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Ossification of posterior longitudinal ligament

MedGen UID:
104849
•Concept ID:
C0206366
•
Pathologic Function
Synonyms: Calcification of Posterior Longitudinal Ligament; Ossification of Posterior Longitudinal Ligament; Posterior Longitudinal Ligament Calcification; Posterior Longitudinal Ligament Ossification
SNOMED CT: Ossification of the posterior longitudinal ligament (90448008); Posterior longitudinal ligament calcification (90448008); Ossification of posterior longitudinal ligament (90448008)

Definition

A disorder characterized by benign depositions of calcium in the posterior longitudinal ligament. Signs and symptoms result from the compression of nerve roots and include motor and sensory disturbances in the lower and upper extremities, and pain in the neck and arms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOssification of posterior longitudinal ligament

Professional guidelines

PubMed

Outcome of Thoracic Column Antedisplacement and Fusion in Treatment of Thoracic Myelopathy Caused by Ossification of Posterior Longitudinal Ligament: A Case Series Study.
Ma X, Wang B, Chen Y, Ge S, Zou X, Zhang S, Xia H
Oper Neurosurg (Hagerstown) 2021 Aug 16;21(3):118-125. doi: 10.1093/ons/opab193. PMID: 34097732
Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020.
Sun XF, Wang Y, Sun JC, Xu XM, Kong QJ, Chen Y, Yang HS, Liu Y, Guo YF, Shi GD, Chen XS, Chen DY, Shen Y, Hao DJ, Shen HX, Zhu QS, Yuan W, Jia LS, Shi JG
J Orthop Surg (Hong Kong) 2020 Sep-Dec;28(3):2309499020975213. doi: 10.1177/2309499020975213. PMID: 33355038
Multicenter cross-sectional study of the clinical features and types of treatment of spinal cord-related pain syndrome.
Nakajima H, Uchida K, Taguchi T, Yamashita T, Tominaga T, Tanaka M, Yamagata M, Kaito T, Ushida T
J Orthop Sci 2019 Sep;24(5):798-804. Epub 2019 Feb 15 doi: 10.1016/j.jos.2019.01.012. PMID: 30777363

Recent clinical studies

Etiology

Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments.
Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
High whole-body bone mineral density in ossification of the posterior longitudinal ligament.
Fujita R, Endo T, Takahata M, Koike Y, Yoneoka D, Suzuki R, Tanaka M, Yamada K, Sudo H, Hasegawa T, Terkawi MA, Kadoya K, Iwasaki N
Spine J 2023 Oct;23(10):1461-1470. Epub 2023 Jul 10 doi: 10.1016/j.spinee.2023.06.400. PMID: 37437695
Dyslipidemia as a novel risk for the development of symptomatic ossification of the posterior longitudinal ligament.
Fukada S, Endo T, Takahata M, Kanayama M, Koike Y, Fujita R, Suzuki R, Murakami T, Hasegawa T, Terkawi MA, Hashimoto T, Yamada K, Sudo H, Kadoya K, Iwasaki N
Spine J 2023 Sep;23(9):1287-1295. Epub 2023 May 7 doi: 10.1016/j.spinee.2023.05.005. PMID: 37160167
Progression of Spinal Ligament Ossification in Patients with Thoracic Myelopathy.
Zhai J, Guo S, Li J, Chen B, Zhao Y
Orthop Surg 2022 Sep;14(9):1958-1963. Epub 2022 Jul 15 doi: 10.1111/os.13291. PMID: 35837729Free PMC Article
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012

Diagnosis

Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments.
Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020.
Sun XF, Wang Y, Sun JC, Xu XM, Kong QJ, Chen Y, Yang HS, Liu Y, Guo YF, Shi GD, Chen XS, Chen DY, Shen Y, Hao DJ, Shen HX, Zhu QS, Yuan W, Jia LS, Shi JG
J Orthop Surg (Hong Kong) 2020 Sep-Dec;28(3):2309499020975213. doi: 10.1177/2309499020975213. PMID: 33355038
Ossification of the posterior longitudinal ligament in the cervical spine: a review.
Boody BS, Lendner M, Vaccaro AR
Int Orthop 2019 Apr;43(4):797-805. Epub 2018 Aug 16 doi: 10.1007/s00264-018-4106-5. PMID: 30116867
Diagnosis and surgical management of cervical ossification of the posterior longitudinal ligament.
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269

