus-producing cells and by the presence of malignant squamous elements. Most mucoepidermoid tumors are low-grade lesions readily cured by adequate excision. They may appear in any age group. They grow slowly. If high-grade, they behave aggressively, widely infiltrating the salivary gland and producing lymph node and distant metastases. (Dorland, 27th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucoepidermoid neoplasm (morphology)

Professional guidelines

PubMed

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Lewis AG, Tong T, Maghami E
Otolaryngol Clin North Am 2016 Apr;49(2):343-80. doi: 10.1016/j.otc.2015.11.001. PMID: 27040585

Recent clinical studies

Etiology

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Merna C, Kita A, Wester J, Diaz-Aguilar D, Goldstein JD, Palma Diaz F, Blackwell K, St John MA
Laryngoscope 2018 May;128(5):1083-1092. Epub 2017 Aug 22 doi: 10.1002/lary.26832. PMID: 28833169
Yin LX, Ha PK
Cancer 2016 Jun 15;122(12):1822-31. Epub 2016 Feb 29 doi: 10.1002/cncr.29890. PMID: 26928905Free PMC Article

Diagnosis

Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Kalhor N, Moran CA
Expert Rev Respir Med 2018 Mar;12(3):249-255. Epub 2018 Jan 17 doi: 10.1080/17476348.2018.1428563. PMID: 29338644
Varela P, Pio L, Torre M
Semin Pediatr Surg 2016 Jun;25(3):150-5. Epub 2016 Feb 23 doi: 10.1053/j.sempedsurg.2016.02.013. PMID: 27301601

Therapy

Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
Lam AK
Methods Mol Biol 2018;1756:67-76. doi: 10.1007/978-1-4939-7734-5_6. PMID: 29600360
Varan A, Akyüz C, Ataş E, Yücel T, Aydın B, Yalçın B, Kutluk T, Büyükpamukçu M
Pediatr Hematol Oncol 2014 Nov;31(8):681-6. Epub 2014 Sep 23 doi: 10.3109/08880018.2014.942936. PMID: 25247345
Haerle SK, Gullane PJ, Witterick IJ, Zweifel C, Gentili F
Neurosurg Clin N Am 2013 Jan;24(1):39-49. Epub 2012 Sep 10 doi: 10.1016/j.nec.2012.08.004. PMID: 23174356
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Dalgic A, Karakoc O, Aydin U, Hidir Y, Gamsizkan M, Karahatay S, Gerek M
J Craniofac Surg 2014 May;25(3):e289-91. doi: 10.1097/SCS.0000000000000723. PMID: 24777018
Luna MA
Adv Anat Pathol 2006 Nov;13(6):293-307. doi: 10.1097/01.pap.0000213058.74509.d3. PMID: 17075295

Clinical prediction guides

Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Ma C, Yang C, Peng A, Sun T, Ji X, Mi J, Wei L, Shen S, Feng Q
Mol Cancer 2023 Oct 13;22(1):170. doi: 10.1186/s12943-023-01876-x. PMID: 37833788Free PMC Article
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Sivakumar N, Narwal A, Pandiar D, Devi A, Anand R, Bansal D, Kamboj M
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):189-198. Epub 2021 Jul 21 doi: 10.1016/j.oooo.2021.07.010. PMID: 34518135
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Hamza A, Younes AI, Kalhor N
Adv Anat Pathol 2019 Nov;26(6):341-345. doi: 10.1097/PAP.0000000000000250. PMID: 31593977

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