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STRC Panel
Clinical Genetic Test
Help
offered by
Molecular Vision Laboratory
View lab's test page
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GTR Test Accession: Help GTR000560988.5
Last updated in GTR: 2023-02-14
View version history
Last annual review date for the lab: 2024-01-22 LinkOut
At a Glance
Test purpose: Help
Diagnosis; Mutation Confirmation; Pre-symptomatic; ...
Conditions (1): Help
Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive
Genes (1): Help
STRC (15q15.3)
Methods (2): Help
Molecular Genetics - Deletion/duplication analysis: Quantitative PCR (qPCR); ...
Target population: Help
Not provided
Clinical validity: Help
Not provided
Clinical utility: Help
Not provided
Ordering Information
Offered by: Help
Molecular Vision Laboratory
View lab's website
View lab's test page
Specimen Source: Help
  • Amniocytes
  • Amniotic fluid
  • Bone marrow
  • Buccal swab
  • Buffy coat
  • Cell culture
  • Chorionic villi
  • Cord blood
  • Dried blood spot (DBS) card
  • Fetal blood
  • Fibroblasts
  • Fresh tissue
  • Frozen tissue
  • Isolated DNA
  • Peripheral (whole) blood
  • Saliva
  • White blood cell prep
  • View specimen requirements
Who can order: Help
  • Genetic Counselor
  • Health Care Provider
  • Licensed Physician
Test Order Code: Help
STRC
View other test codes
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
After obtaining the patient specimen and patient information, please ship us the specimen and accompanying information to 1920 NE Stucki Ave, Suite 150, Hillsboro, OR 97006

The patient information and test details can be provided one of two ways:
1. Via our online submission platform (https://www.molecularvisionlab.com/of/samplesub/#login) - once …
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Order URL
Test development: Help
Test developed by laboratory (no manufacturer test name)
Informed consent required: Help
Yes
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Lab contact for this test, Test strategy
Conditions Help
Total conditions: 1
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 1
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Methodology
Total methods: 2
Method Category Help
Test method Help
Instrument *
Deletion/duplication analysis
Quantitative PCR (qPCR)
Sequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Mutation Confirmation; Pre-symptomatic; Predictive; Risk Assessment; Screening; Therapeutic management
Variant Interpretation:
What is the protocol for interpreting a variation as a VUS? Help
VUS is called when the identified variation is: (1) novel (not in any database); (2) rare (allele frequency <0.005) with no additional information available or called VUS by published references and/or ClinVar; (3) rare (allele frequency <0.005) and called as a mutation by only one published reference

Are family members with defined clinical status recruited to assess significance of VUS without charge? Help
Yes.

Will the lab re-contact the ordering physician if variant interpretation changes? Help
Yes. We either call or email by using the information provided to us in the requisition forms.
Sample reports:
Sample Negative Report Help
Sample Negative Report

Sample Positive Report Help
Sample Positive Report

Sample VUS Report Help
Sample VUS Report
Recommended fields not provided:
Clinical validity, Clinical utility, Target population, Is research allowed on the sample after clinical testing is complete?
Technical Information
Test Procedure: Help
NGS of entire STRC gene, TaqMan qPCR for deletion/duplication analysis
Test Confirmation: Help
Independent repeat testing
Availability: Help
Tests performed
Entire test performed in-house
Analytical Validity: Help
Ongoing clinical validation. Sensitivity and accuracy in mutation calling for 8 positive control samples was 100%.
Proficiency testing (PT):
Is proficiency testing performed for this test? Help
No
VUS:
Software used to interpret novel variations Help
ExAC, dbSNP, ClinVar, MVL database

Laboratory's policy on reporting novel variations Help
We report novel variants unless clients specifically state that they don't want us to include novel variants in reports.
Recommended fields not provided:
Assay limitations, Description of internal test validation method, Citations for Analytical validity, PT Provider, Description of PT method, Major CAP category, CAP category, CAP test list
Regulatory Approval
FDA Review: Help
Category: FDA exercises enforcement discretion
Additional Information
Consumer resources:

IMPORTANT NOTE: NIH does not independently verify information submitted to GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.