MYC MYC proto-oncogene, bHLH transcription factor
Gene ID: 4609, updated on 31-Jul-2024Gene type: protein coding
Also known as: MRTL; MYCC; c-Myc; bHLHe39
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- Go to complete Gene record for MYC
- Go to Variation Viewer for MYC variants
Summary
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
A common variant at 8q24.21 is associated with renal cell cancer. GeneReviews: Not available | |
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. GeneReviews: Not available | |
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. GeneReviews: Not available | |
A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer. GeneReviews: Not available | |
Burkitt lymphoma | See labs |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. GeneReviews: Not available | |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies. GeneReviews: Not available | |
Genome-wide association scan for variants associated with early-onset prostate cancer. GeneReviews: Not available | |
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. GeneReviews: Not available | |
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. GeneReviews: Not available | |
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. GeneReviews: Not available | |
Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer. GeneReviews: Not available | |
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. GeneReviews: Not available | |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. GeneReviews: Not available | |
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. GeneReviews: Not available | |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. GeneReviews: Not available | |
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. GeneReviews: Not available | |
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. GeneReviews: Not available | |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer. GeneReviews: Not available |
Genomic context
- Location:
- 8q24.21
- Sequence:
- Chromosome: 8; NC_000008.11 (127735434..127742951)
- Total number of exons:
- 3
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | Variation Viewer for MYC variants |
Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- MYC database
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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