Therapy

Reoperation rate and risk factors of reoperation for ossification of the posterior longitudinal ligament (OPLL): a systematic review and meta-analysis.
Tayal A, Pahwa B, Garg K
Neurosurg Rev 2023 Nov 24;46(1):313. doi: 10.1007/s10143-023-02215-w. PMID: 37996772
Comparison of the outcome after anterior cervical ossified posterior longitudinal ligament en bloc resection versus posterior total laminectomy and fusion in patients with ossification of the cervical posterior longitudinal ligament: a prospective randomized controlled trial.
Cao B, Chen J, Yuan B, Sun Y, Zhou S, Zhao Y, Xu Z, Tang Y, Chen X
Bone Joint J 2023 Mar 15;105-B(4):412-421. doi: 10.1302/0301-620X.105B4.BJJ-2022-0804.R2. PMID: 36924177
Surgical interventions for cervical spondylosis due to ossification of posterior longitudinal ligament: A meta-analysis.
Wu D, Liu CZ, Yang H, Li H, Chen N
Medicine (Baltimore) 2017 Aug;96(33):e7590. doi: 10.1097/MD.0000000000007590. PMID: 28816942Free PMC Article
Conservative management of ossification of the posterior longitudinal ligament. A review.
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818
Cervical laminoplasty.
Steinmetz MP, Resnick DK
Spine J 2006 Nov-Dec;6(6 Suppl):274S-281S. doi: 10.1016/j.spinee.2006.04.023. PMID: 17097547

Prognosis

Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments.
Kato H, Braddock DT, Ito N
Curr Osteoporos Rep 2023 Oct;21(5):552-566. Epub 2023 Aug 2 doi: 10.1007/s11914-023-00814-6. PMID: 37530996Free PMC Article
Intraoperative evoked potentials in patients with ossification of posterior longitudinal ligament.
Yoo M, Park YG, Cho YE, Lim CH, Chung SY, Kim D, Park J
J Clin Monit Comput 2022 Feb;36(1):247-258. Epub 2021 Feb 6 doi: 10.1007/s10877-020-00646-0. PMID: 33548015
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Role of Runx2 polymorphisms in risk and prognosis of ossification of posterior longitudinal ligament.
Chang F, Li L, Gao G, Ding S, Yang J, Zhang T, Zuo G
J Clin Lab Anal 2017 Jul;31(4) Epub 2016 Oct 5 doi: 10.1002/jcla.22068. PMID: 27704615Free PMC Article
Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history.
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284

Clinical prediction guides

Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.
Le HV, Wick JB, Van BW, Klineberg EO
J Am Acad Orthop Surg 2022 Sep 1;30(17):820-830. Epub 2022 May 18 doi: 10.5435/JAAOS-D-22-00049. PMID: 35587949
Ossification of posterior longitudinal ligament and fluorosis.
Reddy KVS, Mudumba VS, Tokala IM, Reddy DR
Neurol India 2018 Sep-Oct;66(5):1394-1399. doi: 10.4103/0028-3886.241343. PMID: 30233012
Ossification of the posterior longitudinal ligament of the cervical spine: etiology and natural history.
Matsunaga S, Sakou T
Spine (Phila Pa 1976) 2012 Mar 1;37(5):E309-14. doi: 10.1097/BRS.0b013e318241ad33. PMID: 22146284
Conservative management of ossification of the posterior longitudinal ligament. A review.
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818
Ossification of the posterior longitudinal ligament: pathogenesis, management, and current surgical approaches. A review.
Smith ZA, Buchanan CC, Raphael D, Khoo LT
Neurosurg Focus 2011 Mar;30(3):E10. doi: 10.3171/2011.1.FOCUS10256. PMID: 21361748

Recent systematic reviews

Reoperation rate and risk factors of reoperation for ossification of the posterior longitudinal ligament (OPLL): a systematic review and meta-analysis.
Tayal A, Pahwa B, Garg K
Neurosurg Rev 2023 Nov 24;46(1):313. doi: 10.1007/s10143-023-02215-w. PMID: 37996772
Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review.
Byvaltsev VA, Kalinin AA, Hernandez PA, Shepelev VV, Pestryakov YY, Aliyev MA, Giers MB
Int J Mol Sci 2022 Nov 3;23(21) doi: 10.3390/ijms232113479. PMID: 36362274Free PMC Article
Comparison of Interventions for Cervical Ossification of Posterior Longitudinal Ligament: A Systematic Review and Network Meta-Analysis.
Wang H, Yang R, Liu H, Meng Y, Hong Y
World Neurosurg 2021 Nov;155:1-12. Epub 2021 Aug 5 doi: 10.1016/j.wneu.2021.07.138. PMID: 34365049
Comparison of laminoplasty versus laminectomy and fusion in the treatment of multilevel cervical ossification of the posterior longitudinal ligament: A systematic review and meta-analysis.
Ma L, Liu FY, Huo LS, Zhao ZQ, Sun XZ, Li F, Ding WY
Medicine (Baltimore) 2018 Jul;97(29):e11542. doi: 10.1097/MD.0000000000011542. PMID: 30024545Free PMC Article
Conservative management of ossification of the posterior longitudinal ligament. A review.
Pham MH, Attenello FJ, Lucas J, He S, Stapleton CJ, Hsieh PC
Neurosurg Focus 2011 Mar;30(3):E2. doi: 10.3171/2011.1.FOCUS10273. PMID: 21434818

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