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Soft Tissue Sarcoma Tumor Analysis, Fusion Detection by RT-PCR
Clinical Genetic Test
Help
offered by
Institute for Genomic Medicine (IGM) Clinical Laboratory
View lab's test page
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GTR Test Accession: Help GTR000597231.1
CAP
CANCER
Registered in GTR: 2021-12-14
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Last annual review date for the lab: 2024-06-14 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Therapeutic management
Conditions (1): Help
Soft tissue sarcoma
Genes (12): Help
ERG (21q22.2); ETV6 (12p13.2); EWSR1 (22q12.2); FLI1 (11q24.3); FOXO1 (13q14.11) more...
Methods (1): Help
Molecular Genetics - RNA analysis: RT-PCR
Target population: Help
Individuals diagnosed with sarcoma or suspected sarcoma
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Institute for Genomic Medicine (IGM) Clinical Laboratory
View lab's website
View lab's test page
Test short name: Help
Sarcoma RT-PCR
Specimen Source: Help
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Physician
  • Nurse Practitioner
Test Order Code: Help
RTPCR
View other test codes
CPT codes: Help
**AMA CPT codes notice

Copyright: 2023 American Medical Association. All rights reserved.

Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Samples can be accepted 7 days a week (Monday - Sunday). All samples must be labeled with minimum of two patient identifying information (e.g., Patient Name and Date of Birth). Please Submit disease-involved sample with a completed requisition form and a pathology report documenting the diagnosis.
Order URL
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
No
Pre-test genetic counseling required: Help
No
Post-test genetic counseling required: Help
No
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 12
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument *
RNA analysis
RT-PCR
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Therapeutic management
Target population: Help
Individuals diagnosed with sarcoma or suspected sarcoma
Variant Interpretation:
Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
No.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Yes. No systemic re-evaluation of previously reported findings are currently performed.
Recommended fields not provided:
Clinical validity, Clinical utility, What is the protocol for interpreting a variation as a VUS?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
This assay will detect >99% of following gene fusions if specimen meets specimen requirement for volume, quality, and sufficient tumor content: EWSR1-FLI1, EWSR1-ERG, PAX3-FOXO1, PAX7-FOXO1, SYT-SSX1, SYT-SSX2, EWSR1-WT1, ETV6-NTRK3
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
College of American Pathologists, CAP
VUS:
Laboratory's policy on reporting novel variations Help
Unusual or clinically significant novel variants will be communicated to the ordering provider via telephone call or email communication.
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: Not Applicable
Additional Information

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.