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PML/RARA t(15;17) Translocation assay
Clinical Genetic Test
Help
offered by
Cincinnati Children's Hospital Medical Center Genetics and Genomics Diagnostic Laboratory
GTR Test Accession: Help GTR000593765.1
IMMUNOLOGYINHERITED DISEASECANCER ... View more
Last updated in GTR: 2021-08-12
View version history
Last annual review date for the lab: 2023-07-31 LinkOut
At a Glance
Test purpose: Help
Diagnosis
Conditions (1): Help
Acute promyelocytic leukemia
Chromosomal regions/ Mitochondria (1): Help
t(15;17)
Methods (1): Help
Molecular Genetics - RNA analysis: RT-PCR
Target population: Help
Not provided
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Cincinnati Children's Hospital Medical Center Genetics and Genomics Diagnostic Laboratory
View lab's website
Test short name: Help
PML/RARA t(15;17)
Who can order: Help
  • Health Care Provider
Lab contact: Help
Lab Administration, Administrator
LabGeneticCounselors@cchmc.org
513-636-4474
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
Complete the appropriate test requisition and have it signed by the referring physician.
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Informed consent required: Help
Decline to answer
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Test Order Code, Specimen source, Test strategy, Test development
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Chromosomal regions/Mitochondria Help
Total chromosomal regions/mitochondria: 1
Chromosomal region/Mitochondrion Associated condition
Methodology
Total methods: 1
Method Category Help
Test method Help
Instrument *
RNA analysis
RT-PCR
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis
Recommended fields not provided:
Clinical validity, Clinical utility, Target population, What is the protocol for interpreting a variation as a VUS?, Are family members with defined clinical status recruited to assess significance of VUS without charge?, Will the lab re-contact the ordering physician if variant interpretation changes?, Is research allowed on the sample after clinical testing is complete?, Sample negative report, Sample positive report
Technical Information
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
The assay is able to detect ~5 and 10 copies of PML/ RARA BCR1 fusion within a pool of normal cells with a sensitivity of 90% and 100%, respectively. The assay is able to detect 5 and 10 copies of PML/RARA BCR3 fusion within a pool of normal cells with … View more
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
Yes

Method used for proficiency testing: Help
Inter-Laboratory
Recommended fields not provided:
Test Confirmation, Assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information

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